Journal Articles

Open Access

PARP1 gene expression is downregulated by knockdown of PARG gene

Fumiaki Uchiumi, Takeshi Watanabe, Ryo Ohta, Hideaki Abe, Sei-Ichi Tanuma

Pages: 1683-1688 Published online on: 04 March 2013
Open Access

Synergistic cytotoxic effects of inorganic phosphate and chemotherapeutic drugs on human osteosarcoma cells

Annamaria Spina, Luca Sorvillo, Emilio Chiosi, Antonietta Esposito, Francesca Di Maiolo, Luigi Sapio, Michele Caraglia, Silvio Naviglio

Pages: 1689-1696 Published online on: 26 February 2013
Open Access

Sequence mutations of the substrate binding pocket of stem cell factor and multidrug resistance protein ABCG2 in renal cell cancer: A possible link to treatment resistance

Inka Zoernig, Claudia Ziegelmeier, Bernd Lahrmann, Niels  Grabe, Dirk Jäger, Niels Halama

Pages: 1697-1700 Published online on: 05 March 2013
Open Access

Overexpression of SENP3 in oral squamous cell carcinoma and its association with differentiation

Zujun Sun, Shuiqing Hu, Qingqiong Luo, Dongxia Ye, Dan Hu, Fuxiang Chen

Pages: 1701-1706 Published online on: 01 March 2013
Open Access

Efficacy of goserelin plus anastrozole in premenopausal women with advanced or recurrent breast cancer refractory to an LH-RH analogue with tamoxifen: Results of the JMTO BC08-01 phase II trial

Reiki Nishimura, Keisei Anan, Yutaka Yamamoto, Kenji Higaki, Maki  Tanaka, Kenji Shibuta, Yasuaki Sagara, Shinji Ohno, Shigeru  Tsuyuki, Takahiro Mase, Satoshi Teramukai

Pages: 1707-1713 Published online on: 27 February 2013
Open Access

Inhibition of the SK-N-MC human neuroblastoma cell line in vivo and in vitro by a novel nutrient mixture

M. Waheed Roomi, Tatiana Kalinovsky, Nusrath W. Roomi, Aleksandra Niedzwiecki, Matthias Rath

Pages: 1714-1720 Published online on: 27 February 2013
Open Access

RNA interference-mediated FANCF silencing sensitizes OVCAR3 ovarian cancer cells to adriamycin through increased adriamycin-induced apoptosis dependent on JNK activation

Miao He, Hai-Gang Sun, Jun-Ying Hao, Yan-Lin Li, Jian-Kun Yu, Yuan-Yuan Yan, Lin Zhao, Na Li, Yan Wang, Xue-Feng Bai, Zhao-Jin Yu, Zhi-Hong Zheng, Xiao-Yi Mi, En-Hua Wang, Min-Jie Wei

Pages: 1721-1729 Published online on: 21 February 2013
Open Access

Expression of HAUSP in gliomas correlates with disease progression and survival of patients

Chuandong Cheng, Chaoshi Niu, Yang Yang, Yang Wang, Manman Lu

Pages: 1730-1736 Published online on: 12 March 2013

The expression and function of Toll-like receptors 3 and 9 in human colon carcinoma

Keiichiro Nojiri, Kazushi Sugimoto, Katsuya Shiraki, Masahiko Tameda, Yuuji Inagaki, Satoko Kusagawa, Suguru Ogura, Junichiro Tanaka, Misao Yoneda, Norihiko Yamamoto, Hiroshi Okano, Yoshiyuki Takei, Masaaki Ito, Chika Kasai, Hidekazu Inoue, Koujiro Takase

Pages: 1737-1743 Published online on: 04 March 2013

Antiproliferative activity of gambogic acid isolated from Garcinia hanburyi in Hep3B and Huh7 cancer cells

Parry Ngan Hon Lee, Wing Shing Ho

Pages: 1744-1750 Published online on: 19 February 2013

Low-dose dacarbazine-doxorubicin therapy against intra-abdominal desmoid tumors

Hirofumi Yamamoto, Ryota Oshiro, Junichi Nishimura, Mamoru Uemura, Naotsugu Haraguchi, Taishi Hata, Ichiro Takemasa, Tsunekazu Mizushima, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

