|
1
|
Jemal A, Bray F, Center MM, Ferlay J, Ward
E and Forman D: Global cancer statistics. CA Cancer J Clin.
61:69–90. 2011. View Article : Google Scholar
|
|
2
|
Michaud DS, Spiegelman D, Clinton SK, Rimm
EB, Willett WC and Giovannucci EL: Fruit and vegetable intake and
incidence of bladder cancer in a male prospective cohort. J Natl
Cancer Inst. 91:605–613. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Annema N, Heyworth JS, McNaughton SA,
Iacopetta B and Fritschi L: Fruit and vegetable consumption and the
risk of proximal colon, distal colon, and rectal cancers in a
case-control study in Western Australia. J Am Diet Assoc.
111:1479–1490. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Larsson SC, Hakansson N, Näslund I,
Bergkvist L and Wolk A: Fruit and vegetable consumption in relation
to pancreatic cancer risk: a prospective study. Cancer Epidemiol
Biomarkers Prev. 15:301–305. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
van Poppel G, Verhoeven DT, Verhagen H and
Goldbohm RA: Brassica vegetables and cancer prevention.
Epidemiology and mechanisms. Adv Exp Med Biol. 472:159–168.
1999.
|
|
6
|
Keck AS and Finley JW: Cruciferous
vegetables: cancer protective mechanisms of glucosinolate
hydrolysis products and selenium. Integr Cancer Ther. 3:5–12. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Shertzer H and Senft A: The micronutrient
indole-3-carbinol: implications for disease and chemoprevention.
Drug Metabol Drug Interact. 14:159–188. 2011.PubMed/NCBI
|
|
8
|
Chinni SR, Li Y, Upadhyay S, Koppolu PK
and Sarkar FH: Indole-3-carbinol (I3C) induced cell growth
inhibition, G1 cell cycle arrest and apoptosis in prostate cancer
cells. Oncogene. 20:2927–2936. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Brew CT, Aronchik I, Hsu JC, et al:
Indole-3-carbinol activates the ATM signaling pathway independent
of DNA damage to stabilize p53 and induce G1 arrest of human
mammary epithelial cells. Int J Cancer. 118:857–868. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Rahman KM, Aranha O and Sarkar FH:
Indole-3-carbinol (I3C) induces apoptosis in tumorigenic but not in
nontumorigenic breast epithelial cells. Nutr Cancer. 45:101–112.
2003. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Meng Q, Qi M, Chen DZ, et al: Suppression
of breast cancer invasion and migration by indole-3-carbinol:
associated with up-regulation of BRCA1 and E-cadherin/catenin
complexes. J Mol Med. 78:155–165. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Aggarwal BB and Ichikawa H: Molecular
targets and anticancer potential of indole-3-carbinol and its
derivatives. Cell Cycle. 4:1201–1215. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Chang F, Lee JT, Navolanic PM, et al:
Involvement of PI3K/Akt pathway in cell cycle progression,
apoptosis, and neoplastic transformation: a target for cancer
chemotherapy. Leukemia. 17:590–603. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Fresno Vara JA, Casado E, de Castro J,
Cejas P, Belda-Iniesta C and González-Barón M: PI3K/Akt signalling
pathway and cancer. Cancer Treat Rev. 30:193–204. 2004.PubMed/NCBI
|
|
15
|
Watanabe S, Sato K, Okazaki Y, Tonogi M,
Tanaka Y and Yamane GY: Activation of PI3K-AKT pathway in oral
epithelial dysplasia and early cancer of tongue. Bull Tokyo Dent
Coll. 50:125–133. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Oganesian A, Hendricks JD and Williams DE:
Long term dietary indole-3-carbinol inhibits
diethylnitrosamine-initiated hepatocarcinogenesis in the infant
mouse model. Cancer Lett. 118:87–94. 1997. View Article : Google Scholar
|
|
17
|
Plate AY and Gallaher DD: Effects of
indole-3-carbinol and phenethyl isothiocyanate on colon
carcinogenesis induced by azoxymethane in rats. Carcinogenesis.
27:287–292. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Pappa G, Lichtenberg M, Iori R, Barillari
J, Bartsch H and Gerhäuser C: Comparison of growth inhibition
profiles and mechanisms of apoptosis induction in human colon
cancer cell lines by isothiocyanates and indoles from
Brassicaceae. Mutat Res. 599:76–87. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Brognard J, Clark AS, Ni Y and Dennis PA:
Akt/protein kinase B is constitutively active in non-small cell
lung cancer cells and promotes cellular survival and resistance to
chemotherapy and radiation. Cancer Res. 61:3986–3997.
2001.PubMed/NCBI
|
|
20
|
Cicenas J: The potential role of Akt
phosphorylation in human cancers. Int J Biol Markers. 23:1–9.
2008.PubMed/NCBI
|
|
21
|
Rahman KM, Li Y and Sarkar FH:
Inactivation of akt and NF-κB play important roles during
indole-3-carbinol-induced apoptosis in breast cancer cells. Nutr
Cancer. 48:84–94. 2004.
|
|
22
|
Chen DZ, Qi M, Auborn KJ and Carter TH:
Indole-3-carbinol and diindolylmethane induce apoptosis of human
cervical cancer cells and in murine HPV16-transgenic preneoplastic
cervical epithelium. J Nutr. 131:3294–3302. 2001.
|
|
23
|
Wu TY, Saw CL, Khor TO, Pung D,
Boyanapalli SS and Kong AN: In vivo pharmacodynamics of
indole-3-carbinol in the inhibition of prostate cancer in
transgenic adenocarcinoma of mouse prostate (TRAMP) mice:
involvement of Nrf2 and cell cycle/apoptosis signaling pathways.
Mol Carcinog. 51:761–770. 2012. View
Article : Google Scholar : PubMed/NCBI
|
|
24
|
Newfield L, Goldsmith A, Bradlow HL and
Auborn K: Estrogen metabolism and human papillomavirus-induced
tumors of the larynx: chemo-prophylaxis with indole-3-carbinol.
Anticancer Res. 13:337–341. 1993.PubMed/NCBI
|
