Analysis of genomic aberrations associated with the clinicopathological parameters of rectal cancer by array‑based comparative genomic hybridization

  • Authors:
    • Jian-Wei Liang
    • Zhi-Zhou Shi
    • Tong-Tong Zhang
    • Jia-Jie Hao
    • Zheng Wang
    • Xiao-Min Wang
    • Hai Yang
    • Ming-Rong Wang
    • Zhi-Xiang Zhou
    • Yu Zhang
  • View Affiliations

  • Published online on: February 21, 2013     https://doi.org/10.3892/or.2013.2296
  • Pages: 1827-1834
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Abstract

The aim of the present study was to screen and identify the chromosomal aberrations that are correlated with clinicopathological characteristics of rectal cancer using array-based comparative genomic hybridization (array-CGH). Forty-eight fresh frozen tumor tissues of rectal carcinoma were analyzed by array-CGH. The results showed that most frequent gains included 8q24.3, 20q11.21-q13.32, 20q13.33 and losses in 8p23.3-p12, 17p13.1-p12 and 18q11.2-q23 were noted. Fourteen amplifications and seven homozygous deletions were identified in the rectal cancer samples. Losses of 4p16.1-p15.31, 8p21.1-p12 and gains of 7p12.3-p12.1 and 13q33.1-q34 were associated with positive lymph node status and advanced clinical stage (stages III and IV). The 17q24.2-25.3 gain was more frequent in patients with distant metastasis. Integrated analysis indicated that overexpression of PDP1, TRIB1, C13orf27, FOXA2, PMEPA1 and PHACTR3 was associated with gains, and underexpression of FHOD, SMAD4 and BCL2 was associated with losses. Pathway enrichment analysis showed that pathways of nitrogen metabolism, oxidative phosphorylation, cell cycle, maturity onset diabetes of young, cytokine-cytokine receptor interaction, MAPK signaling pathway and dentatorubropallidoluysian atrophy were influenced by copy number changes.
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May 2013
Volume 29 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Liang J, Shi Z, Zhang T, Hao J, Wang Z, Wang X, Yang H, Wang M, Zhou Z, Zhang Y, Zhang Y, et al: Analysis of genomic aberrations associated with the clinicopathological parameters of rectal cancer by array‑based comparative genomic hybridization. Oncol Rep 29: 1827-1834, 2013
APA
Liang, J., Shi, Z., Zhang, T., Hao, J., Wang, Z., Wang, X. ... Zhang, Y. (2013). Analysis of genomic aberrations associated with the clinicopathological parameters of rectal cancer by array‑based comparative genomic hybridization. Oncology Reports, 29, 1827-1834. https://doi.org/10.3892/or.2013.2296
MLA
Liang, J., Shi, Z., Zhang, T., Hao, J., Wang, Z., Wang, X., Yang, H., Wang, M., Zhou, Z., Zhang, Y."Analysis of genomic aberrations associated with the clinicopathological parameters of rectal cancer by array‑based comparative genomic hybridization". Oncology Reports 29.5 (2013): 1827-1834.
Chicago
Liang, J., Shi, Z., Zhang, T., Hao, J., Wang, Z., Wang, X., Yang, H., Wang, M., Zhou, Z., Zhang, Y."Analysis of genomic aberrations associated with the clinicopathological parameters of rectal cancer by array‑based comparative genomic hybridization". Oncology Reports 29, no. 5 (2013): 1827-1834. https://doi.org/10.3892/or.2013.2296