Pages: 1751-1755 Published online on: 13 March 2013

Clinical impact of tumor-infiltrating CD45RO+ memory T cells on human gastric cancer

Kohei Wakatsuki, Masayuki Sho, Ichiro Yamato, Tomoyoshi Takayama, Sohei Matsumoto, Tetsuya Tanaka, Kazuhiro Migita, Masahiro Ito, Kiyohiko Hotta, Yoshiyuki Nakajima

Pages: 1756-1762 Published online on: 22 February 2013

Prognostic value of cancer stem cells, epithelial-mesenchymal transition and circulating tumor cells in lung cancer

G. Pirozzi, V. Tirino, R. Camerlingo, A. La Rocca, N. Martucci, G. Scognamiglio, R. Franco, M. Cantile, N. Normanno, G. Rocco

Pages: 1763-1768 Published online on: 19 February 2013

miRNA-181b increases the sensitivity of pancreatic ductal adenocarcinoma cells to gemcitabine in vitro and in nude mice by targeting BCL-2

Baobao Cai, Yong An, Nan Lv, Jianmin Chen, Min Tu, Jie Sun, Pengfei Wu, Jishu Wei, Kuirong Jiang, Yi Miao

Pages: 1769-1776 Published online on: 21 February 2013

ALDH1-positive cancer stem-like cells are enriched in nodal metastases of oropharyngeal squamous cell carcinoma independent of HPV status

Xu Qian, Steffen Wagner, Chenming Ma, Jens P. Klussmann, Michael Hummel, Andreas M. Kaufmann, Andreas E. Albers

Pages: 1777-1784 Published online on: 11 March 2013

Inhibition of Cdk2 activity decreases Aurora-A kinase centrosomal localization and prevents centrosome amplification in breast cancer cells

Alexey A. Leontovich, Jeffrey L. Salisbury, Massimiliano Veroux, Tiziano Tallarita, Daniel Billadeau, James McCubrey, James Ingle, Evanthia Galanis, Antonino B. D'Assoro

Pages: 1785-1788 Published online on: 27 February 2013

Lentiviral-mediated gene silencing of Notch-4 inhibits in vitro proliferation and perineural invasion of ACC-M cells

Wei Chen, Huali Zhang, Jiandong Wang, Gang Cao, Zhen Dong, Han Su, Xiaojun Zhou, Senlin Zhang

Pages: 1797-1804 Published online on: 28 February 2013

Copper induces cellular senescence in human glioblastoma multiforme cells through downregulation of Bmi-1

Yuan Li, Jifan Hu, Fangxia Guan, Laijun Song, Ruitai Fan, Huaijie Zhu, Xiang Hu, Eileen Shen, Bo Yang

Pages: 1805-1810 Published online on: 06 March 2013

Metastasin leads to poor prognosis of hepatocellular carcinoma through partly inducing EMT

Xin Zheng, Xiaohong Gai, Zhenhua Wu, Qingguang Liu, Yingmin Yao

Pages: 1811-1818 Published online on: 12 March 2013

Genome-wide analysis of DNA methylation in tongue squamous cell carcinoma

Sheng Zhang, Xiang-Ling Feng, Lei Shi, Chao-Jian Gong, Zhi-Jing He, Han-Jiang Wu, Tian-You Ling

Pages: 1819-1826 Published online on: 27 February 2013

Analysis of genomic aberrations associated with the clinicopathological parameters of rectal cancer by array‑based comparative genomic hybridization

Jian-Wei Liang, Zhi-Zhou Shi, Tong-Tong Zhang, Jia-Jie Hao, Zheng Wang, Xiao-Min Wang, Hai Yang, Ming-Rong Wang, Zhi-Xiang Zhou, Yu Zhang

Pages: 1827-1834 Published online on: 21 February 2013

Cytokine-induced killer cells co-cultured with complete tumor antigen-loaded dendritic cells, have enhanced selective cytotoxicity on carboplatin-resistant retinoblastoma cells

