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Article

Downregulation of Sp1 is involved in honokiol-induced cell cycle arrest and apoptosis in human malignant pleural mesothelioma cells

  • Authors:
    • Jung-Il Chae
    • Young-Joo Jeon
    • Jung-Hyun Shim
  • View Affiliations / Copyright

    Affiliations: Department of Dental Pharmacology, School of Dentistry, Brain Korea 21 Project, Chonbuk National University, Jeonju 561‑756, Republic of Korea, College of Pharmacy, Mokpo National University, Muan, Jeonnam 534-729, Republic of Korea
  • Pages: 2318-2324
    |
    Published online on: March 20, 2013
       https://doi.org/10.3892/or.2013.2353
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Abstract

Malignant pleural mesothelioma (MPM) is an extremely aggressive type of cancer and is associated with a poor patient prognosis due to its rapid progression. Novel therapeutic agents such as honokiol (HNK) improve the clinical outcomes of cancer therapy, yet the mechanisms involved have not been fully elucidated. The present study examined the regulatory effects of HNK on the growth and apoptosis of MSTO-211H mesothelioma cells and investigated its anticancer mechanism. The results revealed that HNK significantly reduced the cell viability and increased the sub-G1 population in MSTO-211H cells and suppressed the expression of the specificity protein 1 protein (Sp1). HNK reduced the transcriptional activity of Sp1 regulatory proteins, including cyclin D1, Mcl-1 and survivin, and, thus, induced apoptosis signaling pathways by increasing Bax, reducing Bid and Bcl-xl and activating caspase-3 and PARP in mesothelioma cells. The results suggest that Sp1, a novel molecular target of HNK, may be related to cell cycle arrest and apoptosis induction through the modulation of signal transduction pathways in MPM.
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Copy and paste a formatted citation
Spandidos Publications style
Chae J, Jeon Y and Shim J: Downregulation of Sp1 is involved in honokiol-induced cell cycle arrest and apoptosis in human malignant pleural mesothelioma cells. Oncol Rep 29: 2318-2324, 2013.
APA
Chae, J., Jeon, Y., & Shim, J. (2013). Downregulation of Sp1 is involved in honokiol-induced cell cycle arrest and apoptosis in human malignant pleural mesothelioma cells. Oncology Reports, 29, 2318-2324. https://doi.org/10.3892/or.2013.2353
MLA
Chae, J., Jeon, Y., Shim, J."Downregulation of Sp1 is involved in honokiol-induced cell cycle arrest and apoptosis in human malignant pleural mesothelioma cells". Oncology Reports 29.6 (2013): 2318-2324.
Chicago
Chae, J., Jeon, Y., Shim, J."Downregulation of Sp1 is involved in honokiol-induced cell cycle arrest and apoptosis in human malignant pleural mesothelioma cells". Oncology Reports 29, no. 6 (2013): 2318-2324. https://doi.org/10.3892/or.2013.2353
Copy and paste a formatted citation
x
Spandidos Publications style
Chae J, Jeon Y and Shim J: Downregulation of Sp1 is involved in honokiol-induced cell cycle arrest and apoptosis in human malignant pleural mesothelioma cells. Oncol Rep 29: 2318-2324, 2013.
APA
Chae, J., Jeon, Y., & Shim, J. (2013). Downregulation of Sp1 is involved in honokiol-induced cell cycle arrest and apoptosis in human malignant pleural mesothelioma cells. Oncology Reports, 29, 2318-2324. https://doi.org/10.3892/or.2013.2353
MLA
Chae, J., Jeon, Y., Shim, J."Downregulation of Sp1 is involved in honokiol-induced cell cycle arrest and apoptosis in human malignant pleural mesothelioma cells". Oncology Reports 29.6 (2013): 2318-2324.
Chicago
Chae, J., Jeon, Y., Shim, J."Downregulation of Sp1 is involved in honokiol-induced cell cycle arrest and apoptosis in human malignant pleural mesothelioma cells". Oncology Reports 29, no. 6 (2013): 2318-2324. https://doi.org/10.3892/or.2013.2353
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