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Article

Clinical impact of tumor-infiltrating CD45RO+ memory T cells on human gastric cancer

  • Authors:
    • Kohei Wakatsuki
    • Masayuki Sho
    • Ichiro Yamato
    • Tomoyoshi Takayama
    • Sohei Matsumoto
    • Tetsuya Tanaka
    • Kazuhiro Migita
    • Masahiro Ito
    • Kiyohiko Hotta
    • Yoshiyuki Nakajima
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Nara Medical University, Nara 634-8522, Japan
  • Pages: 1756-1762
    |
    Published online on: February 22, 2013
       https://doi.org/10.3892/or.2013.2302
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Abstract

Memory T cells survive for months and even years and are critical for host defense in humans. They have been recently suggested to play a significant role in tumor immunity. In this study, we aimed to investigate the clinical impact of tumor-infiltrating memory T cells on human gastric cancer. We evaluated CD45RO+ T cells infiltrating into primary gastric cancer tissues by immunohistochemistry in 101 patients with gastric cancer. Patients were classified into 2 groups (CD45RO+Hi and CD45RO+Lo) based on the number of positively stained T cells. There was no significant correlation observed between CD45RO status and post-operative prognosis in early gastric cancer. By contrast, in advanced cancer, the post-operative overall and disease-free survival of patients with CD45RO+Hi were significantly improved compared to those of patients with CD45RO+Lo. In addition, CD45RO status in the primary tumors significantly correlated with the development of post-operative recurrence, particularly peritoneal recurrence. Furthermore, the local expression of interferon-γ (IFN-γ) in the CD45RO+Hi tumors was significantly higher than that in the CD45RO+Lo tumors, suggesting that CD45RO+ T cells induced local immune activation. Multivariate analysis indicated that the CD45RO+ status was an independent prognostic factor in advanced gastric cancer. In conclusion, tumor-infiltrating CD45RO+ memory T cells are functional and have significant prognostic value in human gastric cancer. Our data suggest that adaptive immune response is clinically critical in gastric cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Wakatsuki K, Sho M, Yamato I, Takayama T, Matsumoto S, Tanaka T, Migita K, Ito M, Hotta K, Nakajima Y, Nakajima Y, et al: Clinical impact of tumor-infiltrating CD45RO+ memory T cells on human gastric cancer. Oncol Rep 29: 1756-1762, 2013.
APA
Wakatsuki, K., Sho, M., Yamato, I., Takayama, T., Matsumoto, S., Tanaka, T. ... Nakajima, Y. (2013). Clinical impact of tumor-infiltrating CD45RO+ memory T cells on human gastric cancer. Oncology Reports, 29, 1756-1762. https://doi.org/10.3892/or.2013.2302
MLA
Wakatsuki, K., Sho, M., Yamato, I., Takayama, T., Matsumoto, S., Tanaka, T., Migita, K., Ito, M., Hotta, K., Nakajima, Y."Clinical impact of tumor-infiltrating CD45RO+ memory T cells on human gastric cancer". Oncology Reports 29.5 (2013): 1756-1762.
Chicago
Wakatsuki, K., Sho, M., Yamato, I., Takayama, T., Matsumoto, S., Tanaka, T., Migita, K., Ito, M., Hotta, K., Nakajima, Y."Clinical impact of tumor-infiltrating CD45RO+ memory T cells on human gastric cancer". Oncology Reports 29, no. 5 (2013): 1756-1762. https://doi.org/10.3892/or.2013.2302
Copy and paste a formatted citation
x
Spandidos Publications style
Wakatsuki K, Sho M, Yamato I, Takayama T, Matsumoto S, Tanaka T, Migita K, Ito M, Hotta K, Nakajima Y, Nakajima Y, et al: Clinical impact of tumor-infiltrating CD45RO+ memory T cells on human gastric cancer. Oncol Rep 29: 1756-1762, 2013.
APA
Wakatsuki, K., Sho, M., Yamato, I., Takayama, T., Matsumoto, S., Tanaka, T. ... Nakajima, Y. (2013). Clinical impact of tumor-infiltrating CD45RO+ memory T cells on human gastric cancer. Oncology Reports, 29, 1756-1762. https://doi.org/10.3892/or.2013.2302
MLA
Wakatsuki, K., Sho, M., Yamato, I., Takayama, T., Matsumoto, S., Tanaka, T., Migita, K., Ito, M., Hotta, K., Nakajima, Y."Clinical impact of tumor-infiltrating CD45RO+ memory T cells on human gastric cancer". Oncology Reports 29.5 (2013): 1756-1762.
Chicago
Wakatsuki, K., Sho, M., Yamato, I., Takayama, T., Matsumoto, S., Tanaka, T., Migita, K., Ito, M., Hotta, K., Nakajima, Y."Clinical impact of tumor-infiltrating CD45RO+ memory T cells on human gastric cancer". Oncology Reports 29, no. 5 (2013): 1756-1762. https://doi.org/10.3892/or.2013.2302
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