Ya-Feng Wang, Patricia E. Kunda, Jian-Wei Lin, Han Wang, Xue-Mei Chen, Qiu-Ling Liu, Tao Liu

Pages: 1841-1850 Published online on: 28 February 2013

Synergistic anticancer effects of curcumin and resveratrol in Hepa1-6 hepatocellular carcinoma cells

Qin Du, Bing Hu, Hong-Mei An, Ke-Ping Shen, Ling Xu, Shan Deng, Meng-Meng Wei

Pages: 1851-1858 Published online on: 27 February 2013

Livistona chinensis seed suppresses hepatocellular carcinoma growth through promotion of mitochondrial-dependent apoptosis

Wei Lin, Jinyan Zhao, Zhiyun Cao, Qunchuan Zhuang, Liangpu Zheng, Qiaoyan Cai, Daxin Chen, Lili Wang, Zhenfeng Hong, Jun Peng

Pages: 1859-1866 Published online on: 01 March 2013

Core binding factor acute myeloid leukaemia and c-KIT mutations

Ludovica Riera, Filippo Marmont, Daniela Toppino, Chiara  Frairia, Francesca  Sismondi, Ernesta Audisio, Cristiana Di Bello, Stefano  D'Ardia, Paola  Francia Di Celle, Emanuela Messa, Giorgio Inghirami, Umberto Vitolo, Achille Pich

Pages: 1867-1872 Published online on: 05 March 2013

Progesterone inhibits the migration and invasion of A549 lung cancer cells through membrane progesterone receptor α-mediated mechanisms

Mingxuan Xie, Shaojin You, Qiong Chen, Xi Chen, Chengping Hu

Pages: 1873-1880 Published online on: 06 March 2013

Huntingtin-associated protein 1: A potential biomarker of breast cancer

Liwei Zhu, Xue Song, Jinhai Tang, Jianzhong Wu, Rong Ma, Haixia Cao, Minghua Ji, Changwen Jing, Zhuo Wang

Pages: 1881-1887 Published online on: 22 February 2013

Heparanase is involved in the proliferation and invasion of nasopharyngeal carcinoma cells

Jinzhang Chen, Dayong Zheng, Jie Shen, Jian Ruan, Aimin Li, Wenmin Li, Guozhu Xie, Xiaojun Luo, Peng Zhao, Hang Zheng

Pages: 1888-1894 Published online on: 05 March 2013

Inhibition of extracellular signal-regulated kinase activity by sorafenib increases sensitivity to DNR in K562 cells

Ruo-Zhi Xiao, Cheng-Ming He, Mu-Jun Xiong, Xing-Xing Ruan, Li-Lin Wang, Yan Chen, Dong-Jun Lin

Pages: 1895-1901 Published online on: 06 March 2013

Gene expression profiling and molecular pathway analysis for the identification of early-stage lung adenocarcinoma patients at risk for early recurrence

Hisashi Saji, Masahiro Tsuboi, Yoshihisa Shimada, Yasufumi Kato, Wakako Hamanaka, Yujin Kudo, Koichi Yoshida, Jun Matsubayashi, Jitsuo Usuda, Tatsuo Ohira, Norihiko Ikeda

Pages: 1902-1906 Published online on: 06 March 2013

Impact of acetylsalicylic acid on tumor angiogenesis and lymphangiogenesis through inhibition of VEGF signaling in a murine sarcoma model

Xiaoyue Zhang, Zhaopeng Wang, Zhaoxia Wang, Yueying Zhang, Qing Jia, Licun Wu, Weidong Zhang

Pages: 1907-1913 Published online on: 11 March 2013

High susceptibility of heterozygous (+/fa) lean Zucker rats to 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis

Toshio Imai, Young-Man Cho, Mami Takahashi, Tsukasa Kitahashi, Shigeaki Takami, Akiyoshi Nishikawa, Kumiko Ogawa

Pages: 1914-1922 Published online on: 05 March 2013

Sorting, identification and enrichment of side population cells in THP-1 acute monocytic leukemia cells

