Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
May 2013 Volume 29 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May 2013 Volume 29 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Prevalence of underlying lung disease in smokers with epidermal growth factor receptor-mutant lung cancer

  • Authors:
    • Akimasa Sekine
    • Katsumi Tamura
    • Hiroaki Satoh
    • Tomoaki Tanaka
    • Yoshiya Tsunoda
    • Toru Tanaka
    • Hiroyuki Takoi
    • Shih-Yuan Lin
    • Yohei Yatagai
    • Toshinori Hashizume
    • Kenji Hayasihara
    • Takefumi Saito
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, National Hospital Organization, Ibarakihigashi National Hospital, Naka-gun, Ibaraki 319-1113, Japan, Department of Radiology, National Hospital Organization, Ibarakihigashi National Hospital, Naka-gun, Ibaraki 319-1113, Japan, Department of Internal Medicine, Mito Medical Center, University of Tsukuba, Mito, Ibaraki 310-0015, Japan, Department of Respiratory Medicine, Saitama Medical School, Iruma‑gun, Saitama 350-0400, Japan, Department of General Thoracic Surgery, National Hospital Organization, Ibarakihigashi National Hospital, Naka-gun, Ibaraki 319-1113, Japan
  • Pages: 2005-2010
    |
    Published online on: March 1, 2013
       https://doi.org/10.3892/or.2013.2320
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The prevalence of underlying lung diseases, such as emphysema and interstitial lung disease in smokers with epidermal growth factor receptor (EGFR)-mutant lung cancer remains unclear. This study aimed to clarify the correlation between the EGFR mutation status and the prevalence of underlying lung disease in smokers with lung cancer. A total of 88 consecutive smokers with non-small cell or non-squamous cell lung cancer who underwent surgical resection at our hospital from January 2007 through December 2010 were included in this study. The patients were divided into two groups on the basis of the EGFR mutation status: the mutation-positive group (n=19) and the wild-type group (n=69). The results of radiographic assessment via computed tomography (CT) and pulmonary function analysis were compared between the two groups. In the radiological evaluation, CT images at three levels were evaluated by two reviewers. Radiographic assessment revealed that the mutation-positive group tended to have milder emphysematous changes and a lower prevalence of interstitial changes compared with the wild-type group (P=0.13, 0.06). When the analysis was limited to the ipsilateral lung at the nearest CT level to the tumor, emphysematous changes were found to be less common in the mutation-positive group (P=0.02). The prevalence of the emphysematous and/or interstitial changes in the ipsilateral lung at the nearest CT level to the tumor was lower in the mutation-positive group compared to the wild-type group (P=0.005). In the pulmonary function test, the results were comparable between the two groups. In conclusion, according to our results, EGFR-mutant lung cancer was commonly observed in the areas where emphysematous and interstitial changes were absent. EGFR-mutant lung cancer may develop in radiographically normal areas of the lungs, even in smokers. It would be of importance to evaluate the EGFR mutation status in patients with no emphysematous or interstitial changes in the ipsilateral lung near the tumor, regardless of their smoking history. These results should be confirmed in a future prospective study.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Wynder EL and Graham EA: Landmark article May 27, 1950: Tobacco Smoking as a possible etiologic factor in bronchiogenic carcinoma. A study of six hundred and eighty-four proved cases. By Ernest L. Wynder and Evarts A. Graham. JAMA. 253:2986–2994. 1985. View Article : Google Scholar

2 

Schiller JH, Harrington D, Belani CP, et al: Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med. 346:92–98. 2002. View Article : Google Scholar

3 

Ohe Y, Ohashi Y, Kubota K, et al: Randomized phase III study of cisplatin plus irinotecan versus carboplatin plus paclitaxel, cisplatin plus gemcitabine, and cisplatin plus vinorelbine for advanced non-small-cell lung cancer: Four-Arm Cooperative Study in Japan. Ann Oncol. 18:317–323. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Paez JG, Janne PA, Lee JC, et al: EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 304:1497–1500. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Lynch TJ, Bell DW, Sordella R, et al: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 350:2129–2139. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Kosaka T, Yatabe Y, Endoh H, Kuwano H, Takahashi T and Mitsudomi T: Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications. Cancer Res. 64:8919–8923. 2004. View Article : Google Scholar

