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Article

Knockdown of Coronin-1C disrupts Rac1 activation and impairs tumorigenic potential in hepatocellular carcinoma cells

  • Authors:
    • Zhi-Gang Wang
    • Ming-Ku Jia
    • Hong Cao
    • Peng Bian
    • Xue-Dong Fang
  • View Affiliations / Copyright

    Affiliations: The Second Affiliated Hospital of Jilin University, Changchun, Jilin 130041, P.R. China, Changchun Children's Hospital, Changchun, Jilin 130061, P.R. China
  • Pages: 1066-1072
    |
    Published online on: December 28, 2012
       https://doi.org/10.3892/or.2012.2216
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Abstract

Coronin-1C is an important F-actin binding protein which is critical for cell motility. Furthermore, the expression of this protein was found to be increased in diffuse tumors and was correlated with the degree of tumor malignancy. However, the mechanism(s) through which this protein enhances malignancy in hepatocellular carcinoma (HCC) is poorly understood. In this study, we found that Coronin-1C was overexpressed in human HCC tissues compared with the adjacent non-tumor tissues. Overexpression of Coronin-1C enhanced the cell migration in the human HCC cell line BEL-7402, whereas suppressed cell migration and proliferation were observed in Coronin-1C-knockdown BEL-7402 cells together with impaired cell polarity, disrupted cytoskeleton and decreased Rac-1 activation. Moreover, the Coronin-1C knockdown cells displayed a lower degree of malignancy by inducing smaller tumors in nude mice. Thus, we demonstrated a relationship between Coronin-1C overexpression and human HCC growth through enhancement of tumor cell proliferation and migration, which are correlated with Rac-1 activation.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Z, Jia M, Cao H, Bian P and Fang X: Knockdown of Coronin-1C disrupts Rac1 activation and impairs tumorigenic potential in hepatocellular carcinoma cells. Oncol Rep 29: 1066-1072, 2013.
APA
Wang, Z., Jia, M., Cao, H., Bian, P., & Fang, X. (2013). Knockdown of Coronin-1C disrupts Rac1 activation and impairs tumorigenic potential in hepatocellular carcinoma cells. Oncology Reports, 29, 1066-1072. https://doi.org/10.3892/or.2012.2216
MLA
Wang, Z., Jia, M., Cao, H., Bian, P., Fang, X."Knockdown of Coronin-1C disrupts Rac1 activation and impairs tumorigenic potential in hepatocellular carcinoma cells". Oncology Reports 29.3 (2013): 1066-1072.
Chicago
Wang, Z., Jia, M., Cao, H., Bian, P., Fang, X."Knockdown of Coronin-1C disrupts Rac1 activation and impairs tumorigenic potential in hepatocellular carcinoma cells". Oncology Reports 29, no. 3 (2013): 1066-1072. https://doi.org/10.3892/or.2012.2216
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Z, Jia M, Cao H, Bian P and Fang X: Knockdown of Coronin-1C disrupts Rac1 activation and impairs tumorigenic potential in hepatocellular carcinoma cells. Oncol Rep 29: 1066-1072, 2013.
APA
Wang, Z., Jia, M., Cao, H., Bian, P., & Fang, X. (2013). Knockdown of Coronin-1C disrupts Rac1 activation and impairs tumorigenic potential in hepatocellular carcinoma cells. Oncology Reports, 29, 1066-1072. https://doi.org/10.3892/or.2012.2216
MLA
Wang, Z., Jia, M., Cao, H., Bian, P., Fang, X."Knockdown of Coronin-1C disrupts Rac1 activation and impairs tumorigenic potential in hepatocellular carcinoma cells". Oncology Reports 29.3 (2013): 1066-1072.
Chicago
Wang, Z., Jia, M., Cao, H., Bian, P., Fang, X."Knockdown of Coronin-1C disrupts Rac1 activation and impairs tumorigenic potential in hepatocellular carcinoma cells". Oncology Reports 29, no. 3 (2013): 1066-1072. https://doi.org/10.3892/or.2012.2216
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