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Article

Spontaneous clearance of Helicobacter pylori after pylorus-preserving gastrectomy for gastric cancer

  • Authors:
    • Tomoharu Miyashita
    • Koichi Miwa
    • Masafumi Inokuchi
    • Hisatoshi Nakagawara
    • Hidehiro Tajima
    • Hiroyuki Takamura
    • Itasu Ninomiya
    • Hirohisa Kitagawa
    • Sachio Fushida
    • Takashi Fujimura
    • Takanori Hattori
    • Tetsuo Ohta
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterologic Surgery, Kanazawa University Hospital, Kanazawa, Ishikawa 920-8641, Japan, Houju Memorial Hospital, Nomi, Ishikawa 923-1226, Japan, Department of Pathology, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan
  • Pages: 299-303
    |
    Published online on: May 15, 2013
       https://doi.org/10.3892/or.2013.2472
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Abstract

Residual mucosa in the gastric stump after pylorus-preserving gastrectomy (PPG) is considered a risk factor for the development of gastric stump carcinoma (GSC). Duodenogastric reflux (DGR) and Helicobacter pylori (H. pylori) infection are suspected to contribute to the development of GSC. The aim of this study was to investigate the prevalence of H. pylori in the residual stomach after PPG for gastric cancer and to assess factors associated with the presence of H. pylori. We investigated 72 patients who had undergone PPG at least 1 year prior to the study and were confirmed to be positive for H. pylori infection on presurgical endoscopic biopsy. The extent of DGR, the prevalence of H. pylori infection based on H. pylori stool antigen (HpSA) tests and the severity of gastritis were analyzed in these post-PPG patients. None of the patients had DGR, as shown by 99mTc-PMT. Of the 72 post-PPG patients, 33 (46%) were positive for HpSA. The prevalence of H. pylori infection was significantly lower after surgery than before surgery. The endoscopic severity of remnant gastritis, as well as histological inflammation and activity, were higher in H. pylori-positive patients than in H. pylori-negative patients. In conclusion, some patients who undergo PPG and are negative for DGR experience spontaneous clearance of H. pylori infection.
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1 

Sinning C, Schaefer N, Standop J, Hirner A and Wolff M: Gastric stump carcinoma - epidemiology and current concepts in pathogenesis and treatment. Eur J Surg Oncol. 33:133–139. 2007. View Article : Google Scholar : PubMed/NCBI

2 

van Rees BP, Saukkonen K, Ristimäki A, et al: Cyclooxygenase-2 expression during carcinogenesis in the human stomach. J Pathol. 196:171–179. 2002.PubMed/NCBI

3 

Sitarz R, Maciejewski R, Polkowski WP and Offerhaus GJ: Gastroenterostoma after Billroth antrectomy as a premalignant condition. World J Gastroenterol. 18:3201–3206. 2012.PubMed/NCBI

4 

Zur Hausen A, van Rees BP, van Beek J, et al: Epstein-Barr virus in gastric carcinomas and gastric stump carcinomas: a late event in gastric carcinogenesis. J Clin Pathol. 57:487–491. 2004.PubMed/NCBI

5 

Johannesson KA, Hammar E and Staël von Holstein C: Mucosal changes in the gastric remnant: long-term effects of bile reflux diversion and Helicobacter pylori infection. Eur J Gastroenterol Hepatol. 15:35–40. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Lagergren J, Lindam A and Mason RM: Gastric stump cancer after distal gastrectomy for benign gastric ulcer in a population-based study. Int J Cancer. 131:E1048–E1052. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Sowa M, Onoda N, Nakanishi I, et al: Early stage carcinoma of the gastric remnant in Japan. Anticancer Res. 13:1835–1838. 1993.PubMed/NCBI

8 

Kaminishi M, Shimizu N, Yamaguchi H, Hashimoto M, Sakai S and Oohara T: Different carcinogenesis in the gastric remnant after gastrectomy for gastric cancer. Cancer. 77:1646–1653. 1996. View Article : Google Scholar : PubMed/NCBI

9 

Ohashi M, Katai H, Fukagawa T, Gotoda T, Sano T and Sasako M: Cancer of the gastric stump following distal gastrectomy for cancer. Br J Surg. 94:92–95. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Kaneko K, Kondo H, Saito D, et al: Early gastric stump cancer following distal gastrectomy. Gut. 43:342–344. 1998. View Article : Google Scholar : PubMed/NCBI

11 

Thorban S, Böttcher K, Etter M, Roder JD, Busch R and Siewert JR: Prognostic factors in gastric stump carcinoma. Ann Surg. 231:188–194. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Lorusso D, Linsalata M, Pezzolla F, et al: Duodenogastric reflux and gastric mucosal polyamines in the non-operated stomach and in the gastric remnant after Billroth II gastric resection. A role in gastric carcinogenesis? Anticancer Res. 20:2197–2201. 2000.

