Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
April 2013 Volume 29 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April 2013 Volume 29 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Nestin is highly expressed in advanced-stage melanomas and neurotized nevi

  • Authors:
    • Michiko Akiyama
    • Yoko Matsuda
    • Toshiyuki Ishiwata
    • Zenya Naito
    • Seiji Kawana
  • View Affiliations / Copyright

    Affiliations: Departments of Pathology and Integrative Oncological Pathology, Nippon Medical School, Tokyo 113-8602, Japan, Department of Dermatology, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8603, Japan
  • Pages: 1595-1599
    |
    Published online on: February 15, 2013
       https://doi.org/10.3892/or.2013.2287
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Nestin, a class VI intermediate filament protein, was originally described as a neural stem cell/progenitor cell marker. Expression of nestin has been reported to be associated with the migration and metastasis of various types of tumor. In the present study, we examined the expression of nestin in malignant melanomas and nevi. Immunohistochemically, nestin was detected in all compound nevi, but not in the majority of junctional nevi. Nestin was expressed at particularly high levels in nevi with neurotization. In melanoma, nestin was expressed in all T3 and T4 cases, but only in half of the cases of T2 or less severe disease. These results indicate that the expression levels of nestin in melanoma are associated with advanced disease. In conclusion, nestin was expressed in advanced melanoma tissues and neurotized nevi. Nestin may be an important marker of melanocytic neoplasms. Further studies are required to elucidate the regulatory mechanisms of nestin expression and to examine the possibility of nestin-targeted therapy for malignant melanomas.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 127:2893–2917. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Essner R, Belhocine T, Scott AM and Even-Sapir E: Novel imaging techniques in melanoma. Surg Oncol Clin North Am. 15:253–283. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Kochhar R, Ali H, Mak S and Manoharan P: Metastatic cutaneous malignant melanoma: spectrum of imaging findings and the role of multimodality imaging. J Med Imaging Radiat Oncol. 53:467–478; quiz 478–479. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Lee ML, Tomsu K and Von Eschen KB: Duration of survival for disseminated malignant melanoma: results of a meta-analysis. Melanoma Res. 10:81–92. 2000.PubMed/NCBI

5 

Goozner M: Drug approvals 2011: focus on companion diagnostics. J Natl Cancer Inst. 104:84–86. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Finn L, Markovic SN and Joseph RW: Therapy for metastatic melanoma: the past, present and future. BMC Med. 10:232012. View Article : Google Scholar : PubMed/NCBI

7 

Flaherty KT and Fisher DE: New strategies in metastatic melanoma: oncogene-defined taxonomy leads to therapeutic advances. Clin Cancer Res. 17:4922–4928. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Lendahl U, Zimmerman LB and McKay RD: CNS stem cells express a new class of intermediate filament protein. Cell. 60:585–595. 1990. View Article : Google Scholar : PubMed/NCBI

9 

Sellheyer K and Krahl D: Spatiotemporal expression pattern of neuroepithelial stem cell marker nestin suggests a role in dermal homeostasis, neovasculogenesis and tumor stroma development: a study on embryonic and adult human skin. J Am Acad Dermatol. 63:93–113. 2010. View Article : Google Scholar

10 

Amoh Y, Kanoh M, Niiyama S, et al: Human and mouse hair follicles contain both multipotent and monopotent stem cells. Cell Cycle. 8:176–177. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Amoh Y, Li L, Yang M, et al: Nascent blood vessels in the skin arise from nestin-expressing hair-follicle cells. Proc Natl Acad Sci USA. 101:13291–13295. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Matsuda Y, Naito Z, Kawahara K, Nakazawa N, Korc M and Ishiwata T: Nestin is a novel target for suppressing pancreatic cancer cell migration, invasion and metastasis. Cancer Biol Ther. 11:512–523. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Kawamoto M, Ishiwata T, Cho K, et al: Nestin expression correlates with nerve and retroperitoneal tissue invasion in pancreatic cancer. Hum Pathol. 40:189–198. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Kleeberger W, Bova GS, Nielsen ME, et al: Roles for the stem cell associated intermediate filament Nestin in prostate cancer migration and metastasis. Cancer Res. 67:9199–9206. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Li H, Cherukuri P, Li N, et al: Nestin is expressed in the basal/myoepithelial layer of the mammary gland and is a selective marker of basal epithelial breast tumors. Cancer Res. 67:501–510. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Ishiwata T, Teduka K, Yamamoto T, Kawahara K, Matsuda Y and Naito Z: Neuroepithelial stem cell marker nestin regulates the migration, invasion and growth of human gliomas. Oncol Rep. 26:91–99. 2011.PubMed/NCBI

