Clinical impact of tumor-infiltrating CD45RO+ memory T cells on human gastric cancer

  • Authors:
    • Kohei Wakatsuki
    • Masayuki Sho
    • Ichiro Yamato
    • Tomoyoshi Takayama
    • Sohei Matsumoto
    • Tetsuya Tanaka
    • Kazuhiro Migita
    • Masahiro Ito
    • Kiyohiko Hotta
    • Yoshiyuki Nakajima
  • View Affiliations

  • Published online on: February 22, 2013     https://doi.org/10.3892/or.2013.2302
  • Pages: 1756-1762
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Memory T cells survive for months and even years and are critical for host defense in humans. They have been recently suggested to play a significant role in tumor immunity. In this study, we aimed to investigate the clinical impact of tumor-infiltrating memory T cells on human gastric cancer. We evaluated CD45RO+ T cells infiltrating into primary gastric cancer tissues by immunohistochemistry in 101 patients with gastric cancer. Patients were classified into 2 groups (CD45RO+Hi and CD45RO+Lo) based on the number of positively stained T cells. There was no significant correlation observed between CD45RO status and post-operative prognosis in early gastric cancer. By contrast, in advanced cancer, the post-operative overall and disease-free survival of patients with CD45RO+Hi were significantly improved compared to those of patients with CD45RO+Lo. In addition, CD45RO status in the primary tumors significantly correlated with the development of post-operative recurrence, particularly peritoneal recurrence. Furthermore, the local expression of interferon-γ (IFN-γ) in the CD45RO+Hi tumors was significantly higher than that in the CD45RO+Lo tumors, suggesting that CD45RO+ T cells induced local immune activation. Multivariate analysis indicated that the CD45RO+ status was an independent prognostic factor in advanced gastric cancer. In conclusion, tumor-infiltrating CD45RO+ memory T cells are functional and have significant prognostic value in human gastric cancer. Our data suggest that adaptive immune response is clinically critical in gastric cancer.
View Figures
View References

Related Articles

Journal Cover

May 2013
Volume 29 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wakatsuki K, Sho M, Yamato I, Takayama T, Matsumoto S, Tanaka T, Migita K, Ito M, Hotta K, Nakajima Y, Nakajima Y, et al: Clinical impact of tumor-infiltrating CD45RO+ memory T cells on human gastric cancer. Oncol Rep 29: 1756-1762, 2013
APA
Wakatsuki, K., Sho, M., Yamato, I., Takayama, T., Matsumoto, S., Tanaka, T. ... Nakajima, Y. (2013). Clinical impact of tumor-infiltrating CD45RO+ memory T cells on human gastric cancer. Oncology Reports, 29, 1756-1762. https://doi.org/10.3892/or.2013.2302
MLA
Wakatsuki, K., Sho, M., Yamato, I., Takayama, T., Matsumoto, S., Tanaka, T., Migita, K., Ito, M., Hotta, K., Nakajima, Y."Clinical impact of tumor-infiltrating CD45RO+ memory T cells on human gastric cancer". Oncology Reports 29.5 (2013): 1756-1762.
Chicago
Wakatsuki, K., Sho, M., Yamato, I., Takayama, T., Matsumoto, S., Tanaka, T., Migita, K., Ito, M., Hotta, K., Nakajima, Y."Clinical impact of tumor-infiltrating CD45RO+ memory T cells on human gastric cancer". Oncology Reports 29, no. 5 (2013): 1756-1762. https://doi.org/10.3892/or.2013.2302