Search for mutations in signaling pathways in head and neck squamous cell carcinoma

  • Authors:
    • Thais Gulim De Carvalho
    • Ana Carolina De Carvalho
    • Danielle Calheiros Campelo Maia
    • Juliana Kaori Ogawa
    • Andre Lopes Carvalho
    • Andre Luiz Vettore
  • View Affiliations

  • Published online on: May 13, 2013     https://doi.org/10.3892/or.2013.2455
  • Pages: 334-340
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Abstract

Mutations in JAK-STAT signaling pathway genes have been associated with the development of various hematological tumors, but have not been investigated in head and neck tumors, and the PIK3CA, BRAF and KRAS genes have been described in a few cases of head and neck squamous cell carcinoma (HNSCC). In the present study, we determined the mutation status in members of the MAPK, PI3K-AKT and JAK-STAT pathways in HNSCC. Mutations in the KRAS, BRAF, PIK3CA, JAK1 and JAK2 genes were evaluated in 94 HNSCCs by direct DNA sequencing analysis using cDNA synthesized from RNA extracted from patient tumor cells. All patients evaluated had wild-type KRAS, BRAF and PIK3CA genes. Furthermore, although some known polymorphisms have been found in JAK1 genes (rs45598436, rs17127063, rs2230587, rs3737139, rs2230588 and rs12129819) and JAK2 (rs10429491, rs2230723, rs2230724 and rs41316003), no mutation could be detected. Our data indicate that mutations in these kinase genes seem to be rare events in HNSCC.
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July 2013
Volume 30 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
De Carvalho TG, De Carvalho AC, Maia DC, Ogawa JK, Carvalho AL and Vettore AL: Search for mutations in signaling pathways in head and neck squamous cell carcinoma. Oncol Rep 30: 334-340, 2013
APA
De Carvalho, T.G., De Carvalho, A.C., Maia, D.C., Ogawa, J.K., Carvalho, A.L., & Vettore, A.L. (2013). Search for mutations in signaling pathways in head and neck squamous cell carcinoma. Oncology Reports, 30, 334-340. https://doi.org/10.3892/or.2013.2455
MLA
De Carvalho, T. G., De Carvalho, A. C., Maia, D. C., Ogawa, J. K., Carvalho, A. L., Vettore, A. L."Search for mutations in signaling pathways in head and neck squamous cell carcinoma". Oncology Reports 30.1 (2013): 334-340.
Chicago
De Carvalho, T. G., De Carvalho, A. C., Maia, D. C., Ogawa, J. K., Carvalho, A. L., Vettore, A. L."Search for mutations in signaling pathways in head and neck squamous cell carcinoma". Oncology Reports 30, no. 1 (2013): 334-340. https://doi.org/10.3892/or.2013.2455