Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
July 2013 Volume 30 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July 2013 Volume 30 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Validity of bone marker measurements for monitoring response to bisphosphonate therapy with zoledronic acid in metastatic breast cancer

  • Authors:
    • Bahriye Aktas
    • Sabine Kasimir-Bauer
    • Nils Lehmann
    • Rainer Kimmig
    • Mitra Tewes
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, University of Duisburg-Essen, D-45122 Essen, Germany, IMIBE, Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, D-45122 Essen, Germany, Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, D-45122 Essen, Germany
  • Pages: 441-447
    |
    Published online on: April 22, 2013
       https://doi.org/10.3892/or.2013.2409
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Bone is the most common site of metastasis in breast cancer. Detection relies on imaging technology which is costly and can only be performed to a certain degree. Bone markers are non-invasive, inexpensive and may potentially serve as predictive and prognostic surrogate endpoints in detecting bone metastases and response to bisphosphonates. This study analyzed the value of the serum bone turnover markers PINP and ICTP for bone metastases in metastatic breast cancer patients receiving zoledronic acid. The results were compared with the serum levels of CEA and CA 15-3, and analyzed with respect to the number of bone metastases as well as clinical response. Forty patients with confirmed bone metastases who received chemotherapy and/or hormonal therapy and zoledronic acid i.v. q4 weeks participated in the present study. blood (5 ml) was collected at the start of the study and q3 months for a period of one year for the analysis of PINP, ICTP, CEA and CA 15-3 using radioimmunoassays and ELISA, respectively. Imaging of bone metastases was performed at the same time points. In 29 out of 40 patients, more than 3 bone metastases were confirmed by imaging and 11 out of 40 patients presented with 3 or less. At the start of the study, the median value for ICTP was 6 µg/l and for PINP 58.7 µg/l. At the end of the study the median values were 4.5 µg/l for ICTP and 21 µg/l for PINP. When patients were stratified into responders and non-responders, a decrease in both PINP (P<0.0001) and ICTP (P=0.048) was observed for the responders, while the level of ICTP (P=0.02) increased for the non-responders. Serum PINP and ICTP concentrations were significantly different when patients were stratified into groups of those having more than 3 bone metastases and 3 or less, respectively (P<0.05). CEA and CA 15-3 levels did not differ with respect to the number of bone metastases, while the tumor marker levels determined at the end of the study significantly distinguished responders from non-responders (P=0.002 and P=0.004). In conclusion, in contrast to serum tumor markers, the determination of PINP and ICTP allows inferences to the number of bone metastases and appears to be a useful tool for prediction and monitoring metastatic breast cancer patients undergoing bisphosphonate therapy with zoledronic acid for the treatment of bone metastases.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Plebani M, Bernardi D, Zanninotto M, De Paoli M, Secchiero S and Sciacovelli L: New and traditional serum markers of bone metabolism in the detection of skeletal metastases. Clin Biochem. 29:67–72. 1996. View Article : Google Scholar : PubMed/NCBI

2 

Rosenthal DI: Radiologic diagnosis of bone metastases. Cancer. 80:1595–1607. 1997. View Article : Google Scholar : PubMed/NCBI

3 

Jung K, Lein M, Stephan C, Von HK, Semjonow A and Sinha P: Comparison of 10 serum bone turnover markers in prostate carcinoma patients with bone metastatic spread: diagnostic and prognostic implications. Int J Cancer. 111:783–791. 2004. View Article : Google Scholar : PubMed/NCBI

4 

O’Sullivan JM and Cook GJ: A review of the efficacy of bone scanning in prostate and breast cancer. Q J Nucl Med. 46:152–159. 2002.PubMed/NCBI

5 

Costa L, Demers LM, Gouveia-Oliveira A, Schaller J, Costa EB, Moura MC and Lipton A: Prospective evaluation of the peptide-bound collagen type I cross-links N-telopeptide and C-telopeptide in predicting bone metastases status. J Clin Oncol. 20:850–856. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Lipton A, Costa L, Ali S and Demers L: Use of markers of bone turnover for monitoring bone metastases and the response to therapy. Semin Oncol. 28(4 Suppl 11): 54–59. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Green JR: Bisphosphonates: preclinical review. Oncologist. 9(Suppl 4): 3–13. 2004. View Article : Google Scholar

