Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
August 2013 Volume 30 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August 2013 Volume 30 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

microRNA detection in feces, sputum, pleural effusion and urine: Novel tools for cancer screening (Review)

  • Authors:
    • Yu-Feng Xiao
    • Xin Yong
    • Ya-Han Fan
    • Mu-Han Lü
    • Shi-Ming Yang
    • Chang-Jiang Hu
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, P.R. China
  • Pages: 535-544
    |
    Published online on: June 7, 2013
       https://doi.org/10.3892/or.2013.2525
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

microRNAs (miRNAs) are short non-coding RNA sequences that play important roles in the regulation of gene expression. They have significant regulatory functions in basic cellular processes, including differentiation, proliferation and apoptosis. miRNAs are differentially expressed in tumors, compared with normal tissues. Importantly, miRNAs are also stable and abundantly present in body fluids and feces. The high reproducibility, sensitivity and specificity of miRNAs in body fluids and feces enable miRNAs to be used as potential molecular markers for cancer screening. An increasingly large number of research studies have reported the role of miRNAs in this field. In the present review, we focused mainly on the application of detecting miRNAs in stool, sputum, pleural effusion and urine, to detect colon, lung and urological cancers, highlighting the role of miRNAs in early diagnosis and prognosis.
View Figures

Figure 1

View References

1 

Corte H, Manceau G, Blons H and Laurent-Puig P: MicroRNA and colorectal cancer. Digest Liver Dis. 44:195–200. 2012. View Article : Google Scholar

2 

Jemal A, Siegel R, Ward E, Hao YP, Xu JQ and Thun MJ: Cancer Statistics, 2009. CA Cancer J Clin. 59:225–249. 2009. View Article : Google Scholar

3 

Frost JK, Ball WC Jr, Levin ML, et al: Early lung cancer detection: results of the initial (prevalence) radiologic and cytologic screening in the Johns Hopkins study. Am Rev Respir Dis. 130:549–554. 1984.PubMed/NCBI

4 

Flehinger BJ, Kimmel M and Melamed MR: The effect of surgical treatment on survival from early lung cancer. Implications for screening. Chest. 101:1013–1018. 1992. View Article : Google Scholar : PubMed/NCBI

5 

Patz EF Jr, Rossi S, Harpole DH Jr, Herndon JE and Goodman PC: Correlation of tumor size and survival in patients with stage IA non-small cell lung cancer. Chest. 117:1568–1571. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Yu L, Todd NW, Xing LX, et al: Early detection of lung adenocarcinoma in sputum by a panel of microRNA markers. Int J Cancer. 127:2870–2878. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Subramanian J and Simon R: Gene expression-based prognostic signatures in lung cancer: ready for clinical use? J Natl Cancer Inst. 102:464–474. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Greer KB and Cooper GS: Receipt of colonoscopy is key to reduction of colorectal cancer mortality. Gastrointest Endosc. 76:365–366. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Chang KC and Yew WW: What is the role of autofluorescence bronchoscopy in screening lung cancer among silicotic subjects? reply. Int J Tuberc Lung Dis. 15:1277–1278. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Blick CG, Nazir SA, Mallett S, et al: Evaluation of diagnostic strategies for bladder cancer using computed tomography (CT) urography, flexible cystoscopy and voided urine cytology: results for 778 patients from a hospital haematuria clinic. BJU Int. 110:84–94. 2012. View Article : Google Scholar

11 

Ladabaum U and Song K: Projected national impact of colorectal cancer screening on clinical and economic outcomes and health services demand. Gastroenterology. 129:1151–1162. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Toloza EM, Harpole L and McCrory DC: Noninvasive staging of non-small cell lung cancer: a review of the current evidence. Chest. 123:137S–146S. 2003. View Article : Google Scholar : PubMed/NCBI

13 

van Rhijn BW, van der Poel HG and van der Kwast TH: Urine markers for bladder cancer surveillance: a systematic review. Eur Urol. 47:736–748. 2005.

14 

Thunnissen FB: Sputum examination for early detection of lung cancer. J Clin Pathol. 56:805–810. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Simon MA, Lokeshwar VB and Soloway MS: Current bladder cancer tests: unnecessary or beneficial? Crit Rev Oncol Hematol. 47:91–107. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Bassi P, De Marco V, De Lisa A, et al: Non-invasive diagnostic tests for bladder cancer: a review of the literature. Urol Int. 75:193–200. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Esquela-Kerscher A and Slack FJ: Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer. 6:259–269. 2006. View Article : Google Scholar

18 

Shenouda SK and Alahari SK: MicroRNA function in cancer: oncogene or a tumor suppressor? Cancer Metastasis Rev. 28:369–378. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Patnaik SK, Kannisto E, Mallick R and Yendamuri S: Overexpression of the lung cancer-prognostic miR-146b microRNAs has a minimal and negative effect on the malignant phenotype of A549 lung cancer cells. PLoS One. 6:e223792011.PubMed/NCBI

20 

Kong YW, Ferland-McCollough D, Jackson TJ and Bushell M: microRNAs in cancer management. Lancet Oncol. 13:E249–E258. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Calin GA and Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer. 6:857–866. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Harfe BD: MicroRNAs in vertebrate development. Curr Opin Genet Dev. 15:410–415. 2005. View Article : Google Scholar

24 

Kloosterman WP and Plasterk RHA: The diverse functions of microRNAs in animal development and disease. Dev Cell. 11:441–450. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Mandke P, Wyatt N, Fraser J, Bates B, Berberich SJ and Markey MP: MicroRNA-34a modulates MDM4 expression via a target site in the open reading frame. PLoS One. 7:e420342012. View Article : Google Scholar : PubMed/NCBI

26 

Lewis BP, Burge CB and Bartel DP: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 120:15–20. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Chen X, Ba Y, Ma L, et al: Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res. 18:997–1006. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Mitchell PS, Parkin RK, Kroh EM, et al: Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA. 105:10513–10518. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Taylor DD and Gercel-Taylor C: MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol Oncol. 110:13–21. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Ho AS, Huang X, Cao HB, et al: Circulating miR-210 as a novel hypoxia marker in pancreatic cancer. Transl Oncol. 3:109–113. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Wu CW, Ng SSM, Dong YJ, et al: Detection of miR-92a and miR-21 in stool samples as potential screening biomarkers for colorectal cancer and polyps. Gut. 61:739–745. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Xie Y, Todd NW, Liu ZQ, et al: Altered miRNA expression in sputum for diagnosis of non-small cell lung cancer. Lung Cancer. 67:170–176. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Brase JC, Wuttig D, Kuner R and Sultmann H: Serum microRNAs as non-invasive biomarkers for cancer. Mol Cancer. 9:3062010. View Article : Google Scholar : PubMed/NCBI

34 

Caby MP, Lankar D, Vincendeau-Scherrer C, Raposo G and Bonnerot C: Exosomal-like vesicles are present in human blood plasma. Int Immunol. 17:879–887. 2005. View Article : Google Scholar : PubMed/NCBI

35 

van Niel G, Porto-Carreiro I, Simoes S and Raposo G: Exosomes: a common pathway for a specialized function. J Biochem. 140:13–21. 2006.PubMed/NCBI

36 

Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ and Lotvall JO: Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 9:654–672. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Hunter MP, Ismail N, Zhang X, et al: Detection of microRNA expression in human peripheral blood microvesicles. PLoS One. 3:e36942008. View Article : Google Scholar : PubMed/NCBI

38 

Rabinowits G, Gercel-Taylor C, Day JM, Taylor DD and Kloecker GH: Exosomal microRNA: a diagnostic marker for lung cancer. Clin Lung Cancer. 10:42–46. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Skog J, Wurdinger T, van Rijn S, et al: Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol. 10:1470–1476. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Yu Z and Hecht NB: The DNA/RNA-binding protein, translin, binds microRNA122a and increases its in vivo stability. J Androl. 29:572–579. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Xie L, Chen X, Wang L, et al: Cell-free miRNAs may indicate diagnosis and docetaxel sensitivity of tumor cells in malignant effusions. BMC Cancer. 10:5912010. View Article : Google Scholar : PubMed/NCBI

42 

Levine JS and Ahnen DJ: Clinical practice. Adenomatous polyps of the colon. N Engl J Med. 355:2551–2557. 2006. View Article : Google Scholar : PubMed/NCBI

43 

Levin B, Lieberman DA, McFarland B, et al: Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. Gastroenterology. 134:1570–1595. 2008. View Article : Google Scholar

44 

Lieberman DA and Weiss DG: One-time screening for colorectal cancer with combined fecal occult-blood testing and examination of the distal colon. N Engl J Med. 345:555–560. 2001. View Article : Google Scholar : PubMed/NCBI

45 

Imperiale TF, Ransohoff DF, Itzkowitz SH, Turnbull BA and Ross ME: Fecal DNA versus fecal occult blood for colorectal-cancer screening in an average-risk population. N Engl J Med. 351:2704–2714. 2004. View Article : Google Scholar : PubMed/NCBI

46 

Hewitson P, Glasziou P, Irwig L, Towler B and Watson E: Screening for colorectal cancer using the faecal occult blood test, Hemoccult. Cochrane Database Syst Rev. CD0012162007. View Article : Google Scholar

47 

Cotton PB, Durkalski VL, Benoit PC, et al: Computed tomographic colonography (virtual colonoscopy): a multicenter comparison with standard colonoscopy for detection of colorectal neoplasia. JAMA. 291:1713–1719. 2004. View Article : Google Scholar : PubMed/NCBI

48 

Mulhall BP, Veerappan GR and Jackson JL: Meta-analysis: computed tomographic colonography. Ann Intern Med. 142:635–650. 2005. View Article : Google Scholar : PubMed/NCBI

49 

Johnson CD, Chen MH, Toledano AY, et al: Accuracy of CT colonography for detection of large adenomas and cancers. New Engl J Med. 359:1207–1217. 2008. View Article : Google Scholar : PubMed/NCBI

50 

Coady-Fariborzian L, Angel LP and Procaccino JA: Perforated colon secondary to virtual colonoscopy: report of a case. Dis Colon Rectum. 47:1247–1249. 2004. View Article : Google Scholar : PubMed/NCBI

51 

Kanaoka S, Yoshida K, Miura N, Sugimura H and Kajimura M: Potential usefulness of detecting cyclooxygenase 2 messenger RNA in feces for colorectal cancer screening. Gastroenterology. 127:422–427. 2004. View Article : Google Scholar : PubMed/NCBI

52 

Ahlquist DA, Sargent DJ, Loprinzi CL, et al: Stool DNA and occult blood testing for screen detection of colorectal neoplasia. Ann Intern Med. 149:441–450. W4812008. View Article : Google Scholar : PubMed/NCBI

53 

Brand RE, Ross ME and Shuber AP: Reproducibility of a multitarget stool-based DNA assay for colorectal cancer detection. Am J Gastroenterol. 99:1338–1341. 2004. View Article : Google Scholar : PubMed/NCBI

54 

Calistri D, Rengucci C, Bocchini R, Saragoni L, Zoli W and Amadori D: Fecal multiple molecular tests to detect colorectal cancer in stool. Clin Gastroenterol Hepatol. 1:377–383. 2003. View Article : Google Scholar : PubMed/NCBI

55 

Yu YJ, Majumdar AP, Nechvatal JM, et al: Exfoliated cells in stool: a source for reverse transcription-PCR-based analysis of biomarkers of gastrointestinal cancer. Cancer Epidemiol Biomarkers Prev. 17:455–458. 2008.PubMed/NCBI

56 

Zauber AG, Levin TR, Jaffe CC, Galen BA, Ransohoff DF and Brown ML: Implications of new colorectal cancer screening technologies for primary care practice. Med Care. 46:S138–S146. 2008. View Article : Google Scholar : PubMed/NCBI

57 

Aslam MI, Taylor K, Pringle JH and Jameson JS: MicroRNAs are novel biomarkers of colorectal cancer. Br J Surg. 96:702–710. 2009. View Article : Google Scholar : PubMed/NCBI

58 

Ahmed FE, Jeffries CD, Vos PW, et al: Diagnostic microRNA markers for screening sporadic human colon cancer and active ulcerative colitis in stool and tissue. Cancer Genomics Proteomics. 6:281–295. 2009.PubMed/NCBI

59 

Link A, Balaguer F, Shen Y, et al: Fecal MicroRNAs as novel biomarkers for colon cancer screening. Cancer Epidemiol Biomarkers Prev. 19:1766–1774. 2010. View Article : Google Scholar : PubMed/NCBI

60 

Kalimutho M, Del Vecchio Blanco G, Di Cecilia S, et al: Differential expression of miR-144* as a novel fecal-based diagnostic marker for colorectal cancer. J Gastroenterol. 46:1391–1402. 2011.

61 

Koga Y, Yasunaga M, Takahashi A, et al: MicroRNA expression profiling of exfoliated colonocytes isolated from feces for colorectal cancer screening. Cancer Prev Res. 3:1435–1442. 2010. View Article : Google Scholar : PubMed/NCBI

62 

Li JM, Zhao RH, Li ST, et al: Down-regulation of fecal miR-143 and miR-145 as potential markers for colorectal cancer. Saudi Med J. 33:24–29. 2012.PubMed/NCBI

63 

Kalimutho M, Di Cecilia S, Blanco GD, et al: Epigenetically silenced miR-34b/c as a novel faecal-based screening marker for colorectal cancer. Br J Cancer. 104:1770–1778. 2011. View Article : Google Scholar : PubMed/NCBI

64 

Greenlee RT, Hill-Harmon MB, Murray T and Thun M: Cancer statistics, 2001. CA Cancer J Clin. 51:15–36. 2001. View Article : Google Scholar

65 

Xing LX, Todd NW, Yu L, Fang HB and Jiang F: Early detection of squamous cell lung cancer in sputum by a panel of microRNA markers. Modern Pathol. 23:1157–1164. 2010. View Article : Google Scholar : PubMed/NCBI

66 

Akira M: High-resolution CT in the evaluation of occupational and environmental disease. Radiol Clin North Am. 40:43–59. 2002. View Article : Google Scholar : PubMed/NCBI

67 

Bastarrika G, Garcia-Velloso MJ, Lozano MD, et al: Early lung cancer detection using spiral computed tomography and positron emission tomography. Am J Respir Crit Care Med. 171:1378–1383. 2005. View Article : Google Scholar : PubMed/NCBI

68 

Gohagan JK, Marcus PM, Fagerstrom RM, et al: Final results of the Lung Screening Study, a randomized feasibility study of spiral CT versus chest X-ray screening for lung cancer. Lung Cancer. 47:9–15. 2005. View Article : Google Scholar : PubMed/NCBI

69 

Swensen SJ, Jett JR, Hartman TE, et al: Lung cancer screening with CT: Mayo Clinic experience. Radiology. 226:756–761. 2003. View Article : Google Scholar : PubMed/NCBI

70 

Koga H, Eguchi K, Shinkai T, et al: Preliminary evaluation of the new tumor marker, CYFRA 21-1, in lung cancer patients. Jpn J Clin Oncol. 24:263–268. 1994.PubMed/NCBI

71 

Sun S, Schiller JH and Gazdar AF: Lung cancer in never smokers: a different disease. Nat Rev Cancer. 7:778–790. 2007. View Article : Google Scholar : PubMed/NCBI

72 

Hirsch FR, Franklin WA, Gazdar AF and Bunn PA Jr: Early detection of lung cancer: clinical perspectives of recent advances in biology and radiology. Clin Cancer Res. 7:5–22. 2001.PubMed/NCBI

73 

Hassanein M, Callison JC, Callaway-Lane C, Aldrich MC, Grogan EL and Massion PP: The state of molecular biomarkers for the early detection of lung cancer. Cancer Prev Res. 5:992–1006. 2012. View Article : Google Scholar : PubMed/NCBI

74 

Belinsky SA: Gene-promoter hypermethylation as a biomarker in lung cancer. Nat Rev Cancer. 4:707–717. 2004. View Article : Google Scholar : PubMed/NCBI

75 

Castro M, Grau L, Puerta P, et al: Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in lung cancer. J Transl Med. 8:862010. View Article : Google Scholar : PubMed/NCBI

76 

Halling KC, Rickman OB, Kipp BR, Harwood AR, Doerr CH and Jett JR: A comparison of cytology and fluorescence in situ hybridization for the detection of lung cancer in bronchoscopic specimens. Chest. 130:694–701. 2006. View Article : Google Scholar : PubMed/NCBI

77 

Beane J, Sebastiani P, Whitfield TH, et al: A prediction model for lung cancer diagnosis that integrates genomic and clinical features. Cancer Prev Res. 1:56–64. 2008. View Article : Google Scholar : PubMed/NCBI

78 

Yanaihara N, Caplen N, Bowman E, et al: Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell. 9:189–198. 2006. View Article : Google Scholar : PubMed/NCBI

79 

Greenberg AK, Rimal B, Felner K, et al: S-adenosylmethionine as a biomarker for the early detection of lung cancer. Chest. 132:1247–1252. 2007. View Article : Google Scholar : PubMed/NCBI

80 

Showe MK, Vachani A, Kossenkov AV, et al: Gene expression profiles in peripheral blood mononuclear cells can distinguish patients with non-small cell lung cancer from patients with nonmalignant lung disease. Cancer Res. 69:9202–9210. 2009. View Article : Google Scholar

81 

Lai CY, Yu SL, Hsieh MH, et al: MicroRNA expression aberration as potential peripheral blood biomarkers for schizophrenia. PLoS One. 6:e216352011. View Article : Google Scholar : PubMed/NCBI

82 

Peck K, Sher YP, Shih JY, Roffler SR, Wu CW and Yang PC: Detection and quantitation of circulating cancer cells in the peripheral blood of lung cancer patients. Cancer Res. 58:2761–2765. 1998.PubMed/NCBI

83 

van der Drift MA, Prinsen CFM, Hol BEA, et al: Can free DNA be detected in sputum of lung cancer patients? Lung Cancer. 61:385–390. 2008.PubMed/NCBI

84 

Zhu S, Si ML, Wu H and Mo YY: MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1). J Biol Chem. 282:14328–14336. 2007. View Article : Google Scholar : PubMed/NCBI

85 

Neragi-Miandoab S: Malignant pleural effusion, current and evolving approaches for its diagnosis and management. Lung Cancer. 54:1–9. 2006. View Article : Google Scholar : PubMed/NCBI

86 

Wang T, Lv M, Shen S, et al: Cell-free microRNA expression profiles in malignant effusion associated with patient survival in non-small cell lung cancer. PLoS One. 7:e432682012. View Article : Google Scholar : PubMed/NCBI

87 

Lee JH, Hong YS, Ryu JS and Chang JH: p53 and FHIT mutations and microsatellite alterations in malignancy-associated pleural effusion. Lung Cancer. 44:33–42. 2004. View Article : Google Scholar : PubMed/NCBI

88 

Spector M and Pollak JS: Management of malignant pleural effusions. Semin Respir Crit Care Med. 29:405–413. 2008. View Article : Google Scholar : PubMed/NCBI

89 

Topolcan O, Holubec L, Polivkova V, et al: Tumor markers in pleural effusions. Anticancer Res. 27:1921–1924. 2007.PubMed/NCBI

90 

Katayama H, Hiraki A, Aoe K, et al: Aberrant promoter methylation in pleural fluid DNA for diagnosis of malignant pleural effusion. Int J Cancer. 120:2191–2195. 2007. View Article : Google Scholar : PubMed/NCBI

91 

Wang T, Qian X, Wang Z, et al: Detection of cell-free BIRC5 mRNA in effusions and its potential diagnostic value for differentiating malignant and benign effusions. Int J Cancer. 125:1921–1925. 2009. View Article : Google Scholar : PubMed/NCBI

92 

Nair VS, Maeda LS and Ioannidis JPA: Clinical outcome prediction by microRNAs in human cancer: a systematic review. J Natl Cancer Inst. 104:528–540. 2012. View Article : Google Scholar : PubMed/NCBI

93 

Jemal A, Siegel R, Xu J and Ward E: Cancer statistics, 2010. CA Cancer J Clin. 60:277–300. 2010. View Article : Google Scholar

94 

Snowdon J, Boag S, Feilotter H, Izard J and Siemens DR: A pilot study of urinary microRNA as a biomarker for urothelial cancer. Can Urol Assoc J. 7:28–32. 2013. View Article : Google Scholar : PubMed/NCBI

95 

Yamada Y, Enokida H, Kojima S, et al: MiR-96 and miR-183 detection in urine serve as potential tumor markers of urothelial carcinoma: correlation with stage and grade, and comparison with urinary cytology. Cancer Sci. 102:522–529. 2011. View Article : Google Scholar : PubMed/NCBI

96 

Ratliff TL: Urine markers for bladder cancer surveillance: a systematic review. J Urol. 174:2065–2066. 2005. View Article : Google Scholar : PubMed/NCBI

97 

Sarosdy MF, Hudson MA, Ellis WJ, et al: Improved detection of recurrent bladder cancer using the Bard BTA stat Test. Urology. 50:349–353. 1997. View Article : Google Scholar : PubMed/NCBI

98 

Carpinito GA, Stadler WM, Briggman JV, et al: Urinary nuclear matrix protein as a marker for transitional cell carcinoma of the urinary tract. J Urol. 156:1280–1285. 1996. View Article : Google Scholar : PubMed/NCBI

99 

Fradet Y and Lockhard C: Performance characteristics of a new monoclonal antibody test for bladder cancer: ImmunoCyt™. Can J Urol. 4:400–405. 1997.PubMed/NCBI

100 

Greenlee RT, Murray T, Bolden S and Wingo PA: Cancer statistics, 2000. CA Cancer J Clin. 50:7–33. 2000. View Article : Google Scholar

101 

Wang G, Chan ESY, Kwan BCH, et al: Expression of microRNAs in the urine of patients with bladder cancer. