Nestin is highly expressed in advanced-stage melanomas and neurotized nevi

Akiyama,Michiko; Matsuda,Yoko; Ishiwata,Toshiyuki; Naito,Zenya; Kawana,Seiji

doi:10.3892/or.2013.2287

Nestin is highly expressed in advanced-stage melanomas and neurotized nevi

Authors:
- Michiko Akiyama
- Yoko Matsuda
- Toshiyuki Ishiwata
- Zenya Naito
- Seiji Kawana
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Affiliations: Departments of Pathology and Integrative Oncological Pathology, Nippon Medical School, Tokyo 113-8602, Japan, Department of Dermatology, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8603, Japan
Published online on: February 15, 2013 https://doi.org/10.3892/or.2013.2287
Pages: 1595-1599

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Abstract

Nestin, a class VI intermediate filament protein, was originally described as a neural stem cell/progenitor cell marker. Expression of nestin has been reported to be associated with the migration and metastasis of various types of tumor. In the present study, we examined the expression of nestin in malignant melanomas and nevi. Immunohistochemically, nestin was detected in all compound nevi, but not in the majority of junctional nevi. Nestin was expressed at particularly high levels in nevi with neurotization. In melanoma, nestin was expressed in all T3 and T4 cases, but only in half of the cases of T2 or less severe disease. These results indicate that the expression levels of nestin in melanoma are associated with advanced disease. In conclusion, nestin was expressed in advanced melanoma tissues and neurotized nevi. Nestin may be an important marker of melanocytic neoplasms. Further studies are required to elucidate the regulatory mechanisms of nestin expression and to examine the possibility of nestin-targeted therapy for malignant melanomas.

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