8 

Coleman RE: The clinical use of bone resorption markers in patients with malignant bone disease. Cancer. 94:2521–2533. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Roodman GD: Mechanisms of bone metastases. N Engl J Med. 350:1655–1664. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Rosen LS, Gordon D, Kaminski M, Howell A, Belch A, Mackey J, Apffelstaedt J, Hussein MA, Coleman RE, Reitsma DJ, Chen BL and Seaman JJ: Long-term efficacy and safety of zoledronic acid in the treatment of skeletal metastases in patients with non-small cell lung carcinoma and other solid tumors: a randomized, phase III, double-blind, placebo-controlled trial. Cancer. 98:1735–1744. 2003.PubMed/NCBI

11 

Saad F, Gleason D, Murray R, Tchekmedyian S, Venner P, Lacombe L, Chin J, Vinholes J, Goas A and Zheng M; for the Zoledronic Acid Prostate Cancer Study Group. Long-term efficacy of zoledronic acid for the prevention of skeletal complications in patients with metastatic hormone-refractory prostate cancer. J Natl Cancer Inst. 96:879–882. 2004. View Article : Google Scholar

12 

Pecherstorfer M, Zimmer-Roth I, Schilling T, Woitge HW, Schmidt H, Baumgartner G, et al: The diagnostic value of pyridinium cross-links of collagen, serum total alkaline phosphatase, and urinary calcium excretion in neoplastic bone disease. J Clin Endocrinol Metab. 80:97–103. 1995.

13 

Vogel CL, Schoenfelder J, Shemano I, Hayes DF and Gams RA: Worsening bone scan in the evaluation of antitumor response during hormonal therapy of breast cancer. J Clin Oncol. 13:1123–1128. 1995.PubMed/NCBI

14 

Pollen JF, Witztum KF and Ashburn WL: The flare phenomenon on radionuclide bone scan in metastatic prostate cancer. AJR Am J Roentgenol. 142:773–776. 1984. View Article : Google Scholar : PubMed/NCBI

15 

Huang Q and Ouyang X: Biochemical-markers for the diagnosis of bone metastasis: a clinical review. Cancer Epidemiol. 6:94–98. 2011.

16 

Seibel MJ: Clinical use of markers of bone turnover in metastatic bone disease. Nat Clin Pract Oncol. 2:504–517. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Coleman R, Brown J, Terpos E, Lipton A, Smith MR, Cook R and Major P: Bone markers and their prognostic value in metastatic bone disease: clinical evidence and future directions. Cancer Treat Rev. 34:629–639. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Seibel MJ: The use of molecular markers of bone turnover in the management of patients with metastatic bone disease. Clin Endocrinol. 68:839–849. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Cremers S and Garnero P: Biochemical markers of bone turnover in the clinical development of drugs for osteoporosis and metastatic bone disease: potential uses and pitfalls. Drugs. 66:2031–2058. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Brown JE, Cook RJ, Major P, Lipton A, Saad F, Smith M, Lee KA, Zheng M, Hei YJ and Colemann RE: Bone turnover markers as predictors of skeletal complications in prostate cancer, lung cancer, and other solid tumors. J Natl Cancer Inst. 97:59–69. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Pollmann D, Siepmann S, Geppert R, Wernecke KD, Possinger K and Lüftner D: The amino-terminal propeptide (PINP) of type I collagen is a clinically valid indicator of bone turnover and extent of metastatic spread in osseous metastatic breast cancer. Anticancer Res. 27:1853–1862. 2007.PubMed/NCBI

22 

Costa L, Demers LM, Speicher T, Gouveia Curley E, Harvey H, et al: Biochemical markers of bone turnover correlate with the extent of metastatic bone disease. In: American Society of Clinical Oncology 35th Annual Meeting; Philadelphia. 1999

23 

Berruti A, Dogliotti L, Gorzegno G, Torta M, Tampellini M, Tucci M, Cerutti S, Frezet MM, Stivanello M, Sacchetto G and Angeli A: Differential patterns of bone turnover in relation to bone pain and disease extent in bone in cancer patients with skeletal metastases. Clin Chem. 45:1240–1247. 1999.PubMed/NCBI

24 

Demers LM: Biochemical markers in the management of patients with metastatic bone disease. Clin Chem. 45:1131–1132. 1999.PubMed/NCBI

25 

Ikeda I, Miura T and Kondo I: Pyridinium cross-links as urinary markers of bone metastases in patients with prostate cancer. Br J Urol. 77:102–106. 1996. View Article : Google Scholar : PubMed/NCBI

26 

Costa L, Demers LM, Gouveia A, Schalla J, Costa EB, Demoura MC and Lipton A: Correlation of urinary N-telopeptide levels with progression of bone metastases: a prospective study (Abstract 12). Cancer. 88(Suppl): 30942000.

