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Article

Suppression of carbonic anhydrase IX leads to aberrant focal adhesion and decreased invasion of tumor cells

  • Authors:
    • Peter Radvak
    • Marko Repic
    • Eliska Svastova
    • Martina Takacova
    • Lucia Csaderova
    • Hynek Strnad
    • Jaromir Pastorek
    • Silvia Pastorekova
    • Juraj Kopacek
  • View Affiliations / Copyright

    Affiliations: Institute of Virology, Department of Molecular Medicine, Slovak Academy of Sciences, 845 05 Bratislava, Slovak Republic, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, 142 20 Prague 4, Czech Republic
  • Pages: 1147-1153
    |
    Published online on: January 4, 2013
       https://doi.org/10.3892/or.2013.2226
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Abstract

Carbonic anhydrase IX (CA IX) is a well-recognized hypoxia marker with promising diagnostic and therapeutic value. CA IX regulates the pH in hypoxic tumor cells and, thereby, contributes to microenvironmental acidosis and cell migration. To gain a better insight into the molecular processes driven by CA IX, we performed gene expression profiling of HT-1080 fibrosarcoma cells subjected to CA IX depletion by shRNA silencing. We identified the focal adhesion pathway as being significantly inhibited in the absence of CA IX and confirmed this finding by functional assays. Thus, we obtained the first direct evidence for the role of CA IX in focal adhesion.
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Copy and paste a formatted citation
Spandidos Publications style
Radvak P, Repic M, Svastova E, Takacova M, Csaderova L, Strnad H, Pastorek J, Pastorekova S and Kopacek J: Suppression of carbonic anhydrase IX leads to aberrant focal adhesion and decreased invasion of tumor cells. Oncol Rep 29: 1147-1153, 2013.
APA
Radvak, P., Repic, M., Svastova, E., Takacova, M., Csaderova, L., Strnad, H. ... Kopacek, J. (2013). Suppression of carbonic anhydrase IX leads to aberrant focal adhesion and decreased invasion of tumor cells. Oncology Reports, 29, 1147-1153. https://doi.org/10.3892/or.2013.2226
MLA
Radvak, P., Repic, M., Svastova, E., Takacova, M., Csaderova, L., Strnad, H., Pastorek, J., Pastorekova, S., Kopacek, J."Suppression of carbonic anhydrase IX leads to aberrant focal adhesion and decreased invasion of tumor cells". Oncology Reports 29.3 (2013): 1147-1153.
Chicago
Radvak, P., Repic, M., Svastova, E., Takacova, M., Csaderova, L., Strnad, H., Pastorek, J., Pastorekova, S., Kopacek, J."Suppression of carbonic anhydrase IX leads to aberrant focal adhesion and decreased invasion of tumor cells". Oncology Reports 29, no. 3 (2013): 1147-1153. https://doi.org/10.3892/or.2013.2226
Copy and paste a formatted citation
x
Spandidos Publications style
Radvak P, Repic M, Svastova E, Takacova M, Csaderova L, Strnad H, Pastorek J, Pastorekova S and Kopacek J: Suppression of carbonic anhydrase IX leads to aberrant focal adhesion and decreased invasion of tumor cells. Oncol Rep 29: 1147-1153, 2013.
APA
Radvak, P., Repic, M., Svastova, E., Takacova, M., Csaderova, L., Strnad, H. ... Kopacek, J. (2013). Suppression of carbonic anhydrase IX leads to aberrant focal adhesion and decreased invasion of tumor cells. Oncology Reports, 29, 1147-1153. https://doi.org/10.3892/or.2013.2226
MLA
Radvak, P., Repic, M., Svastova, E., Takacova, M., Csaderova, L., Strnad, H., Pastorek, J., Pastorekova, S., Kopacek, J."Suppression of carbonic anhydrase IX leads to aberrant focal adhesion and decreased invasion of tumor cells". Oncology Reports 29.3 (2013): 1147-1153.
Chicago
Radvak, P., Repic, M., Svastova, E., Takacova, M., Csaderova, L., Strnad, H., Pastorek, J., Pastorekova, S., Kopacek, J."Suppression of carbonic anhydrase IX leads to aberrant focal adhesion and decreased invasion of tumor cells". Oncology Reports 29, no. 3 (2013): 1147-1153. https://doi.org/10.3892/or.2013.2226
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