17 

Yang XH, Wu QL, Yu XB, et al: Nestin expression in different tumours and its relevance to malignant grade. J Clin Pathol. 61:467–473. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Misago N, Mori T and Narisawa Y: Nestin expression in stromal cells of trichoblastoma and basal cell carcinoma. J Eur Acad Dermatol Venereol. 24:1354–1358. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Kanoh M, Amoh Y, Tanabe K, Maejima H, Takasu H and Katsuoka K: Nestin is expressed in HMB-45 negative melanoma cells in dermal parts of nodular melanoma. J Dermatol. 37:505–511. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Abbas O and Bhawan J: Expression of stem cell markers nestin and cytokeratin 15 and 19 in cutaneous malignancies. J Eur Acad Dermatol Venereol. 25:311–316. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Mori T, Misago N, Yamamoto O, Toda S and Narisawa Y: Expression of nestin in dermatofibrosarcoma protuberans in comparison to dermatofibroma. J Dermatol. 35:419–425. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Florenes VA, Holm R, Myklebost O, Lendahl U and Fodstad O: Expression of the neuroectodermal intermediate filament nestin in human melanomas. Cancer Res. 54:354–356. 1994.PubMed/NCBI

23 

Klein WM, Wu BP, Zhao S, Wu H, Klein-Szanto AJ and Tahan SR: Increased expression of stem cell markers in malignant melanoma. Mod Pathol. 20:102–107. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Piras F, Perra MT, Murtas D, et al: The stem cell marker nestin predicts poor prognosis in human melanoma. Oncol Rep. 23:17–24. 2010.PubMed/NCBI

25 

Brychtova S, Fiuraskova M, Hlobilkova A, Brychta T and Hirnak J: Nestin expression in cutaneous melanomas and melanocytic nevi. J Cutan Pathol. 34:370–375. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Tanabe K, Amoh Y, Kanoh M, et al: Prognostic significance of the hair follicle stem cell marker nestin in patients with malignant melanoma. Eur J Dermatol. 20:283–288. 2010.PubMed/NCBI

27 

Mihic-Probst D, Kuster A, Kilgus S, et al: Consistent expression of the stem cell renewal factor BMI-1 in primary and metastatic melanoma. Int J Cancer. 121:1764–1770. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Fusi A, Ochsenreither S, Busse A, Rietz A and Keilholz U: Expression of the stem cell marker nestin in peripheral blood of patients with melanoma. Br J Dermatol. 163:107–114. 2010.PubMed/NCBI

29 

Fusi A, Reichelt U, Busse A, et al: Expression of the stem cell markers nestin and CD133 on circulating melanoma cells. J Invest Dermatol. 131:487–494. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Balch CM, Gershenwald JE, Soong SJ, et al: Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol. 27:6199–6206. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Ackerman AB and Magana-Garcia M: Naming acquired melanocytic nevi. Unna’s, Miescher’s, Spitz’s Clark’s. Am J Dermatopathol. 12:193–209. 1990.

32 

Van Paesschen MA, Goovaerts G and Buyssens N: A study of the so-called neurotization of nevi. Am J Dermatopathol. 12:242–248. 1990.PubMed/NCBI

33 

Misago N: The relationship between melanocytes and peripheral nerve sheath cells (Part I): melanocytic nevus (excluding so-called ‘blue nevus’) with peripheral nerve sheath differentiation. Am J Dermatopathol. 22:217–229. 2000.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Akiyama M, Matsuda Y, Ishiwata T, Naito Z and Kawana S: Nestin is highly expressed in advanced-stage melanomas and neurotized nevi. Oncol Rep 29: 1595-1599, 2013.
APA
Akiyama, M., Matsuda, Y., Ishiwata, T., Naito, Z., & Kawana, S. (2013). Nestin is highly expressed in advanced-stage melanomas and neurotized nevi. Oncology Reports, 29, 1595-1599. https://doi.org/10.3892/or.2013.2287
MLA
Akiyama, M., Matsuda, Y., Ishiwata, T., Naito, Z., Kawana, S."Nestin is highly expressed in advanced-stage melanomas and neurotized nevi". Oncology Reports 29.4 (2013): 1595-1599.
Chicago
Akiyama, M., Matsuda, Y., Ishiwata, T., Naito, Z., Kawana, S."Nestin is highly expressed in advanced-stage melanomas and neurotized nevi". Oncology Reports 29, no. 4 (2013): 1595-1599. https://doi.org/10.3892/or.2013.2287
Copy and paste a formatted citation
x
Spandidos Publications style
Akiyama M, Matsuda Y, Ishiwata T, Naito Z and Kawana S: Nestin is highly expressed in advanced-stage melanomas and neurotized nevi. Oncol Rep 29: 1595-1599, 2013.
APA
Akiyama, M., Matsuda, Y., Ishiwata, T., Naito, Z., & Kawana, S. (2013). Nestin is highly expressed in advanced-stage melanomas and neurotized nevi. Oncology Reports, 29, 1595-1599. https://doi.org/10.3892/or.2013.2287
MLA
Akiyama, M., Matsuda, Y., Ishiwata, T., Naito, Z., Kawana, S."Nestin is highly expressed in advanced-stage melanomas and neurotized nevi". Oncology Reports 29.4 (2013): 1595-1599.
Chicago
Akiyama, M., Matsuda, Y., Ishiwata, T., Naito, Z., Kawana, S."Nestin is highly expressed in advanced-stage melanomas and neurotized nevi". Oncology Reports 29, no. 4 (2013): 1595-1599. https://doi.org/10.3892/or.2013.2287
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team