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Article

High susceptibility of heterozygous (+/fa) lean Zucker rats to 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis

  • Authors:
    • Toshio Imai
    • Young-Man Cho
    • Mami Takahashi
    • Tsukasa Kitahashi
    • Shigeaki Takami
    • Akiyoshi Nishikawa
    • Kumiko Ogawa
  • View Affiliations / Copyright

    Affiliations: Central Animal Division, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan, Division of Pathology, National Institute of Health Sciences, Setagaya-ku, Tokyo 158-8501, Japan
  • Pages: 1914-1922
    |
    Published online on: March 5, 2013
       https://doi.org/10.3892/or.2013.2326
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Abstract

Susceptibility to 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinogenesis was investigated in lean Zucker (+/fa) rats carrying one mutated leptin receptor gene and wild-type controls (+/+). Rats with both genotypes were given a single DMBA administration and divided into two groups, one group was fed on basal diet mixed with 10% corn oil and the other was fed on basal diet alone. The minimum latency period of palpable carcinomas in +/fa rats of both groups was 8 weeks following DMBA treatment, in contrast to the 11-12 weeks in +/+. The incidence and multiplicity of carcinomas increased or showed a tendency for increase in the early stages in +/fa rats of both groups as compared to the +/+ counterparts. The volumes of carcinomas showed a tendency to increase in the corn oil diet groups of both genotypes. The major histopathological phenotype of carcinomas in all groups was well-differentiated without distinct atypia (multiplicity, 0.69-1.09/rat), but moderately/poorly differentiated carcinomas with atypia were also found, predominantly in +/fa rats (0.09-0.21). These latter tumors were characterized by elevated ERK activity but not estrogen receptor expression. Serum leptin concentrations in +/fa rats at 7 weeks of age were higher than those in +/+ and were elevated by the corn oil diet; however, no obvious change was detected in other serum parameters examined. In conclusion, +/fa rats proved more susceptible to DMBA-induced mammary carcinogenesis than +/+ controls, and hyperleptinemia was suggested to contribute to tumor growth as well as to susceptibility to tumorigenesis and more aggressive phenotypes in Zucker lean rats.
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Copy and paste a formatted citation
Spandidos Publications style
Imai T, Cho Y, Takahashi M, Kitahashi T, Takami S, Nishikawa A and Ogawa K: High susceptibility of heterozygous (+/fa) lean Zucker rats to 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis. Oncol Rep 29: 1914-1922, 2013.
APA
Imai, T., Cho, Y., Takahashi, M., Kitahashi, T., Takami, S., Nishikawa, A., & Ogawa, K. (2013). High susceptibility of heterozygous (+/fa) lean Zucker rats to 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis. Oncology Reports, 29, 1914-1922. https://doi.org/10.3892/or.2013.2326
MLA
Imai, T., Cho, Y., Takahashi, M., Kitahashi, T., Takami, S., Nishikawa, A., Ogawa, K."High susceptibility of heterozygous (+/fa) lean Zucker rats to 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis". Oncology Reports 29.5 (2013): 1914-1922.
Chicago
Imai, T., Cho, Y., Takahashi, M., Kitahashi, T., Takami, S., Nishikawa, A., Ogawa, K."High susceptibility of heterozygous (+/fa) lean Zucker rats to 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis". Oncology Reports 29, no. 5 (2013): 1914-1922. https://doi.org/10.3892/or.2013.2326
Copy and paste a formatted citation
x
Spandidos Publications style
Imai T, Cho Y, Takahashi M, Kitahashi T, Takami S, Nishikawa A and Ogawa K: High susceptibility of heterozygous (+/fa) lean Zucker rats to 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis. Oncol Rep 29: 1914-1922, 2013.
APA
Imai, T., Cho, Y., Takahashi, M., Kitahashi, T., Takami, S., Nishikawa, A., & Ogawa, K. (2013). High susceptibility of heterozygous (+/fa) lean Zucker rats to 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis. Oncology Reports, 29, 1914-1922. https://doi.org/10.3892/or.2013.2326
MLA
Imai, T., Cho, Y., Takahashi, M., Kitahashi, T., Takami, S., Nishikawa, A., Ogawa, K."High susceptibility of heterozygous (+/fa) lean Zucker rats to 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis". Oncology Reports 29.5 (2013): 1914-1922.
Chicago
Imai, T., Cho, Y., Takahashi, M., Kitahashi, T., Takami, S., Nishikawa, A., Ogawa, K."High susceptibility of heterozygous (+/fa) lean Zucker rats to 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis". Oncology Reports 29, no. 5 (2013): 1914-1922. https://doi.org/10.3892/or.2013.2326
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