Huntingtin-associated protein 1: A potential biomarker of breast cancer

  • Authors:
    • Liwei Zhu
    • Xue Song
    • Jinhai Tang
    • Jianzhong Wu
    • Rong Ma
    • Haixia Cao
    • Minghua Ji
    • Changwen Jing
    • Zhuo Wang
  • View Affiliations

  • Published online on: February 22, 2013     https://doi.org/10.3892/or.2013.2303
  • Pages: 1881-1887
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

It is reported that patients with Huntington's disease (HD) have a low incidence of cancer. In this study, we investigated the expression of huntingtin-associated protein 1 (HAP1), the ligand of HD's production, in breast tumor and normal tissues. We found that HAP1 expression was significantly lower in tumor compared to normal tissues. We then transfected the HAP1 gene into the breast cancer lines MCF-7 and MDA-MB-231, and results showed that the overexpression of HAP1 reduced the growth of the two cell lines. In addition, we observed that HAP1 also reduced invasion and migration, and upregulated apoptosis in MCF-7 cells; however, these changes were not observed in MDA-MB-231 cells. We also demonstrated that the expression of EGFR and apoptosis-related genes might be involved in cell proliferation and apoptosis. In conclusion, overexpression of HAP1 reduced in vitro cell growth in breast cancer cell lines, suppressed the migration and invasion, and promoted the apoptosis of certain cell lines. Therefore, HAP1 is a potential molecular target for the diagnosis and treatment of breast cancer.
View Figures
View References

Related Articles

Journal Cover

May 2013
Volume 29 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhu L, Song X, Tang J, Wu J, Ma R, Cao H, Ji M, Jing C and Wang Z: Huntingtin-associated protein 1: A potential biomarker of breast cancer. Oncol Rep 29: 1881-1887, 2013
APA
Zhu, L., Song, X., Tang, J., Wu, J., Ma, R., Cao, H. ... Wang, Z. (2013). Huntingtin-associated protein 1: A potential biomarker of breast cancer. Oncology Reports, 29, 1881-1887. https://doi.org/10.3892/or.2013.2303
MLA
Zhu, L., Song, X., Tang, J., Wu, J., Ma, R., Cao, H., Ji, M., Jing, C., Wang, Z."Huntingtin-associated protein 1: A potential biomarker of breast cancer". Oncology Reports 29.5 (2013): 1881-1887.
Chicago
Zhu, L., Song, X., Tang, J., Wu, J., Ma, R., Cao, H., Ji, M., Jing, C., Wang, Z."Huntingtin-associated protein 1: A potential biomarker of breast cancer". Oncology Reports 29, no. 5 (2013): 1881-1887. https://doi.org/10.3892/or.2013.2303