13 

Goodwin CS, Armstrong JA and Marshall BJ: Campylobacter pyloridis, gastritis, and peptic ulceration. J Clin Pathol. 39:353–365. 1986. View Article : Google Scholar

14 

Matsumoto Y, Marusawa H, Kinoshita K, et al: Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium. Nat Med. 13:470–476. 2007. View Article : Google Scholar

15 

Takahashi S: Long-term Helicobacter pylori infection and the development of atrophic gastritis and gastric cancer in Japan. J Gastroenterol. 37(Suppl 13): 24–27. 2002.

16 

Uemura N and Okamoto S: Effect of Helicobacter pylori eradication on subsequent development of cancer after endoscopic resection of early gastric cancer in Japan. Gastroenterol Clin North Am. 29:819–827. 2000.

17 

Fukuhara K, Osugi H, Takada N, et al: Duodenogastric reflux eradicates Helicobacter pylori after distal gastrectomy. Hepatogastroenterology. 51:1548–1550. 2004.PubMed/NCBI

18 

Abe H, Murakami K, Satoh S, et al: Influence of bile reflux and Helicobacter pylori infection on gastritis in the remnant gastric mucosa after distal gastrectomy. J Gastroenterol. 40:563–569. 2005.PubMed/NCBI

19 

Nakagawara H, Miwa K, Nakamura S and Hattori T: Duodenogastric reflux sustains Helicobacter pylori infection in the gastric stump. Scand J Gastroenterol. 38:931–937. 2003. View Article : Google Scholar

20 

Matsukura N, Tajiri T, Kato S, et al: Helicobacter pylori eradication therapy for the remnant stomach after gastrectomy. Gastric Cancer. 6:100–107. 2003.

21 

Kato S, Matsukura N, Matsuda N, Tsuchiya S, Naito Z and Tajiri T: Normalization of pH level and gastric mucosa after eradication of H. pylori in the remnant stomach. J Gastroenterol Hepatol. 23(Suppl 2): S258–S261. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Giuliani A, Galati G, Demoro M, Scimò M, Pecorella I and Basso L: Screening of Helicobacter pylori infection after gastrectomy for cancer or peptic ulcer: results of a cohort study. Arch Surg. 145:962–967. 2010.

23 

Fujimura T, Fushida S, Kayahara M, Ohta T, Kinami S and Miwa K: Transectional gastrectomy: an old but renewed concept for early gastric cancer. Surg Today. 40:398–403. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Kitagawa Y and Kitajima M: Diagnostic validity of radio-guided sentinel node mapping for gastric cancer: a review of current status and future direction. Surg Technol Int. 15:32–36. 2006.PubMed/NCBI

25 

Keren D, Matter I, Rainis T, Goldstein O, Stermer E and Lavy A: Sleeve gastrectomy leads to Helicobacter pylori eradication. Obes Surg. 19:751–756. 2009. View Article : Google Scholar

26 

Deguchi R, Matsushima M, Suzuki T, et al: Comparison of a monoclonal with a polyclonal antibody-based enzyme immunoassay stool test in diagnosing Helicobacter pylori infection after eradication therapy. J Gastroenterol. 44:713–716. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Hooton C, Keohane J, Clair J, et al: Comparison of three stool antigen assays with the 13C-urea breath test for the primary diagnosis of Helicobacter pylori infection and monitoring treatment outcome. Eur J Gastroenterol Hepatol. 18:595–599. 2006.PubMed/NCBI

28 

Ceken N, Yurtsever SG, Baran N, Alper E, Buyrac Z and Unsal B: Comparison of Helicobacter pylori antibody detection in stool with other diagnostic tests for infection. Asian Pac J Cancer Prev. 12:1077–1081. 2011.

