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Article

Human papillomavirus predicts the outcome following concomitant chemoradiotherapy in patients with head and neck squamous cell carcinomas

  • Authors:
    • Anaëlle Duray
    • Géraldine Descamps
    • Christine Decaestecker
    • Nicolas Sirtaine
    • André Gilles
    • Mohamad Khalifé
    • Gilbert Chantrain
    • Christophe E. Depuydt
    • Philippe Delvenne
    • Sven Saussez
  • View Affiliations / Copyright

    Affiliations: Laboratory of Anatomy, Faculty of Medicine and Pharmacy, University of Mons, Mons, Belgium, Laboratory of Toxicology, Institute of Pharmacy, Free University of Brussels, Brussels, Belgium, Department of Pathology, Faculty of Medicine, Institut Bordet, Free University of Brussels, Brussels, Belgium, Department of Pathology, RHMS Baudour, Mons, Belgium, Department of Oto-Rhino-Laryngology, CHU Saint-Pierre, Free University of Brussels, Brussels, Belgium, Laboratory for Clinical Pathology and Molecular Biology (LaboLokeren, Campus Riatol), Antwerp, Belgium, Department of Pathology, CHU Sart-Tilman, University of Liège, Liège, Belgium
  • Pages: 371-376
    |
    Published online on: April 22, 2013
       https://doi.org/10.3892/or.2013.2415
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Abstract

We investigated the prevalence of human papillomavirus (HPV) in a clinical series of 72 patients with head and neck squamous cell carcinoma (HNSCC) using a retrospective and prospective study design. The majority of patients were smokers and/or drinkers and were treated with concomitant chemoradiotherapy (CCR). Furthermore, we assessed the impact of HPV positivity on the response to CCR. Paraffin-embedded samples from HNSCC patients (n=72) were evaluated for the presence of HPV DNA using both GP5+/GP6+ consensus PCR and type-specific E6/E7 PCR to detect HPV types 6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 67 and 68. The type-specific E6/E7 PCR demonstrated that 20 out of 69 HNSCC patients (29%) presented with high-risk (HR) HPV types and that 5 of the 69 HNSCC patients (7%) presented with low-risk (LR) HPV types. Using the GP5+/GP6+ PCR, we observed that the rate of response was statistically lower in the HPV+ group (P=0.02). Concerning patient outcomes in terms of recurrence and survival, we observed that the prognosis was poorer for HPV+ patients. We showed for the first time that patients with HPV+ HNSCC present with a worse prognosis after CCR. This observation highlights the need for prospective studies with large numbers of patients and a detailed history of tobacco and alcohol consumption before validating HPV as a marker of prognosis following CCR.
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Copy and paste a formatted citation
Spandidos Publications style
Duray A, Descamps G, Decaestecker C, Sirtaine N, Gilles A, Khalifé M, Chantrain G, Depuydt CE, Delvenne P, Saussez S, Saussez S, et al: Human papillomavirus predicts the outcome following concomitant chemoradiotherapy in patients with head and neck squamous cell carcinomas. Oncol Rep 30: 371-376, 2013.
APA
Duray, A., Descamps, G., Decaestecker, C., Sirtaine, N., Gilles, A., Khalifé, M. ... Saussez, S. (2013). Human papillomavirus predicts the outcome following concomitant chemoradiotherapy in patients with head and neck squamous cell carcinomas. Oncology Reports, 30, 371-376. https://doi.org/10.3892/or.2013.2415
MLA
Duray, A., Descamps, G., Decaestecker, C., Sirtaine, N., Gilles, A., Khalifé, M., Chantrain, G., Depuydt, C. E., Delvenne, P., Saussez, S."Human papillomavirus predicts the outcome following concomitant chemoradiotherapy in patients with head and neck squamous cell carcinomas". Oncology Reports 30.1 (2013): 371-376.
Chicago
Duray, A., Descamps, G., Decaestecker, C., Sirtaine, N., Gilles, A., Khalifé, M., Chantrain, G., Depuydt, C. E., Delvenne, P., Saussez, S."Human papillomavirus predicts the outcome following concomitant chemoradiotherapy in patients with head and neck squamous cell carcinomas". Oncology Reports 30, no. 1 (2013): 371-376. https://doi.org/10.3892/or.2013.2415
Copy and paste a formatted citation
x
Spandidos Publications style
Duray A, Descamps G, Decaestecker C, Sirtaine N, Gilles A, Khalifé M, Chantrain G, Depuydt CE, Delvenne P, Saussez S, Saussez S, et al: Human papillomavirus predicts the outcome following concomitant chemoradiotherapy in patients with head and neck squamous cell carcinomas. Oncol Rep 30: 371-376, 2013.
APA
Duray, A., Descamps, G., Decaestecker, C., Sirtaine, N., Gilles, A., Khalifé, M. ... Saussez, S. (2013). Human papillomavirus predicts the outcome following concomitant chemoradiotherapy in patients with head and neck squamous cell carcinomas. Oncology Reports, 30, 371-376. https://doi.org/10.3892/or.2013.2415
MLA
Duray, A., Descamps, G., Decaestecker, C., Sirtaine, N., Gilles, A., Khalifé, M., Chantrain, G., Depuydt, C. E., Delvenne, P., Saussez, S."Human papillomavirus predicts the outcome following concomitant chemoradiotherapy in patients with head and neck squamous cell carcinomas". Oncology Reports 30.1 (2013): 371-376.
Chicago
Duray, A., Descamps, G., Decaestecker, C., Sirtaine, N., Gilles, A., Khalifé, M., Chantrain, G., Depuydt, C. E., Delvenne, P., Saussez, S."Human papillomavirus predicts the outcome following concomitant chemoradiotherapy in patients with head and neck squamous cell carcinomas". Oncology Reports 30, no. 1 (2013): 371-376. https://doi.org/10.3892/or.2013.2415
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