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Article

Cyclooxygenase-2 is induced by p38 MAPK and promotes cell survival

  • Authors:
    • Rosanna Parente
    • Elisabetta Trifirò
    • Francesca Cuozzo
    • Sandro Valia
    • Mara Cirone
    • Livia Di Renzo
  • View Affiliations / Copyright

    Affiliations: Department of Experimental Medicine, University of Rome ‘La Sapienza’, I-00161 Rome, Italy
  • Pages: 1999-2004
    |
    Published online on: February 27, 2013
       https://doi.org/10.3892/or.2013.2308
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Abstract

The Na+ ionophore monensin affects cellular pH and, depending on its concentration, causes the survival or death of tumor cells. In the present study, we elucidated the survival pathway activated in U937 cells, a human lymphoma-derived cell line. These cells treated with monensin at a concentration of 5 µM were growth-arrested in G1, activated p38 mitogen-activated protein kinase (MAPK) and showed an increased expression of cyclooxygenase-2 (COX-2). The latter two molecular events were linked, as pharmacological inhibition of the MAPK did not allow COX-2 increased expression. Furthermore, we showed that p38 and COX-2 keep monensin-stressed U937 cells alive, as pharmacological inhibition of each enzyme caused cell death.
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Copy and paste a formatted citation
Spandidos Publications style
Parente R, Trifirò E, Cuozzo F, Valia S, Cirone M and Di Renzo L: Cyclooxygenase-2 is induced by p38 MAPK and promotes cell survival. Oncol Rep 29: 1999-2004, 2013.
APA
Parente, R., Trifirò, E., Cuozzo, F., Valia, S., Cirone, M., & Di Renzo, L. (2013). Cyclooxygenase-2 is induced by p38 MAPK and promotes cell survival. Oncology Reports, 29, 1999-2004. https://doi.org/10.3892/or.2013.2308
MLA
Parente, R., Trifirò, E., Cuozzo, F., Valia, S., Cirone, M., Di Renzo, L."Cyclooxygenase-2 is induced by p38 MAPK and promotes cell survival". Oncology Reports 29.5 (2013): 1999-2004.
Chicago
Parente, R., Trifirò, E., Cuozzo, F., Valia, S., Cirone, M., Di Renzo, L."Cyclooxygenase-2 is induced by p38 MAPK and promotes cell survival". Oncology Reports 29, no. 5 (2013): 1999-2004. https://doi.org/10.3892/or.2013.2308
Copy and paste a formatted citation
x
Spandidos Publications style
Parente R, Trifirò E, Cuozzo F, Valia S, Cirone M and Di Renzo L: Cyclooxygenase-2 is induced by p38 MAPK and promotes cell survival. Oncol Rep 29: 1999-2004, 2013.
APA
Parente, R., Trifirò, E., Cuozzo, F., Valia, S., Cirone, M., & Di Renzo, L. (2013). Cyclooxygenase-2 is induced by p38 MAPK and promotes cell survival. Oncology Reports, 29, 1999-2004. https://doi.org/10.3892/or.2013.2308
MLA
Parente, R., Trifirò, E., Cuozzo, F., Valia, S., Cirone, M., Di Renzo, L."Cyclooxygenase-2 is induced by p38 MAPK and promotes cell survival". Oncology Reports 29.5 (2013): 1999-2004.
Chicago
Parente, R., Trifirò, E., Cuozzo, F., Valia, S., Cirone, M., Di Renzo, L."Cyclooxygenase-2 is induced by p38 MAPK and promotes cell survival". Oncology Reports 29, no. 5 (2013): 1999-2004. https://doi.org/10.3892/or.2013.2308
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