Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
June 2013 Volume 29 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June 2013 Volume 29 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Bilateral nerve sparing robotic-assisted radical prostatectomy is associated with faster continence recovery but not with erectile function recovery compared with retropubic open prostatectomy: The need for accurate selection of patients

  • Authors:
    • Giuseppe Mario Ludovico
    • Giuseppe Dachille
    • Giovanni Pagliarulo
    • Carolina D'Elia
    • Nicola Mondaini
    • Mauro Gacci
    • Beatrice Detti
    • Gianni Malossini
    • Riccardo Bartoletti
    • Tommaso Cai
  • View Affiliations / Copyright

    Affiliations: Department of Urology and Robotic Surgery, Miulli Hospital, Acquaviva delle Fonti, Bari, Italy, Department of Urology, San Giacomo Hospital, Monopoli, Bari, Italy, Department of Urology, Santa Chiara Hospital, Trento, Italy, Department of Urology, Santa Maria Annunziata Hospital, Florence, Italy, Department of Urology, Careggi Hospital, University of Florence, Florence, Italy, Radiotherapy Unit, Careggi Hospital, University of Florence, Florence, Italy
  • Pages: 2445-2450
    |
    Published online on: March 26, 2013
       https://doi.org/10.3892/or.2013.2365
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Robotic-assisted radical prostatectomy (RARP) shows measurable advantages, compared to conventional open surgery, even if some aspects are, still, under debate. The aim of this study was to compare the potency recovery rate of patients with clinically localised prostate cancer treated by bilateral nerve-sparing (BNS) RARP or retropubic radical prostatectomy (RRP), and secondarily, the urinary continence recovery evaluation and the oncological efficacy. All patients treated with BNS-RARP or BNS-RRP for clinically localised prostate cancer, performed by a single dedicated surgeon, between January 2004 and December 2008, were enrolled in this non-randomised prospective comparative study. The International Index of Erectile Function (IIEF) and erection hardness score (EHS), in the form of a questionnaire, were self-administered to each patient pre-operatively and after 12 months. The presence of surgical margins was considered as oncological outcome measure. Eighty-two patients underwent BNS-RARP while 48 underwent BNS-RRP. For BNS-RARP and BNS-RRP the median operative time was 221 and 103 min, respectively (P<0.001; df=128; t=721.43),and intra-operative blood loss was 280 and 565 ml, respectively (P<0.001; df=128; t=1742.44). At a mean follow-up period of 12.4±2.3 months, 12 patients (25%) in the BNS-RRP group and 22 (26.8%) in the BNS-RARP group were considered potent with or without drugs (P=0.81). Moreover, we did not find any statistically significant difference between the 2 groups in terms of IEFF and EHS scores after treatment (17.21 vs. 16.98; P=0.16 and 2.1 vs. 2.0; P=0.54). On the other hand, statistically significant differences between the 2 groups were found in terms of faster urinary continence recovery and the presence of positive surgical margins (P<0.001, P=0.009). Shorter catheterization duration (7 vs. 3 days) and post-operative hospital stays (8 vs. 4 days; P<0.001) were found in the BNS-RARP group compared to the BNS-RRP group. In conclusion, our results demonstrate that BNS-RARP does not improve erectile function recovery compared to open radical prostatectomy; however, it significantly improves urinary continence and decreases the presence of positive surgical margins.
View Figures
View References

1 

Heidenreich A, Bellmunt J, Bolla M, Joniau S, Mason M, Matveev V, Mottet N, Schmid HP, van der Kwast T, Wiegel T and Zattoni F; European Association of Urology. EAU guidelines on prostate cancer. Part 1: screening, diagnosis, and treatment of clinically localised disease. Eur Urol. 59:61–71. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Magheli A and Burnett AL: Erectile dysfunction following prostatectomy: prevention and treatment. Nat Rev Urol. 6:415–427. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Ficarra V, Novarra G, Artibani W, Cestari A, Galfano A, Graefen M, Guazzoni G, Guillonneau B, Menon M, Montorsi F, et al: Retropubic, laparoscopic, and robot-assisted radical prostatectomy: a systematic review and cumulative analysis of comparative studies. Eur Urol. 55:1037–1063. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Ou YC, Yang CR, Wang J, Cheng CL and Patel VR: Comparison of robotic-assisted versus retropubic radical prostatectomy performed by a single surgeon. Anticancer Res. 29:1637–1642. 2009.PubMed/NCBI

5 

Menon M, Muhletaler F, Campos M and Peabody JO: Assesment of early continence after reconstruction of the periprostatic tissues in patients undergoing computer assisted (robotic) prostatectomy: results of a 2 group parallel randomized controlled trial. J Urol. 180:1018–1023. 2008. View Article : Google Scholar

6 

Krambeck AE, DiMarco DS and Rangel LJ: Radical prostatectomy for prostatic adenocarcinoma: a matched comparision of open retropubic and robot-assisted techniques. BUJ Int. 103:488–453. 2009.PubMed/NCBI

7 

Jaffe J, Castellucci S, Cathelineau X, Harmon J, Rozet F, Barret E and Vallancien G: Robot-assisted laparoscopic prostatectomy: a single institution’s learning curve. Urology. 73:127–133. 2009.

8 

Greene FL, Page DL, Fleming ID, et al: AJCC Cancer Staging Manual. 6th edition. Springer-Verlag; New York: 2002, View Article : Google Scholar

9 

Cappelleri JC, Rosen RC, Smith MD, Mishra A and Osterloh IH: Diagnostic evaluation of the erectile function domain of the International Index of Erectile Function. Urology. 54:346–351. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Mulhall JP, Goldstein I, Bushmakin AG, Cappelleri JC and Hvidsten K: Validation of the erection hardness score. J Sex Med. 4:1626–1634. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Walsh PC: Anatomic radical prostatectomy: evolution of the surgical technique. J Urol. 160:2418–2424. 1998. View Article : Google Scholar : PubMed/NCBI

12 

Van Velthoven RF, Ahlering TE, Peltier A, Skarecky DW and Clayman RV: Technique for laparoscopic running urethrovesical anastomosis: the single knot method. Urology. 61:699–702. 2003.PubMed/NCBI

13 

Briganti A, Di Trapani E, Abdollah F, Gallina A, Suardi N, Capitanio U, Tutolo M, Passoni N, Salonia A, Digirolamo V, et al: Choosing the best candidates for penile rehabilitation after bilateral nerve-sparing radical prostatectomy. J Sex Med. 9:608–617. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Hwang TI, Tsai TF, Lin YC, Chiang HS and Chang LS: A survey of erectile dysfunction in Taiwan: use of the erection hardness score and quality of erection questionnaire. J Sex Med. 7:2817–2824. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Dindo D, Demartines N and Clavien PA: Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 240:205–213. 2004. View Article : Google Scholar

16 

Masterson TA, Cheng L, Boris RS and Koch MO: Open vs. robotic-assisted radical prostatectomy: A single surgeon and pathologist comparison of pathologic and oncologic outcomes. Urol Oncol. Jan 3–2012.(Epub ahead of print).

17 

Rocco B, Matei DV, Melegari S, Ospina JC, Mazzoleni F, Errico G, Mastropasqua M, Santoro L, Detti S and de Cobelli O: Robotic vs. open prostatectomy in a laparoscopically naive centre: a matched-pair analysis. BJU Int. 104:991–995. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Tewari K, Jhaveri J, Rao S, Yadav R, Bartsch G, Te A, Ioffe E, Pineda M, Mudaliar S, Nguyen L, et al: Total reconstruction of the vesico-urethral junction. BJU Int. 101:871–877. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Drouin SJ, Vaessen C, Misraï V, Ferhi K, Bitker MO, Chartier-Kastler E, Haertig A, Richard F and Rouprêt M: Oncologic and functional outcomes after robot-assisted laparoscopic radical prostatectomy. Prog Urol. 19:158–164. 2009.PubMed/NCBI

20 

Tsao AK, Smaldone MD, Averch TD and Jackman SV: Robot-assisted laparoscopic prostatectomy: the first 100 patients - improving patient safety and outcomes. J Endourol. 23:481–484. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Novara G, Ficarra V, D’Elia C, Secco S, De Gobbi A, Cavalleri S and Artibani W: Preoperative criteria to select patients for bilateral nerve-sparing robotic-assisted radical prostatectomy. J Sex Med. 7:839–845. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ludovico GM, Dachille G, Pagliarulo G, D'Elia C, Mondaini N, Gacci M, Detti B, Malossini G, Bartoletti R, Cai T, Cai T, et al: Bilateral nerve sparing robotic-assisted radical prostatectomy is associated with faster continence recovery but not with erectile function recovery compared with retropubic open prostatectomy: The need for accurate selection of patients. Oncol Rep 29: 2445-2450, 2013.
APA
Ludovico, G.M., Dachille, G., Pagliarulo, G., D'Elia, C., Mondaini, N., Gacci, M. ... Cai, T. (2013). Bilateral nerve sparing robotic-assisted radical prostatectomy is associated with faster continence recovery but not with erectile function recovery compared with retropubic open prostatectomy: The need for accurate selection of patients. Oncology Reports, 29, 2445-2450. https://doi.org/10.3892/or.2013.2365
MLA
Ludovico, G. M., Dachille, G., Pagliarulo, G., D'Elia, C., Mondaini, N., Gacci, M., Detti, B., Malossini, G., Bartoletti, R., Cai, T."Bilateral nerve sparing robotic-assisted radical prostatectomy is associated with faster continence recovery but not with erectile function recovery compared with retropubic open prostatectomy: The need for accurate selection of patients". Oncology Reports 29.6 (2013): 2445-2450.
Chicago
Ludovico, G. M., Dachille, G., Pagliarulo, G., D'Elia, C., Mondaini, N., Gacci, M., Detti, B., Malossini, G., Bartoletti, R., Cai, T."Bilateral nerve sparing robotic-assisted radical prostatectomy is associated with faster continence recovery but not with erectile function recovery compared with retropubic open prostatectomy: The need for accurate selection of patients". Oncology Reports 29, no. 6 (2013): 2445-2450. https://doi.org/10.3892/or.2013.2365
Copy and paste a formatted citation
x
Spandidos Publications style
Ludovico GM, Dachille G, Pagliarulo G, D'Elia C, Mondaini N, Gacci M, Detti B, Malossini G, Bartoletti R, Cai T, Cai T, et al: Bilateral nerve sparing robotic-assisted radical prostatectomy is associated with faster continence recovery but not with erectile function recovery compared with retropubic open prostatectomy: The need for accurate selection of patients. Oncol Rep 29: 2445-2450, 2013.
APA
Ludovico, G.M., Dachille, G., Pagliarulo, G., D'Elia, C., Mondaini, N., Gacci, M. ... Cai, T. (2013). Bilateral nerve sparing robotic-assisted radical prostatectomy is associated with faster continence recovery but not with erectile function recovery compared with retropubic open prostatectomy: The need for accurate selection of patients. Oncology Reports, 29, 2445-2450. https://doi.org/10.3892/or.2013.2365
MLA
Ludovico, G. M., Dachille, G., Pagliarulo, G., D'Elia, C., Mondaini, N., Gacci, M., Detti, B., Malossini, G., Bartoletti, R., Cai, T."Bilateral nerve sparing robotic-assisted radical prostatectomy is associated with faster continence recovery but not with erectile function recovery compared with retropubic open prostatectomy: The need for accurate selection of patients". Oncology Reports 29.6 (2013): 2445-2450.
Chicago
Ludovico, G. M., Dachille, G., Pagliarulo, G., D'Elia, C., Mondaini, N., Gacci, M., Detti, B., Malossini, G., Bartoletti, R., Cai, T."Bilateral nerve sparing robotic-assisted radical prostatectomy is associated with faster continence recovery but not with erectile function recovery compared with retropubic open prostatectomy: The need for accurate selection of patients". Oncology Reports 29, no. 6 (2013): 2445-2450. https://doi.org/10.3892/or.2013.2365
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team