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Article

Investigation of the clinicopathological features of fallopian tube malignancy

  • Authors:
    • Yoshihito Yokoyama
    • Masayuki Futagami
    • Toshio Fujimoto
    • Yukihiro Terada
    • Eriko  Takatori
    • Toru Sugiyama
    • Takeo Otsuki
    • Nobuo Yaegashi
    • Takanobu Kojimahara
    • Hirohisa Kurachi
    • Hiroshi Nishiyama
    • Keiya Fujimori
    • Toru Tase
    • Hideki Mizunuma
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, Hirosaki 036‑8562, Japan, Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita 010-8543, Japan, Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Morioka 020-8505, Japan, Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Aoba-ku, Sendai 980‑8574, Japan, Department of Obstetrics and Gynecology, Yamagata University School of Medicine, Yamagata 990‑9585, Japan, Department of Obstetrics and Gynecology, School of Medicine, Fukushima Medical University, Fukushima 960‑1295, Japan, Department of Gynecology, Miyagi Cancer Center, Natori 981-1293, Japan
  • Pages: 79-84
    |
    Published online on: April 30, 2013
       https://doi.org/10.3892/or.2013.2439
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Abstract

The present study investigated the clinico­pathological features of fallopian tube malignancy (FTM) and elucidated the biological behavior of this disorder. Data were compiled concerning FTM from 68 patients from 7 institutes. The patients included 60 cases with fallopian tube carcinoma and 8 cases with fallopian tube carcinosarcoma. The clinical stage was stage III or higher in 72% of the cases. A complete response or partial response was achieved in 56 and 10 of the 68 patients with FTM, respectively, indicating a response rate of 97.1%. The median observation period for FTM was 41 months (3 to 126 months). Three of the 19 patients with stage I/II disease (16%) and 31 of the 49 patients with stage III/IV disease (63%) experienced recurrence, with a median progression-free survival of 17.5 months, and a 3-year overall survival of 77.2%. Regarding the site of recurrence, local intraperitoneal recurrence (26.2%) and solitary recurrences in lymph nodes (19.0%) and in the liver (16.7%) were relatively frequent. Secondary debulking surgery (SDS) was performed in 15 patients (44%) out of the 34 recurrent FTMs. Conversely, recurrence was associated with ascites (carcinomatous peritonitis) in 4 of the 34 recurrent patients, but all 4 patients died. The median survival period after recurrence was 28 months: 7.5 and 30 months with and without ascites, respectively (P<0.001). A univariate analysis showed that prognosis was significantly correlated only with whether SDS could be performed. These results suggest that since FTM frequently results in solitary recurrence, aggressive recurrence treatment including SDS could improve prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Yokoyama Y, Futagami M, Fujimoto T, Terada Y, Takatori E, Sugiyama T, Otsuki T, Yaegashi N, Kojimahara T, Kurachi H, Kurachi H, et al: Investigation of the clinicopathological features of fallopian tube malignancy. Oncol Rep 30: 79-84, 2013.
APA
Yokoyama, Y., Futagami, M., Fujimoto, T., Terada, Y., Takatori, E., Sugiyama, T. ... Mizunuma, H. (2013). Investigation of the clinicopathological features of fallopian tube malignancy. Oncology Reports, 30, 79-84. https://doi.org/10.3892/or.2013.2439
MLA
Yokoyama, Y., Futagami, M., Fujimoto, T., Terada, Y., Takatori, E., Sugiyama, T., Otsuki, T., Yaegashi, N., Kojimahara, T., Kurachi, H., Nishiyama, H., Fujimori, K., Tase, T., Mizunuma, H."Investigation of the clinicopathological features of fallopian tube malignancy". Oncology Reports 30.1 (2013): 79-84.
Chicago
Yokoyama, Y., Futagami, M., Fujimoto, T., Terada, Y., Takatori, E., Sugiyama, T., Otsuki, T., Yaegashi, N., Kojimahara, T., Kurachi, H., Nishiyama, H., Fujimori, K., Tase, T., Mizunuma, H."Investigation of the clinicopathological features of fallopian tube malignancy". Oncology Reports 30, no. 1 (2013): 79-84. https://doi.org/10.3892/or.2013.2439
Copy and paste a formatted citation
x
Spandidos Publications style
Yokoyama Y, Futagami M, Fujimoto T, Terada Y, Takatori E, Sugiyama T, Otsuki T, Yaegashi N, Kojimahara T, Kurachi H, Kurachi H, et al: Investigation of the clinicopathological features of fallopian tube malignancy. Oncol Rep 30: 79-84, 2013.
APA
Yokoyama, Y., Futagami, M., Fujimoto, T., Terada, Y., Takatori, E., Sugiyama, T. ... Mizunuma, H. (2013). Investigation of the clinicopathological features of fallopian tube malignancy. Oncology Reports, 30, 79-84. https://doi.org/10.3892/or.2013.2439
MLA
Yokoyama, Y., Futagami, M., Fujimoto, T., Terada, Y., Takatori, E., Sugiyama, T., Otsuki, T., Yaegashi, N., Kojimahara, T., Kurachi, H., Nishiyama, H., Fujimori, K., Tase, T., Mizunuma, H."Investigation of the clinicopathological features of fallopian tube malignancy". Oncology Reports 30.1 (2013): 79-84.
Chicago
Yokoyama, Y., Futagami, M., Fujimoto, T., Terada, Y., Takatori, E., Sugiyama, T., Otsuki, T., Yaegashi, N., Kojimahara, T., Kurachi, H., Nishiyama, H., Fujimori, K., Tase, T., Mizunuma, H."Investigation of the clinicopathological features of fallopian tube malignancy". Oncology Reports 30, no. 1 (2013): 79-84. https://doi.org/10.3892/or.2013.2439
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