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Article

Identification of novel splicing variants from RON proto-oncogene pre-mRNA

  • Authors:
    • Heegyum Moon
    • Sunghee Cho
    • Xiaoming Yang
    • Jianhua Zhou
    • Tiing Jen Loh
    • Xuexiu Zheng
    • Haihong Shen
  • View Affiliations / Copyright

    Affiliations: School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500-712, Republic of Korea, JiangSu Key Laboratory of Neuroregeneration, Nantong University, Nantong, P.R. China
  • Pages: 2217-2220
    |
    Published online on: September 18, 2012
       https://doi.org/10.3892/or.2012.2043
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Abstract

RON is a proto-oncogene that induces cell dissociation, migration and matrix invasion. RON∆160, a splicing variant of RON, is a natural splicing product in colon cancers that is produced through skipping of exons 5 and 6 in alternative splicing process. RON∆160 promotes cellular transformation in vitro and tumor formation in vivo. We present, here, two novel splicing variants of RON in the partial splicing events that involve exons 5 and 6. The common facts of these two novel splicing variants are that exons 4-7 are included. In addition, intron 4 is spliced whereas intron 5 is included in both variants. The difference of these two isoforms is the inclusion or skipping of intron 6. In one variant intron 6 is included, but intron 6 is skipped in another variant. These two variants should be truncated but these proteins have not yet been detected.
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Copy and paste a formatted citation
Spandidos Publications style
Moon H, Cho S, Yang X, Zhou J, Loh TJ, Zheng X and Shen H: Identification of novel splicing variants from RON proto-oncogene pre-mRNA. Oncol Rep 28: 2217-2220, 2012.
APA
Moon, H., Cho, S., Yang, X., Zhou, J., Loh, T.J., Zheng, X., & Shen, H. (2012). Identification of novel splicing variants from RON proto-oncogene pre-mRNA. Oncology Reports, 28, 2217-2220. https://doi.org/10.3892/or.2012.2043
MLA
Moon, H., Cho, S., Yang, X., Zhou, J., Loh, T. J., Zheng, X., Shen, H."Identification of novel splicing variants from RON proto-oncogene pre-mRNA". Oncology Reports 28.6 (2012): 2217-2220.
Chicago
Moon, H., Cho, S., Yang, X., Zhou, J., Loh, T. J., Zheng, X., Shen, H."Identification of novel splicing variants from RON proto-oncogene pre-mRNA". Oncology Reports 28, no. 6 (2012): 2217-2220. https://doi.org/10.3892/or.2012.2043
Copy and paste a formatted citation
x
Spandidos Publications style
Moon H, Cho S, Yang X, Zhou J, Loh TJ, Zheng X and Shen H: Identification of novel splicing variants from RON proto-oncogene pre-mRNA. Oncol Rep 28: 2217-2220, 2012.
APA
Moon, H., Cho, S., Yang, X., Zhou, J., Loh, T.J., Zheng, X., & Shen, H. (2012). Identification of novel splicing variants from RON proto-oncogene pre-mRNA. Oncology Reports, 28, 2217-2220. https://doi.org/10.3892/or.2012.2043
MLA
Moon, H., Cho, S., Yang, X., Zhou, J., Loh, T. J., Zheng, X., Shen, H."Identification of novel splicing variants from RON proto-oncogene pre-mRNA". Oncology Reports 28.6 (2012): 2217-2220.
Chicago
Moon, H., Cho, S., Yang, X., Zhou, J., Loh, T. J., Zheng, X., Shen, H."Identification of novel splicing variants from RON proto-oncogene pre-mRNA". Oncology Reports 28, no. 6 (2012): 2217-2220. https://doi.org/10.3892/or.2012.2043
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