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Overexpression of SENP3 in oral squamous cell carcinoma and its association with differentiation

  • Authors:
    • Zujun Sun
    • Shuiqing Hu
    • Qingqiong Luo
    • Dongxia Ye
    • Dan Hu
    • Fuxiang Chen
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratories, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China, Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 1701-1706
    |
    Published online on: March 1, 2013
       https://doi.org/10.3892/or.2013.2318
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Abstract

Small ubiquitin-like modifier (SUMO) modification is an important post-translational protein modification that can be reversed by SUMO-specific proteases (SENPs); however, the physiological function of SENPs remains largely unexplored, and little is known about the regulation of SENPs themselves. As one of the crucial members of the SUMO system, SENP3 is essential for rRNA processing and cell proliferation. In the present study, we analysed the expression of SENP3 in human oral squamous cell carcinoma (OSCC) and investigated the correlation between its expression and clinicopathological parameters in OSCC patients. The expression of SENP3 was higher in OSCC tissues than that in the normal mucosa adjacent to the tumor, and a modest increase in reactive oxygen species (ROS) regulated SENP3 stability and localization. ROS induced SENP3 redistribution from the nucleoli to the nucleoplasm. Taken together, these results indicated that the expression level of SENP3 may be associated with the differentiation of OSCC and that SENP3 may play an important role in the development of OSCC under oxidative stress.
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Copy and paste a formatted citation
Spandidos Publications style
Sun Z, Hu S, Luo Q, Ye D, Hu D and Chen F: Overexpression of SENP3 in oral squamous cell carcinoma and its association with differentiation. Oncol Rep 29: 1701-1706, 2013.
APA
Sun, Z., Hu, S., Luo, Q., Ye, D., Hu, D., & Chen, F. (2013). Overexpression of SENP3 in oral squamous cell carcinoma and its association with differentiation. Oncology Reports, 29, 1701-1706. https://doi.org/10.3892/or.2013.2318
MLA
Sun, Z., Hu, S., Luo, Q., Ye, D., Hu, D., Chen, F."Overexpression of SENP3 in oral squamous cell carcinoma and its association with differentiation". Oncology Reports 29.5 (2013): 1701-1706.
Chicago
Sun, Z., Hu, S., Luo, Q., Ye, D., Hu, D., Chen, F."Overexpression of SENP3 in oral squamous cell carcinoma and its association with differentiation". Oncology Reports 29, no. 5 (2013): 1701-1706. https://doi.org/10.3892/or.2013.2318
Copy and paste a formatted citation
x
Spandidos Publications style
Sun Z, Hu S, Luo Q, Ye D, Hu D and Chen F: Overexpression of SENP3 in oral squamous cell carcinoma and its association with differentiation. Oncol Rep 29: 1701-1706, 2013.
APA
Sun, Z., Hu, S., Luo, Q., Ye, D., Hu, D., & Chen, F. (2013). Overexpression of SENP3 in oral squamous cell carcinoma and its association with differentiation. Oncology Reports, 29, 1701-1706. https://doi.org/10.3892/or.2013.2318
MLA
Sun, Z., Hu, S., Luo, Q., Ye, D., Hu, D., Chen, F."Overexpression of SENP3 in oral squamous cell carcinoma and its association with differentiation". Oncology Reports 29.5 (2013): 1701-1706.
Chicago
Sun, Z., Hu, S., Luo, Q., Ye, D., Hu, D., Chen, F."Overexpression of SENP3 in oral squamous cell carcinoma and its association with differentiation". Oncology Reports 29, no. 5 (2013): 1701-1706. https://doi.org/10.3892/or.2013.2318
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