7 

Lee YJ, Shim HS, Kang YA, et al: Dose effect of cigarette smoking on frequency and spectrum of epidermal growth factor receptor gene mutations in Korean patients with non-small cell lung cancer. J Cancer Res Clin Oncol. 136:1937–1944. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Pham D, Kris MG, Riely GJ, et al: Use of cigarette-smoking history to estimate the likelihood of mutations in epidermal growth factor receptor gene exons 19 and 21 in lung adenocarcinomas. J Clin Oncol. 24:1700–1704. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Jida M, Toyooka S, Mitsudomi T, et al: Usefulness of cumulative smoking dose for identifying the EGFR mutation and patients with non-small-cell lung cancer for gefitinib treatment. Cancer Sci. 100:1931–1934. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Wilson DO, Weissfeld JL, Balkan A, et al: Association of radiographic emphysema and airflow obstruction with lung cancer. Am J Respir Crit Care Med. 178:738–744. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Maldonado F, Bartholmai BJ, Swensen SJ, Midthun DE, Decker PA and Jett JR: Are airflow obstruction and radiographic evidence of emphysema risk factors for lung cancer? A nested case-control study using quantitative emphysema analysis. Chest. 138:1295–1302. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Cottin V, Nunes H, Brillet PY, et al: Combined pulmonary fibrosis and emphysema: a distinct underrecognised entity. Eur Respir J. 26:586–593. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Usui K, Tanai C, Tanaka Y, Noda H and Ishihara T: The prevalence of pulmonary fibrosis combined with emphysema in patients with lung cancer. Respirology. 16:326–331. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Kitaguchi Y, Fujimoto K, Hanaoka M, Kawakami S, Honda T and Kubo K: Clinical characteristics of combined pulmonary fibrosis and emphysema. Respirology. 15:265–271. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Kenmotsu H, Naito T, Kimura M, et al: The risk of cytotoxic chemotherapy-related exacerbation of interstitial lung disease with lung cancer. J Thorac Oncol. 6:1242–1246. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Goddard PR, Nicholson EM, Laszlo G and Watt I: Computed tomography in pulmonary emphysema. Clin Radiol. 33:379–387. 1982. View Article : Google Scholar : PubMed/NCBI

17 

Bergin C, Muller N, Nichols DM, et al: The diagnosis of emphysema. A computed tomographic-pathologic correlation. Am Rev Respir Dis. 133:541–546. 1986.PubMed/NCBI

18 

Ferguson GT, Enright PL, Buist AS and Higgins MW: Office spirometry for lung health assessment in adults: A consensus statement from the National Lung Health Education Program. Chest. 117:1146–1161. 2000. View Article : Google Scholar

19 

Nagai Y, Miyazawa H, Huqun, et al: Genetic heterogeneity of the epidermal growth factor receptor in non-small cell lung cancer cell lines revealed by a rapid and sensitive detection system, the peptide nucleic acid-locked nucleic acid PCR clamp. Cancer Res. 65:7276–7282. 2005. View Article : Google Scholar

20 

Takano T, Ohe Y, Sakamoto H, et al: Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer. J Clin Oncol. 23:6829–6837. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Lee YJ, Cho BC, Jee SH, et al: Impact of environmental tobacco smoke on the incidence of mutations in epidermal growth factor receptor gene in never-smoker patients with non-small-cell lung cancer. J Clin Oncol. 28:487–492. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Usui K, Ushijima T, Tanaka Y, et al: The frequency of epidermal growth factor receptor mutation of nonsmall cell lung cancer according to the underlying pulmonary diseases. Pulm Med. 2011:2901322011. View Article : Google Scholar : PubMed/NCBI

23 

Gullon JA, Suarez I, Medina A, Rubinos G, Fernandez R and Gonzalez I: Role of emphysema and airway obstruction in prognosis of lung cancer. Lung Cancer. 71:182–185. 2011. View Article : Google Scholar

24 

de Torres JP, Bastarrika G, Wisnivesky JP, et al: Assessing the relationship between lung cancer risk and emphysema detected on low-dose CT of the chest. Chest. 132:1932–1938. 2007.PubMed/NCBI

25 

Smith BM, Pinto L, Ezer N, Sverzellati N, Muro S and Schwartzman K: Emphysema detected on computed tomography and risk of lung cancer: a systematic review and meta-analysis. Lung Cancer. 77:58–63. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Yamada N, Yamaya M, Okinaga S, et al: Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema. Am J Hum Genet. 66:187–195. 2000. View Article : Google Scholar : PubMed/NCBI

27 

Kikuchi A, Yamaya M, Suzuki S, et al: Association of susceptibility to the development of lung adenocarcinoma with the heme oxygenase-1 gene promoter polymorphism. Hum Genet. 116:354–360. 2005. View Article : Google Scholar : PubMed/NCBI

