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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2013 Volume 29 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

WAP four-disulfide core domain protein 2 mediates the proliferation of human ovarian cancer cells through the regulation of growth- and apoptosis-associated genes

  • Authors:
    • Yao Chen
    • Xia Mu
    • Suihai Wang
    • Liang Zhao
    • Yingsong Wu
    • Jiliang Li
    • Ming Li

  • View Affiliations / Copyright

    Affiliations: School of Biotechnology, Southern Medical University, Guangzhou 510515, P.R. China, Guizhou Provincial People's Hospital, Guiyang, Guizhou 550002, P.R. China, Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, P.R. China, Cancer Research UK (CRUK) Molecular Oncology Laboratories, Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK
  • Pages: 288-296
    |
    Published online on: October 31, 2012
       https://doi.org/10.3892/or.2012.2114
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Abstract

The WAP four-disulfide core domain protein 2 (WFDC2) is frequently overexpressed in epithelial ovarian cancer cells and has been proposed as a potential biomarker. The biological function of WFDC2 in tumor progression remains unclear. In this study, the stable expression of short hairpin RNA (shRNA) against WFDC2 in the human ovarian SKOV3 cell line was established. Cell proliferation in vitro was determined by MTT assay. Cell cycle and apoptosis were analyzed by FACS. The expression of genes related to cell proliferation and survival was detected by real-time RT-PCR and western blotting. In vivo tumor growth assay was performed by establishing WFDC2-knockdown xenografts in nude mice and monitoring tumor growth. The expression of WFDC2, Ki67 and activated caspase-3 was analyzed by immunohistochemistry in order to determine the role of WFDC2 in proliferation and apoptosis. Our results revealed that the silencing of WFDC2 abolished ovarian cancer cell proliferation, suppressing tumor formation and growth in ovarian cancer cells both in vitro and in vivo. The knockdown of WFDC2 induced upregulation of Fasl and the downregulation of cyclin D1 activated caspase-3 and Ki67. These results indicate that WFDC2 plays a crucial role in tumor formation and growth in ovarian cancer cells. WFDC2 may be a potential therapeutic target for epithelial ovarian cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Chen Y, Mu X, Wang S, Zhao L, Wu Y, Li J and Li M: WAP four-disulfide core domain protein 2 mediates the proliferation of human ovarian cancer cells through the regulation of growth- and apoptosis-associated genes. Oncol Rep 29: 288-296, 2013.
APA
Chen, Y., Mu, X., Wang, S., Zhao, L., Wu, Y., Li, J., & Li, M. (2013). WAP four-disulfide core domain protein 2 mediates the proliferation of human ovarian cancer cells through the regulation of growth- and apoptosis-associated genes. Oncology Reports, 29, 288-296. https://doi.org/10.3892/or.2012.2114
MLA
Chen, Y., Mu, X., Wang, S., Zhao, L., Wu, Y., Li, J., Li, M."WAP four-disulfide core domain protein 2 mediates the proliferation of human ovarian cancer cells through the regulation of growth- and apoptosis-associated genes". Oncology Reports 29.1 (2013): 288-296.
Chicago
Chen, Y., Mu, X., Wang, S., Zhao, L., Wu, Y., Li, J., Li, M."WAP four-disulfide core domain protein 2 mediates the proliferation of human ovarian cancer cells through the regulation of growth- and apoptosis-associated genes". Oncology Reports 29, no. 1 (2013): 288-296. https://doi.org/10.3892/or.2012.2114
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Y, Mu X, Wang S, Zhao L, Wu Y, Li J and Li M: WAP four-disulfide core domain protein 2 mediates the proliferation of human ovarian cancer cells through the regulation of growth- and apoptosis-associated genes. Oncol Rep 29: 288-296, 2013.
APA
Chen, Y., Mu, X., Wang, S., Zhao, L., Wu, Y., Li, J., & Li, M. (2013). WAP four-disulfide core domain protein 2 mediates the proliferation of human ovarian cancer cells through the regulation of growth- and apoptosis-associated genes. Oncology Reports, 29, 288-296. https://doi.org/10.3892/or.2012.2114
MLA
Chen, Y., Mu, X., Wang, S., Zhao, L., Wu, Y., Li, J., Li, M."WAP four-disulfide core domain protein 2 mediates the proliferation of human ovarian cancer cells through the regulation of growth- and apoptosis-associated genes". Oncology Reports 29.1 (2013): 288-296.
Chicago
Chen, Y., Mu, X., Wang, S., Zhao, L., Wu, Y., Li, J., Li, M."WAP four-disulfide core domain protein 2 mediates the proliferation of human ovarian cancer cells through the regulation of growth- and apoptosis-associated genes". Oncology Reports 29, no. 1 (2013): 288-296. https://doi.org/10.3892/or.2012.2114
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