Yingchao Wang, Chuyun Yin, Lei Feng, Lina Ma, Yongwei Wei, Guangyao Sheng

Pages: 1923-1931 Published online on: 28 February 2013

miRNA-22 suppresses colon cancer cell migration and invasion by inhibiting the expression of T-cell lymphoma invasion and metastasis 1 and matrix metalloproteinases 2 and 9

Bo Li, Yan Song, Tong-Jun Liu, You-Bin Cui, Yang Jiang, Zhong-Shi Xie, Shu-Li Xie

Pages: 1932-1938 Published online on: 22 February 2013

Study of the mechanisms underlying the reversal of multidrug resistance of human neuroblastoma multidrug-resistant cell line SK-N-SH/MDR1 by low-intensity pulsed ultrasound

Yanhui Sun, Qin Li, Youhua Xu, Conglun Pu, Lihua Zhao, Zhenhua Guo, Xionghui Ding, Xianqing Jin

Pages: 1939-1945 Published online on: 07 March 2013

Low methylation levels of the SFRP1 gene are associated with the basal-like subtype of breast cancer

Young Ju Jeong, Hye Yeon Jeong, Jin Gu Bong, Sung Hwan Park, Hoon Kyu Oh

Pages: 1946-1954 Published online on: 06 March 2013

Peptide FLNPDVLDI of heparanase is a novel HLA-A2-restricted CTL epitope and elicits potent immunological antitumor effects in vitro with an 8-branched design

Jun Zhang, Jianmin Yang, Daiming Fan, Houquan Tao, Huiju Wang, Tong Yu

Pages: 1955-1961 Published online on: 13 March 2013

Human papillomavirus infection in head and neck cancer: The role of the secretory leukocyte protease inhibitor

Markus Hoffmann, Elgar S. Quabius, Silke Tribius, Lena Hebebrand, Tibor Görögh, Gordana Halec, Tomas Kahn, Jürgen Hedderich, Christoph Röcken, Jochen Haag, Tim Waterboer, Markus Schmitt, Anna R. Giuliano, W. Martin Kast

Pages: 1962-1968 Published online on: 05 March 2013

Prognostic and therapeutic implications of mTORC1 and Rictor expression in human breast cancer

U. Wazir, R. F. Newbold, W. G. Jiang, A. K. Sharma, K. Mokbel

Pages: 1969-1974 Published online on: 13 March 2013

Blockade of DNA methylation enhances the therapeutic effect of gefitinib in non-small cell lung cancer cells

Xiao-You Li, Jian-Zhong Wu, Hai-Xia Cao, Rong Ma, Jian-Qiu Wu, Yue-Jiao Zhong, Ji-Feng Feng

Pages: 1975-1982 Published online on: 21 February 2013

Epigallocatechin gallate promotes p53 accumulation and activity via the inhibition of MDM2-mediated p53 ubiquitination in human lung cancer cells

Longyu Jin, Cui Li, Yan Xu, Li Wang, Jianxin Liu, Dianjun Wang, Cao  Hong, Zhibing Jiang, Yuchao Ma, Qian Chen, Fenglei Yu

Pages: 1983-1990 Published online on: 12 March 2013

Identification of plant extracts sensitizing breast cancer cells to TRAIL

Sherif Abdelhamed, Satoru Yokoyama, Lia Hafiyani, Surya K. Kalauni, Yoshihiro Hayakawa, Suresh Awale, Ikuo Saiki

Pages: 1991-1998 Published online on: 19 February 2013

Cyclooxygenase-2 is induced by p38 MAPK and promotes cell survival

Rosanna Parente, Elisabetta Trifirò, Francesca Cuozzo, Sandro Valia, Mara Cirone, Livia Di Renzo

Pages: 1999-2004 Published online on: 27 February 2013

Prevalence of underlying lung disease in smokers with epidermal growth factor receptor-mutant lung cancer

Akimasa Sekine, Katsumi Tamura, Hiroaki Satoh, Tomoaki Tanaka, Yoshiya Tsunoda, Toru Tanaka, Hiroyuki Takoi, Shih-Yuan Lin, Yohei Yatagai, Toshinori Hashizume, Kenji Hayasihara, Takefumi Saito

