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April 2013 Volume 29 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

NP-1250, an ABCG2 inhibitor, induces apoptotic cell death in mitoxantrone-resistant breast carcinoma MCF7 cells via a caspase-independent pathway

  • Authors:
    • Masumi Ito
    • Kazunori Kajino
    • Masaaki Abe
    • Tsutomu Fujimura
    • Reiko Mineki
    • Takako Ikegami
    • Toshihisa Ishikawa
    • Okio Hino
  • View Affiliations / Copyright

    Affiliations: Department of Pathology and Oncology, Juntendo University School of Medicine, Bunkyo, Tokyo 113-8421, Japan, Laboratory of Proteomics and Biomolecular Science, Biomedical Research Center, Juntendo University Graduate School of Medicine, Bunkyo, Tokyo 113-8421, Japan, Laboratory of Molecular and Biochemical Research, Research Support Center, Juntendo University Graduate School of Medicine, Bunkyo, Tokyo 113-8421, Japan, Omics Science Center, RIKEN Yokohama Institute, Yokohama 230-0045, Japan
  • Pages: 1492-1500
    |
    Published online on: January 24, 2013
       https://doi.org/10.3892/or.2013.2249
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Abstract

Chemoresistance is one of the main obstacles to successful cancer therapy and is frequently associated with multidrug resistance (MDR). One of the most studied mechanisms of MDR is the high expression of ATP-binding cassette (ABC) transporters. Here, we demonstrated that NP-1250, an ABCG2 inhibitor, induced apoptotic cell death in ABCG2-overexpressing multidrug-resistant MCF7/mitoxantrone-resistant (MX) human breast carcinoma cells via a caspase-independent pathway. Incubation of MCF7/MX cells with NP-1250 significantly reduced cell viability, while NP-1250 had little effect on the viability of drug-sensitive MCF7/wild-type cells. Although the target molecules of NP-1250 in cell death remain unknown, investigation of NP-1250 will aid in the elucidation of the molecular mechanism of drug resistance and NP-1250 may become a new therapy for MDR cancers.
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Copy and paste a formatted citation
Spandidos Publications style
Ito M, Kajino K, Abe M, Fujimura T, Mineki R, Ikegami T, Ishikawa T and Hino O: NP-1250, an ABCG2 inhibitor, induces apoptotic cell death in mitoxantrone-resistant breast carcinoma MCF7 cells via a caspase-independent pathway. Oncol Rep 29: 1492-1500, 2013.
APA
Ito, M., Kajino, K., Abe, M., Fujimura, T., Mineki, R., Ikegami, T. ... Hino, O. (2013). NP-1250, an ABCG2 inhibitor, induces apoptotic cell death in mitoxantrone-resistant breast carcinoma MCF7 cells via a caspase-independent pathway. Oncology Reports, 29, 1492-1500. https://doi.org/10.3892/or.2013.2249
MLA
Ito, M., Kajino, K., Abe, M., Fujimura, T., Mineki, R., Ikegami, T., Ishikawa, T., Hino, O."NP-1250, an ABCG2 inhibitor, induces apoptotic cell death in mitoxantrone-resistant breast carcinoma MCF7 cells via a caspase-independent pathway". Oncology Reports 29.4 (2013): 1492-1500.
Chicago
Ito, M., Kajino, K., Abe, M., Fujimura, T., Mineki, R., Ikegami, T., Ishikawa, T., Hino, O."NP-1250, an ABCG2 inhibitor, induces apoptotic cell death in mitoxantrone-resistant breast carcinoma MCF7 cells via a caspase-independent pathway". Oncology Reports 29, no. 4 (2013): 1492-1500. https://doi.org/10.3892/or.2013.2249
Copy and paste a formatted citation
x
Spandidos Publications style
Ito M, Kajino K, Abe M, Fujimura T, Mineki R, Ikegami T, Ishikawa T and Hino O: NP-1250, an ABCG2 inhibitor, induces apoptotic cell death in mitoxantrone-resistant breast carcinoma MCF7 cells via a caspase-independent pathway. Oncol Rep 29: 1492-1500, 2013.
APA
Ito, M., Kajino, K., Abe, M., Fujimura, T., Mineki, R., Ikegami, T. ... Hino, O. (2013). NP-1250, an ABCG2 inhibitor, induces apoptotic cell death in mitoxantrone-resistant breast carcinoma MCF7 cells via a caspase-independent pathway. Oncology Reports, 29, 1492-1500. https://doi.org/10.3892/or.2013.2249
MLA
Ito, M., Kajino, K., Abe, M., Fujimura, T., Mineki, R., Ikegami, T., Ishikawa, T., Hino, O."NP-1250, an ABCG2 inhibitor, induces apoptotic cell death in mitoxantrone-resistant breast carcinoma MCF7 cells via a caspase-independent pathway". Oncology Reports 29.4 (2013): 1492-1500.
Chicago
Ito, M., Kajino, K., Abe, M., Fujimura, T., Mineki, R., Ikegami, T., Ishikawa, T., Hino, O."NP-1250, an ABCG2 inhibitor, induces apoptotic cell death in mitoxantrone-resistant breast carcinoma MCF7 cells via a caspase-independent pathway". Oncology Reports 29, no. 4 (2013): 1492-1500. https://doi.org/10.3892/or.2013.2249
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