27 

Zafeirakis A: Collagenous and non-collagenous biochemical markers of bone metastases from prostate cancer. Hippokratia. 14:164–169. 2010.PubMed/NCBI

28 

Lipton A, Cook R, Saad F, Major P, Garnero P, Terpos E, Brown JE and Coleman RE: Normalization of bone markers is associated with improved survival and elevated bone resorption receiving zoledronic acid. Cancer. 113:193–201. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Pons-Anicet DMF, Krebs BP, Mira R and Namer M: Value of CA 15:3 in the follow-up of breast cancer patients. Br J Cancer. 55:567–569. 1987. View Article : Google Scholar : PubMed/NCBI

30 

Yildiz M, Oral B, Bozkurt M and Cobaner A: Relationship between bone scintigraphy and tumor markers in patients with breast cancer. Ann Nucl Med. 18:501–505. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Buamah PK, Bent DJ, Bodger WAH and Skillen AW: A profile of serum CA 15-3, carcinoembryonic antigen, alkaline phosphatase, and γ-glutamyl transferase levels in patients with breast cancer. J Surg Oncol. 53:84–87. 1993.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Aktas B, Kasimir-Bauer S, Lehmann N, Kimmig R and Tewes M: Validity of bone marker measurements for monitoring response to bisphosphonate therapy with zoledronic acid in metastatic breast cancer. Oncol Rep 30: 441-447, 2013.
APA
Aktas, B., Kasimir-Bauer, S., Lehmann, N., Kimmig, R., & Tewes, M. (2013). Validity of bone marker measurements for monitoring response to bisphosphonate therapy with zoledronic acid in metastatic breast cancer. Oncology Reports, 30, 441-447. https://doi.org/10.3892/or.2013.2409
MLA
Aktas, B., Kasimir-Bauer, S., Lehmann, N., Kimmig, R., Tewes, M."Validity of bone marker measurements for monitoring response to bisphosphonate therapy with zoledronic acid in metastatic breast cancer". Oncology Reports 30.1 (2013): 441-447.
Chicago
Aktas, B., Kasimir-Bauer, S., Lehmann, N., Kimmig, R., Tewes, M."Validity of bone marker measurements for monitoring response to bisphosphonate therapy with zoledronic acid in metastatic breast cancer". Oncology Reports 30, no. 1 (2013): 441-447. https://doi.org/10.3892/or.2013.2409
Copy and paste a formatted citation
x
Spandidos Publications style
Aktas B, Kasimir-Bauer S, Lehmann N, Kimmig R and Tewes M: Validity of bone marker measurements for monitoring response to bisphosphonate therapy with zoledronic acid in metastatic breast cancer. Oncol Rep 30: 441-447, 2013.
APA
Aktas, B., Kasimir-Bauer, S., Lehmann, N., Kimmig, R., & Tewes, M. (2013). Validity of bone marker measurements for monitoring response to bisphosphonate therapy with zoledronic acid in metastatic breast cancer. Oncology Reports, 30, 441-447. https://doi.org/10.3892/or.2013.2409
MLA
Aktas, B., Kasimir-Bauer, S., Lehmann, N., Kimmig, R., Tewes, M."Validity of bone marker measurements for monitoring response to bisphosphonate therapy with zoledronic acid in metastatic breast cancer". Oncology Reports 30.1 (2013): 441-447.
Chicago
Aktas, B., Kasimir-Bauer, S., Lehmann, N., Kimmig, R., Tewes, M."Validity of bone marker measurements for monitoring response to bisphosphonate therapy with zoledronic acid in metastatic breast cancer". Oncology Reports 30, no. 1 (2013): 441-447. https://doi.org/10.3892/or.2013.2409
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team