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April 2013 Volume 29 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Expression of death receptor-3 in human breast cancer and its functional effects on breast cancer cells in vitro

  • Authors:
    • Zhicheng Ge
    • Andrew J. Sanders
    • Lin Ye
    • Robert E. Mansel
    • Wen G. Jiang
  • View Affiliations / Copyright

    Affiliations: Metastasis and Angiogenesis Research Group, Institute of Cancer and Genetics, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
  • Pages: 1356-1364
    |
    Published online on: January 30, 2013
       https://doi.org/10.3892/or.2013.2259
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Abstract

Death receptor-3 (DR3) plays controversial roles in cancer. Currently, DR3 is known to be a functional receptor of vascular endothelial growth inhibitor (VEGI). The role of DR3 in breast cancer remains unclear. The present study investigated DR3 expression in a clinical cohort of breast cancer patients and its role in breast cancer cells in vitro. The expression of DR3 was examined in a breast cancer cohort using quantitative PCR (Q-PCR) and immunohistochemistry (IHC) in comparison to the patients' data. In vitro function of DR3 was examined through the targeting of this molecule in MCF7 and MDA-MB-231 breast cancer cells using ribozyme transgene technology. Decreased DR3 expression was noted in breast cancer tissues compared to normal tissues and decreased expression of DR3 was generally associated with a poorer prognosis as well as a significantly shorter long-term survival (p=0.038). Targeting of DR3 in vitro in breast cancer cell lines resulted in impaired migratory rates compared to respective control cells. Collectively, these data suggest a complex role for DR3 in breast cancer development and progression.
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Copy and paste a formatted citation
Spandidos Publications style
Ge Z, Sanders AJ, Ye L, Mansel RE and Jiang WG: Expression of death receptor-3 in human breast cancer and its functional effects on breast cancer cells in vitro. Oncol Rep 29: 1356-1364, 2013.
APA
Ge, Z., Sanders, A.J., Ye, L., Mansel, R.E., & Jiang, W.G. (2013). Expression of death receptor-3 in human breast cancer and its functional effects on breast cancer cells in vitro. Oncology Reports, 29, 1356-1364. https://doi.org/10.3892/or.2013.2259
MLA
Ge, Z., Sanders, A. J., Ye, L., Mansel, R. E., Jiang, W. G."Expression of death receptor-3 in human breast cancer and its functional effects on breast cancer cells in vitro". Oncology Reports 29.4 (2013): 1356-1364.
Chicago
Ge, Z., Sanders, A. J., Ye, L., Mansel, R. E., Jiang, W. G."Expression of death receptor-3 in human breast cancer and its functional effects on breast cancer cells in vitro". Oncology Reports 29, no. 4 (2013): 1356-1364. https://doi.org/10.3892/or.2013.2259
Copy and paste a formatted citation
x
Spandidos Publications style
Ge Z, Sanders AJ, Ye L, Mansel RE and Jiang WG: Expression of death receptor-3 in human breast cancer and its functional effects on breast cancer cells in vitro. Oncol Rep 29: 1356-1364, 2013.
APA
Ge, Z., Sanders, A.J., Ye, L., Mansel, R.E., & Jiang, W.G. (2013). Expression of death receptor-3 in human breast cancer and its functional effects on breast cancer cells in vitro. Oncology Reports, 29, 1356-1364. https://doi.org/10.3892/or.2013.2259
MLA
Ge, Z., Sanders, A. J., Ye, L., Mansel, R. E., Jiang, W. G."Expression of death receptor-3 in human breast cancer and its functional effects on breast cancer cells in vitro". Oncology Reports 29.4 (2013): 1356-1364.
Chicago
Ge, Z., Sanders, A. J., Ye, L., Mansel, R. E., Jiang, W. G."Expression of death receptor-3 in human breast cancer and its functional effects on breast cancer cells in vitro". Oncology Reports 29, no. 4 (2013): 1356-1364. https://doi.org/10.3892/or.2013.2259
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