29 

Osugi H, Fukuhara K, Takada N, Takemura M and Kinoshita H: Reconstructive procedure after distal gastrectomy to prevent remnant gastritis. Hepatogastroenterology. 51:1215–1218. 2004.PubMed/NCBI

30 

Chan DC, Fan YM, Lin CK, Chen CJ, Chen CY and Chao YC: Roux-en-Y reconstruction after distal gastrectomy to reduce enterogastric reflux and Helicobacter pylori infection. J Gastrointest Surg. 11:1732–1740. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Onoda N, Katsuragi K, Sawada T, et al: Efficacy of Helicobacter pylori eradication on the chronic mucosal inflammation of the remnant stomach after distal gastrectomy for early gastric cancer. J Exp Clin Cancer Res. 24:515–521. 2005.

32 

Hamaguchi K, Ogawa K, Katsube T, Konno S and Aiba M: Does eradication of Helicobacter pylori reduce the risk of carcinogenesis in the residual stomach after gastrectomy for early gastric cancer? Comparison of mucosal lesions in the residual stomach before and after Helicobacter pylori eradication. Langenbecks Arch Surg. 389:83–91. 2004.

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Copy and paste a formatted citation
Spandidos Publications style
Miyashita T, Miwa K, Inokuchi M, Nakagawara H, Tajima H, Takamura H, Ninomiya I, Kitagawa H, Fushida S, Fujimura T, Fujimura T, et al: Spontaneous clearance of Helicobacter pylori after pylorus-preserving gastrectomy for gastric cancer. Oncol Rep 30: 299-303, 2013.
APA
Miyashita, T., Miwa, K., Inokuchi, M., Nakagawara, H., Tajima, H., Takamura, H. ... Ohta, T. (2013). Spontaneous clearance of Helicobacter pylori after pylorus-preserving gastrectomy for gastric cancer. Oncology Reports, 30, 299-303. https://doi.org/10.3892/or.2013.2472
MLA
Miyashita, T., Miwa, K., Inokuchi, M., Nakagawara, H., Tajima, H., Takamura, H., Ninomiya, I., Kitagawa, H., Fushida, S., Fujimura, T., Hattori, T., Ohta, T."Spontaneous clearance of Helicobacter pylori after pylorus-preserving gastrectomy for gastric cancer". Oncology Reports 30.1 (2013): 299-303.
Chicago
Miyashita, T., Miwa, K., Inokuchi, M., Nakagawara, H., Tajima, H., Takamura, H., Ninomiya, I., Kitagawa, H., Fushida, S., Fujimura, T., Hattori, T., Ohta, T."Spontaneous clearance of Helicobacter pylori after pylorus-preserving gastrectomy for gastric cancer". Oncology Reports 30, no. 1 (2013): 299-303. https://doi.org/10.3892/or.2013.2472
Copy and paste a formatted citation
x
Spandidos Publications style
Miyashita T, Miwa K, Inokuchi M, Nakagawara H, Tajima H, Takamura H, Ninomiya I, Kitagawa H, Fushida S, Fujimura T, Fujimura T, et al: Spontaneous clearance of Helicobacter pylori after pylorus-preserving gastrectomy for gastric cancer. Oncol Rep 30: 299-303, 2013.
APA
Miyashita, T., Miwa, K., Inokuchi, M., Nakagawara, H., Tajima, H., Takamura, H. ... Ohta, T. (2013). Spontaneous clearance of Helicobacter pylori after pylorus-preserving gastrectomy for gastric cancer. Oncology Reports, 30, 299-303. https://doi.org/10.3892/or.2013.2472
MLA
Miyashita, T., Miwa, K., Inokuchi, M., Nakagawara, H., Tajima, H., Takamura, H., Ninomiya, I., Kitagawa, H., Fushida, S., Fujimura, T., Hattori, T., Ohta, T."Spontaneous clearance of Helicobacter pylori after pylorus-preserving gastrectomy for gastric cancer". Oncology Reports 30.1 (2013): 299-303.
Chicago
Miyashita, T., Miwa, K., Inokuchi, M., Nakagawara, H., Tajima, H., Takamura, H., Ninomiya, I., Kitagawa, H., Fushida, S., Fujimura, T., Hattori, T., Ohta, T."Spontaneous clearance of Helicobacter pylori after pylorus-preserving gastrectomy for gastric cancer". Oncology Reports 30, no. 1 (2013): 299-303. https://doi.org/10.3892/or.2013.2472
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