Pages: 2005-2010 Published online on: 01 March 2013

A novel c-Met inhibitor, MK8033, synergizes with carboplatin plus paclitaxel to inhibit ovarian cancer cell growth

Douglas C. Marchion, Elona Bicaku, Yin Xiong, Nadim Bou Zgheib, Entidhar Al Sawah, Xiaomang Ba Stickles, Patricia L. Judson, Alex S. Lopez, Christopher L. Cubitt, Jesus Gonzalez-Bosquet, Robert M. Wenham, Sachin M. Apte, Anders Berglund, Johnathan M. Lancaster

Pages: 2011-2018 Published online on: 05 March 2013

miR-101 inhibits autophagy and enhances cisplatin-induced apoptosis in hepatocellular carcinoma cells

Yonghua Xu, Yong An, Yun Wang, Changhe Zhang, Hai Zhang, Changjun Huang, Hao Jiang, Xuehao Wang, Xiangcheng Li

Pages: 2019-2024 Published online on: 07 March 2013

Zinc-α2-glycoprotein: A proliferative factor for breast cancer? In vitro study and molecular mechanisms

Laetitia Delort, Stéphane Perrier, Virginie Dubois, Hermine Billard, Tomas Mracek, Chen Bing, Marie-Paule Vasson, Florence Caldefie-Chézet

Pages: 2025-2029 Published online on: 27 February 2013

Genetic inhibition of vascular endothelial growth factor receptor-1 significantly inhibits the migration and proliferation of leukemia cells and increases their sensitivity to chemotherapy

Bing Xiu, Wenjun Zhang, Binbin Huang, Jingde Chen, Huina Lu, Jianfei Fu, Hong Xiong, Aibin Liang

Pages: 2030-2038 Published online on: 13 March 2013

Effect of histone deacetylase and DNA methyltransferase inhibitors on the expression of the androgen receptor gene in androgen-independent prostate cancer cell lines

Barbora Fialova, Katerina Smesny Trtkova, Lenka Paskova, Katerina Langova, Zdenek Kolar

Pages: 2039-2045 Published online on: 13 March 2013

Leukemia cells demonstrate a different metabolic perturbation provoked by 2-deoxyglucose

Hiroshi Miwa, Masato Shikami, Mineaki Goto, Shohei Mizuno, Miyuki Takahashi, Norikazu Tsunekawa-Imai, Takamasa Ishikawa, Motonori Mizutani, Tomohiro Horio, Mayuko Gotou, Hidesuke Yamamoto, Motohiro Wakabayashi, Masaya Watarai, Ichiro Hanamura, Akira Imamura, Hidetsugu Mihara, Masakazu Nitta

Pages: 2053-2057 Published online on: 21 February 2013

Melatonin modulates aromatase activity and expression in endothelial cells

Virginia Alvarez-García, Alicia González, Carlos Martínez-Campa, Carolina Alonso-González, Samuel Cos

Pages: 2058-2064 Published online on: 28 February 2013

Promising anti-leukemic activity of atorvastatin

Jolanta D. Żołnierczyk, Arleta Borowiak, Paweł Hikisz, Barbara Cebula-Obrzut, Jerzy Z. Błoński, Piotr Smolewski, Tadeusz Robak, Zofia M. Kiliańska

Pages: 2065-2071 Published online on: 22 February 2013

Indirubin-3'-monoxime promotes autophagic and apoptotic death in JM1 human acute lymphoblastic leukemia cells and K562 human chronic myelogenous leukemia cells

Ming-Yang Lee, Yi-Wen Liu, Ming-Ho Chen, Jin-Yi Wu, Hsing‑Ying  Ho, Qwa-Fun Wang, Jing-Jing Chuang

Pages: 2072-2078 Published online on: 06 March 2013

Let-7: A regulator of the ERα signaling pathway in human breast tumors and breast cancer stem cells

Xin Sun, Sida Qin, Chong Fan, Chongwen Xu, Ning Du, Hong Ren

Pages: 2079-2087 Published online on: 06 March 2013
Journal Cover

May 2013
Volume 29 Issue 5

Print ISSN: 1021-335X
Online ISSN: 1791-2431

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