28 

D'Angelo SP, Pietanza MC, Johnson ML, et al: Incidence of EGFR exon 19 deletions and L858R in tumor specimens from men and cigarette smokers with lung adenocarcinomas. J Clin Oncol. 29:2066–2070. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Morita S, Okamoto I, Kobayashi K, et al: Combined survival analysis of prospective clinical trials of gefitinib for non-small cell lung cancer with EGFR mutations. Clin Cancer Res. 15:4493–4498. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Rosell R, Moran T, Queralt C, et al: Screening for epidermal growth factor receptor mutations in lung cancer. N Engl J Med. 361:958–967. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Sanchez-Cespedes M, Ahrendt SA, Piantadosi S, et al: Chromosomal alterations in lung adenocarcinoma from smokers and nonsmokers. Cancer Res. 61:1309–1313. 2001.PubMed/NCBI

32 

Shukuya T, Takahashi T, Kaira R, et al: Efficacy of gefitinib for non-adenocarcinoma non-small-cell lung cancer patients harboring epidermal growth factor receptor mutations: a pooled analysis of published reports. Cancer Sci. 102:1032–1037. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Castillo L, Etienne-Grimaldi MC, Fischel JL, Formento P, Magne N and Milano G: Pharmacological background of EGFR targeting. Ann Oncol. 15:1007–1012. 2004. View Article : Google Scholar : PubMed/NCBI

34 

Kudoh S, Kato H, Nishiwaki Y, et al: Interstitial lung disease in Japanese patients with lung cancer: a cohort and nested case-control study. Am J Respir Crit Care Med. 177:1348–1357. 2008. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Sekine A, Tamura K, Satoh H, Tanaka T, Tsunoda Y, Tanaka T, Takoi H, Lin S, Yatagai Y, Hashizume T, Hashizume T, et al: Prevalence of underlying lung disease in smokers with epidermal growth factor receptor-mutant lung cancer. Oncol Rep 29: 2005-2010, 2013.
APA
Sekine, A., Tamura, K., Satoh, H., Tanaka, T., Tsunoda, Y., Tanaka, T. ... Saito, T. (2013). Prevalence of underlying lung disease in smokers with epidermal growth factor receptor-mutant lung cancer. Oncology Reports, 29, 2005-2010. https://doi.org/10.3892/or.2013.2320
MLA
Sekine, A., Tamura, K., Satoh, H., Tanaka, T., Tsunoda, Y., Tanaka, T., Takoi, H., Lin, S., Yatagai, Y., Hashizume, T., Hayasihara, K., Saito, T."Prevalence of underlying lung disease in smokers with epidermal growth factor receptor-mutant lung cancer". Oncology Reports 29.5 (2013): 2005-2010.
Chicago
Sekine, A., Tamura, K., Satoh, H., Tanaka, T., Tsunoda, Y., Tanaka, T., Takoi, H., Lin, S., Yatagai, Y., Hashizume, T., Hayasihara, K., Saito, T."Prevalence of underlying lung disease in smokers with epidermal growth factor receptor-mutant lung cancer". Oncology Reports 29, no. 5 (2013): 2005-2010. https://doi.org/10.3892/or.2013.2320
Copy and paste a formatted citation
x
Spandidos Publications style
Sekine A, Tamura K, Satoh H, Tanaka T, Tsunoda Y, Tanaka T, Takoi H, Lin S, Yatagai Y, Hashizume T, Hashizume T, et al: Prevalence of underlying lung disease in smokers with epidermal growth factor receptor-mutant lung cancer. Oncol Rep 29: 2005-2010, 2013.
APA
Sekine, A., Tamura, K., Satoh, H., Tanaka, T., Tsunoda, Y., Tanaka, T. ... Saito, T. (2013). Prevalence of underlying lung disease in smokers with epidermal growth factor receptor-mutant lung cancer. Oncology Reports, 29, 2005-2010. https://doi.org/10.3892/or.2013.2320
MLA
Sekine, A., Tamura, K., Satoh, H., Tanaka, T., Tsunoda, Y., Tanaka, T., Takoi, H., Lin, S., Yatagai, Y., Hashizume, T., Hayasihara, K., Saito, T."Prevalence of underlying lung disease in smokers with epidermal growth factor receptor-mutant lung cancer". Oncology Reports 29.5 (2013): 2005-2010.
Chicago
Sekine, A., Tamura, K., Satoh, H., Tanaka, T., Tsunoda, Y., Tanaka, T., Takoi, H., Lin, S., Yatagai, Y., Hashizume, T., Hayasihara, K., Saito, T."Prevalence of underlying lung disease in smokers with epidermal growth factor receptor-mutant lung cancer". Oncology Reports 29, no. 5 (2013): 2005-2010. https://doi.org/10.3892/or.2013.2320
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team