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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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August 2013 Volume 30 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Anticancer activity of oncolytic adenoviruses carrying p53 is augmented by 11R in gallbladder cancer cell lines in vitro and in vivo

  • Authors:
    • Jinghan Wang
    • Yong Yu
    • Zi Yan
    • Zhenli Hu
    • Linfang Li
    • Jiang Li
    • Xiaoqing Jiang
    • Qijun Qian

  • View Affiliations / Copyright

    Affiliations: Laboratory of Viral and Gene Therapy, Eastern Hepatobiliary Surgical Hospital, The Second Military Medical University, Shanghai 200438, P.R. China, The First Department of Biliary Surgery, Eastern Hepatobiliary Surgical Hospital, The Second Military Medical University, Shanghai 200438, P.R. China, Department of Respiratory Medicine, Changhai Hospital, The Second Military Medical University, Shanghai 200438, P.R. China
  • Pages: 833-841
    |
    Published online on: May 31, 2013
       https://doi.org/10.3892/or.2013.2511
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Abstract

Gallbladder cancer (GBC) is a rare disease associated with an extremely poor patient prognosis, and occasionally, aberrant expression of p53 is present. Considering that p53 is one of the most widely studied tumor‑suppressor genes, we used a cell-penetrating peptide, 11R, to enhance the transferring efficiency of the oncolytic adenovirus carrying the p53 gene by constructing SG7605-11R-p53, a gene-viral therapy system which has higher specificity, enhanced safety, and efficacy. After infection with SG7605-11R-p53 at a multiplicity of infection (MOI) of 1 PFU/cell in vitro, the survival rate of EH-GB1 cells was lower than 50%, and that of EH-GB2 cells was lower than 40%, while the survival rate was higher than 90% for BJ human fibroblast cells, demonstrating that SG7605-11R-p53 has potent specific cytotoxicity against GBC cells. The tumor growth was greatly inhibited in nude mice bearing EH-GB2 xenografts when the total dose of SG7605-11R-p53 was 1x109 PFU, and terminal dUTP nick end-labeling (TUNEL) revealed that the apoptotic rate of cancer cells was 66.75±6.702%. Compared with existing gene therapy with long-standing shortcomings, our new system offers an additional option for patients with advanced GBC and other cancers who may not be suitable for chemotherapy, radiotherapy or who are not indicated for surgical treatment.

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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Yu Y, Yan Z, Hu Z, Li L, Li J, Jiang X and Qian Q: Anticancer activity of oncolytic adenoviruses carrying p53 is augmented by 11R in gallbladder cancer cell lines in vitro and in vivo. Oncol Rep 30: 833-841, 2013.
APA
Wang, J., Yu, Y., Yan, Z., Hu, Z., Li, L., Li, J. ... Qian, Q. (2013). Anticancer activity of oncolytic adenoviruses carrying p53 is augmented by 11R in gallbladder cancer cell lines in vitro and in vivo. Oncology Reports, 30, 833-841. https://doi.org/10.3892/or.2013.2511
MLA
Wang, J., Yu, Y., Yan, Z., Hu, Z., Li, L., Li, J., Jiang, X., Qian, Q."Anticancer activity of oncolytic adenoviruses carrying p53 is augmented by 11R in gallbladder cancer cell lines in vitro and in vivo". Oncology Reports 30.2 (2013): 833-841.
Chicago
Wang, J., Yu, Y., Yan, Z., Hu, Z., Li, L., Li, J., Jiang, X., Qian, Q."Anticancer activity of oncolytic adenoviruses carrying p53 is augmented by 11R in gallbladder cancer cell lines in vitro and in vivo". Oncology Reports 30, no. 2 (2013): 833-841. https://doi.org/10.3892/or.2013.2511
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Yu Y, Yan Z, Hu Z, Li L, Li J, Jiang X and Qian Q: Anticancer activity of oncolytic adenoviruses carrying p53 is augmented by 11R in gallbladder cancer cell lines in vitro and in vivo. Oncol Rep 30: 833-841, 2013.
APA
Wang, J., Yu, Y., Yan, Z., Hu, Z., Li, L., Li, J. ... Qian, Q. (2013). Anticancer activity of oncolytic adenoviruses carrying p53 is augmented by 11R in gallbladder cancer cell lines in vitro and in vivo. Oncology Reports, 30, 833-841. https://doi.org/10.3892/or.2013.2511
MLA
Wang, J., Yu, Y., Yan, Z., Hu, Z., Li, L., Li, J., Jiang, X., Qian, Q."Anticancer activity of oncolytic adenoviruses carrying p53 is augmented by 11R in gallbladder cancer cell lines in vitro and in vivo". Oncology Reports 30.2 (2013): 833-841.
Chicago
Wang, J., Yu, Y., Yan, Z., Hu, Z., Li, L., Li, J., Jiang, X., Qian, Q."Anticancer activity of oncolytic adenoviruses carrying p53 is augmented by 11R in gallbladder cancer cell lines in vitro and in vivo". Oncology Reports 30, no. 2 (2013): 833-841. https://doi.org/10.3892/or.2013.2511
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