Suppression of carbonic anhydrase IX leads to aberrant focal adhesion and decreased invasion of tumor cells

  • Authors:
    • Peter Radvak
    • Marko Repic
    • Eliska Svastova
    • Martina Takacova
    • Lucia Csaderova
    • Hynek Strnad
    • Jaromir Pastorek
    • Silvia Pastorekova
    • Juraj Kopacek
  • View Affiliations

  • Published online on: January 4, 2013     https://doi.org/10.3892/or.2013.2226
  • Pages: 1147-1153
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Abstract

Carbonic anhydrase IX (CA IX) is a well-recognized hypoxia marker with promising diagnostic and therapeutic value. CA IX regulates the pH in hypoxic tumor cells and, thereby, contributes to microenvironmental acidosis and cell migration. To gain a better insight into the molecular processes driven by CA IX, we performed gene expression profiling of HT-1080 fibrosarcoma cells subjected to CA IX depletion by shRNA silencing. We identified the focal adhesion pathway as being significantly inhibited in the absence of CA IX and confirmed this finding by functional assays. Thus, we obtained the first direct evidence for the role of CA IX in focal adhesion.
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March 2013
Volume 29 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Radvak P, Repic M, Svastova E, Takacova M, Csaderova L, Strnad H, Pastorek J, Pastorekova S and Kopacek J: Suppression of carbonic anhydrase IX leads to aberrant focal adhesion and decreased invasion of tumor cells. Oncol Rep 29: 1147-1153, 2013
APA
Radvak, P., Repic, M., Svastova, E., Takacova, M., Csaderova, L., Strnad, H. ... Kopacek, J. (2013). Suppression of carbonic anhydrase IX leads to aberrant focal adhesion and decreased invasion of tumor cells. Oncology Reports, 29, 1147-1153. https://doi.org/10.3892/or.2013.2226
MLA
Radvak, P., Repic, M., Svastova, E., Takacova, M., Csaderova, L., Strnad, H., Pastorek, J., Pastorekova, S., Kopacek, J."Suppression of carbonic anhydrase IX leads to aberrant focal adhesion and decreased invasion of tumor cells". Oncology Reports 29.3 (2013): 1147-1153.
Chicago
Radvak, P., Repic, M., Svastova, E., Takacova, M., Csaderova, L., Strnad, H., Pastorek, J., Pastorekova, S., Kopacek, J."Suppression of carbonic anhydrase IX leads to aberrant focal adhesion and decreased invasion of tumor cells". Oncology Reports 29, no. 3 (2013): 1147-1153. https://doi.org/10.3892/or.2013.2226