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Review

Pathogenesis and malignant transformation of adenomyosis (Review)

  • Authors:
    • Natsuki Koike
    • Taihei Tsunemi
    • Chiharu Uekuri
    • Juria Akasaka
    • Fuminori Ito
    • Aiko Shigemitsu
    • Hiroshi Kobayashi
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara 634-8522, Japan
  • Pages: 861-867
    |
    Published online on: December 13, 2012
       https://doi.org/10.3892/or.2012.2184
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Abstract

The aim of our review was to identify the current information with regard to the pathogenesis and malignant transformation of adenomyosis. The current literature was reviewed by searching MEDLINE/PubMed, using the following keywords: adenomyosis, myometrium, stromal cells, malignant transformation, pathogenesis, etiology, genome-wide and microarray. Early signs of the development of adenomyosis are considered to be the penetration of stromal cells into the inner layer of the myometrium. Adenomyosis smooth muscle cells are developed, possibly, through a remodeling pathway via reactivation of coelomic epithelial cells as a result of estrogen-induced epithelial mesenchymal transition. Smooth muscle cell hyperplasia and hypertrophy are a reflection of a reaction of the surrounding tissue. The development of adenocarcinoma arising from adenomyosis is a relatively rare occurrence. In our literature review, to date, 44 cases of malignant tumors arising from adenomyosis have been documented. Studies reporting results of genetic abnormalities, epigenetic changes, monoclonal expansion, mutational analysis and the inactivation of specific tumor suppressor genes are very few in this field. In conclusion, adenomyosis can be a precursor of some carcinomas. The exact molecular mechanisms that lead to the malignant transformation are poorly understood.
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Copy and paste a formatted citation
Spandidos Publications style
Koike N, Tsunemi T, Uekuri C, Akasaka J, Ito F, Shigemitsu A and Kobayashi H: Pathogenesis and malignant transformation of adenomyosis (Review). Oncol Rep 29: 861-867, 2013.
APA
Koike, N., Tsunemi, T., Uekuri, C., Akasaka, J., Ito, F., Shigemitsu, A., & Kobayashi, H. (2013). Pathogenesis and malignant transformation of adenomyosis (Review). Oncology Reports, 29, 861-867. https://doi.org/10.3892/or.2012.2184
MLA
Koike, N., Tsunemi, T., Uekuri, C., Akasaka, J., Ito, F., Shigemitsu, A., Kobayashi, H."Pathogenesis and malignant transformation of adenomyosis (Review)". Oncology Reports 29.3 (2013): 861-867.
Chicago
Koike, N., Tsunemi, T., Uekuri, C., Akasaka, J., Ito, F., Shigemitsu, A., Kobayashi, H."Pathogenesis and malignant transformation of adenomyosis (Review)". Oncology Reports 29, no. 3 (2013): 861-867. https://doi.org/10.3892/or.2012.2184
Copy and paste a formatted citation
x
Spandidos Publications style
Koike N, Tsunemi T, Uekuri C, Akasaka J, Ito F, Shigemitsu A and Kobayashi H: Pathogenesis and malignant transformation of adenomyosis (Review). Oncol Rep 29: 861-867, 2013.
APA
Koike, N., Tsunemi, T., Uekuri, C., Akasaka, J., Ito, F., Shigemitsu, A., & Kobayashi, H. (2013). Pathogenesis and malignant transformation of adenomyosis (Review). Oncology Reports, 29, 861-867. https://doi.org/10.3892/or.2012.2184
MLA
Koike, N., Tsunemi, T., Uekuri, C., Akasaka, J., Ito, F., Shigemitsu, A., Kobayashi, H."Pathogenesis and malignant transformation of adenomyosis (Review)". Oncology Reports 29.3 (2013): 861-867.
Chicago
Koike, N., Tsunemi, T., Uekuri, C., Akasaka, J., Ito, F., Shigemitsu, A., Kobayashi, H."Pathogenesis and malignant transformation of adenomyosis (Review)". Oncology Reports 29, no. 3 (2013): 861-867. https://doi.org/10.3892/or.2012.2184
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