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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2013 Volume 29 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

miR-205 promotes tumor proliferation and invasion through targeting ESRRG in endometrial carcinoma

  • Authors:
    • Ning Su
    • Haifeng Qiu
    • Yifei Chen
    • Tingting Yang
    • Qin Yan
    • Xiaoping Wan
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital of the China Welfare Institute Affiliated to Shanghai Jiao Tong University, Shanghai 200030, P.R. China, Central Laboratory, International Peace Maternity and Child Health Hospital of the China Welfare Institute Affiliated to Shanghai Jiao Tong University, Shanghai 200030, P.R. China
  • Pages: 2297-2302
    |
    Published online on: April 10, 2013
       https://doi.org/10.3892/or.2013.2400
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Abstract

Increasing evidence suggests that miR‑205 is frequently dysregulated in many types of human cancers, suggesting its important roles in the initiation and progression of cancer. However, the functions of miR‑205 in human endometrial endometrioid carcinoma (EEC) are still unknown. In this study, we investigated the expression of miR‑205 in both normal endometrium and EEC tissues using TaqMan PCR. Compared to normal tissues, miR‑205 was significantly upregulated in EEC (P<0.001). After transfection of miR‑205 inhibitors into Ishikawa cells (or transfection of miR‑205 mimics into AN3CA cells), we demonstrated that the cellular proliferation, migration and invasion properties were negatively regulated by miR‑205. Moreover, by combination of microRNA target prediction algorithms and luciferase reporter system, we identified estrogen-related receptor‑γ (ESRRG) as a target of miR‑205. In conclusion, we demonstrated frequent upregulation of miR‑205 in EEC. In gain‑of‑function and loss‑of‑function assays, inhibition of miR‑205 reduced cellular proliferation, migration and invasion; vice versa, increased levels of miR‑205 led to upregulated cellular proliferation, migration and invasion. Nonetheless, we identified the ESRRG gene to be a novel target, which could be helpful to elucidate mechanisms underlying the tumorigenesis of EEC.
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Copy and paste a formatted citation
Spandidos Publications style
Su N, Qiu H, Chen Y, Yang T, Yan Q and Wan X: miR-205 promotes tumor proliferation and invasion through targeting ESRRG in endometrial carcinoma. Oncol Rep 29: 2297-2302, 2013.
APA
Su, N., Qiu, H., Chen, Y., Yang, T., Yan, Q., & Wan, X. (2013). miR-205 promotes tumor proliferation and invasion through targeting ESRRG in endometrial carcinoma. Oncology Reports, 29, 2297-2302. https://doi.org/10.3892/or.2013.2400
MLA
Su, N., Qiu, H., Chen, Y., Yang, T., Yan, Q., Wan, X."miR-205 promotes tumor proliferation and invasion through targeting ESRRG in endometrial carcinoma". Oncology Reports 29.6 (2013): 2297-2302.
Chicago
Su, N., Qiu, H., Chen, Y., Yang, T., Yan, Q., Wan, X."miR-205 promotes tumor proliferation and invasion through targeting ESRRG in endometrial carcinoma". Oncology Reports 29, no. 6 (2013): 2297-2302. https://doi.org/10.3892/or.2013.2400
Copy and paste a formatted citation
x
Spandidos Publications style
Su N, Qiu H, Chen Y, Yang T, Yan Q and Wan X: miR-205 promotes tumor proliferation and invasion through targeting ESRRG in endometrial carcinoma. Oncol Rep 29: 2297-2302, 2013.
APA
Su, N., Qiu, H., Chen, Y., Yang, T., Yan, Q., & Wan, X. (2013). miR-205 promotes tumor proliferation and invasion through targeting ESRRG in endometrial carcinoma. Oncology Reports, 29, 2297-2302. https://doi.org/10.3892/or.2013.2400
MLA
Su, N., Qiu, H., Chen, Y., Yang, T., Yan, Q., Wan, X."miR-205 promotes tumor proliferation and invasion through targeting ESRRG in endometrial carcinoma". Oncology Reports 29.6 (2013): 2297-2302.
Chicago
Su, N., Qiu, H., Chen, Y., Yang, T., Yan, Q., Wan, X."miR-205 promotes tumor proliferation and invasion through targeting ESRRG in endometrial carcinoma". Oncology Reports 29, no. 6 (2013): 2297-2302. https://doi.org/10.3892/or.2013.2400
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