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December 2012 Volume 28 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Cellular prion protein accelerates colorectal cancer metastasis via the Fyn-SP1-SATB1 axis

  • Authors:
    • Qianwei Wang
    • Jianming Qian
    • Fangrui Wang
    • Zhenyu Ma
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Huashan Hospital, Fudan University, Shanghai 200032, P.R. China
  • Pages: 2029-2034
    |
    Published online on: September 12, 2012
       https://doi.org/10.3892/or.2012.2025
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Abstract

The cellular prion protein (PrPc) is a glycoprotein anchored by glycosylphosphatidylinositol to the cell surface and is abundantly expressed in various tissues. The putative roles of PrPc are thought to be related to cell signaling, survival, and differentiation and cancer progression. In this study, we demonstrated that the expression of PrPc correlates with a more aggressive and histologically unfavorable disease in colorectal carcinomas. Moreover, we found that PrPc mediates the process of epithelial-mesenchymal transition and, thereby, promotes CRC metastasis. Transcriptome profiling of PrPc-depleted cells revealed downregulation of the special AT-rich sequence-binding protein-1 (SATB1). PrPc is demonstrated to be involved in regulating SATB1 expression via the Fyn-SP1 pathway. Since SATB1 has been previously proposed as a key protein that controls tumor development and progression, knockdown of PrPc resulted in a reduced metastatic capacity in CRC cells, as well as a reduction in distant metastases in vivo. In conclusion, our data characterize a novel molecular mechanism that links PrPc expression to the regulation of CRC metastasis. Targeting PrPc will, therefore, be a promising strategy to overcome the metastatic advantage in colorectal tumors.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Q, Qian J, Wang F and Ma Z: Cellular prion protein accelerates colorectal cancer metastasis via the Fyn-SP1-SATB1 axis. Oncol Rep 28: 2029-2034, 2012.
APA
Wang, Q., Qian, J., Wang, F., & Ma, Z. (2012). Cellular prion protein accelerates colorectal cancer metastasis via the Fyn-SP1-SATB1 axis. Oncology Reports, 28, 2029-2034. https://doi.org/10.3892/or.2012.2025
MLA
Wang, Q., Qian, J., Wang, F., Ma, Z."Cellular prion protein accelerates colorectal cancer metastasis via the Fyn-SP1-SATB1 axis". Oncology Reports 28.6 (2012): 2029-2034.
Chicago
Wang, Q., Qian, J., Wang, F., Ma, Z."Cellular prion protein accelerates colorectal cancer metastasis via the Fyn-SP1-SATB1 axis". Oncology Reports 28, no. 6 (2012): 2029-2034. https://doi.org/10.3892/or.2012.2025
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Q, Qian J, Wang F and Ma Z: Cellular prion protein accelerates colorectal cancer metastasis via the Fyn-SP1-SATB1 axis. Oncol Rep 28: 2029-2034, 2012.
APA
Wang, Q., Qian, J., Wang, F., & Ma, Z. (2012). Cellular prion protein accelerates colorectal cancer metastasis via the Fyn-SP1-SATB1 axis. Oncology Reports, 28, 2029-2034. https://doi.org/10.3892/or.2012.2025
MLA
Wang, Q., Qian, J., Wang, F., Ma, Z."Cellular prion protein accelerates colorectal cancer metastasis via the Fyn-SP1-SATB1 axis". Oncology Reports 28.6 (2012): 2029-2034.
Chicago
Wang, Q., Qian, J., Wang, F., Ma, Z."Cellular prion protein accelerates colorectal cancer metastasis via the Fyn-SP1-SATB1 axis". Oncology Reports 28, no. 6 (2012): 2029-2034. https://doi.org/10.3892/or.2012.2025
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