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Article

The in vitro antitumor activity of Siegesbeckia glabrescens against ovarian cancer through suppression of receptor tyrosine kinase expression and the signaling pathways

  • Authors:
    • Young-Rak Cho
    • Shin Wook Choi
    • Dong-Wan Seo
  • View Affiliations / Copyright

    Affiliations: College of Pharmacy, Dankook University, Cheonan 330-714, Republic of Korea, Radiant Research Institute, Radiant Inc., Chuncheon 200-883, Republic of Korea
  • Pages: 221-226
    |
    Published online on: May 15, 2013
       https://doi.org/10.3892/or.2013.2468
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Abstract

Siegesbeckia glabrescens (SG) Makino (Compositae) has been used as a traditional medicine for the treatment of a variety of diseases such as allergy, inflammation, acute hepatitis and hypertension. The primary aim of this study was to determine whether the ethanol extract of SG has antitumor activity against ovarian cancer and to identify molecular mechanisms and targets involved in the regulation of cell growth and progression. We demonstrate that SG treatment inhibits proliferation, adhesion, migration and invasion of SKOV-3 human ovarian cancer cells. The anti-proliferative effect of SG on SKOV-3 cells is accompanied by reduced expression of cyclin E and enhanced expression of the cyclin-dependent kinase inhibitor p27Kip1, leading to inhibition of pRb phosphorylation. We also show that these antitumor activities are found to be mediated through suppression of FAK, ERK, Akt and p70S6K-dependent signaling pathways and downregulation of receptor tyrosine kinases such as EGFR, VEGFR-2 and FGFR-1 as well as the cell adhesion molecule N-cadherin. Taken together, our findings suggest further development and evaluation of SG for the treatment of ovarian cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Cho Y, Choi SW and Seo D: The in vitro antitumor activity of Siegesbeckia glabrescens against ovarian cancer through suppression of receptor tyrosine kinase expression and the signaling pathways. Oncol Rep 30: 221-226, 2013.
APA
Cho, Y., Choi, S.W., & Seo, D. (2013). The in vitro antitumor activity of Siegesbeckia glabrescens against ovarian cancer through suppression of receptor tyrosine kinase expression and the signaling pathways. Oncology Reports, 30, 221-226. https://doi.org/10.3892/or.2013.2468
MLA
Cho, Y., Choi, S. W., Seo, D."The in vitro antitumor activity of Siegesbeckia glabrescens against ovarian cancer through suppression of receptor tyrosine kinase expression and the signaling pathways". Oncology Reports 30.1 (2013): 221-226.
Chicago
Cho, Y., Choi, S. W., Seo, D."The in vitro antitumor activity of Siegesbeckia glabrescens against ovarian cancer through suppression of receptor tyrosine kinase expression and the signaling pathways". Oncology Reports 30, no. 1 (2013): 221-226. https://doi.org/10.3892/or.2013.2468
Copy and paste a formatted citation
x
Spandidos Publications style
Cho Y, Choi SW and Seo D: The in vitro antitumor activity of Siegesbeckia glabrescens against ovarian cancer through suppression of receptor tyrosine kinase expression and the signaling pathways. Oncol Rep 30: 221-226, 2013.
APA
Cho, Y., Choi, S.W., & Seo, D. (2013). The in vitro antitumor activity of Siegesbeckia glabrescens against ovarian cancer through suppression of receptor tyrosine kinase expression and the signaling pathways. Oncology Reports, 30, 221-226. https://doi.org/10.3892/or.2013.2468
MLA
Cho, Y., Choi, S. W., Seo, D."The in vitro antitumor activity of Siegesbeckia glabrescens against ovarian cancer through suppression of receptor tyrosine kinase expression and the signaling pathways". Oncology Reports 30.1 (2013): 221-226.
Chicago
Cho, Y., Choi, S. W., Seo, D."The in vitro antitumor activity of Siegesbeckia glabrescens against ovarian cancer through suppression of receptor tyrosine kinase expression and the signaling pathways". Oncology Reports 30, no. 1 (2013): 221-226. https://doi.org/10.3892/or.2013.2468
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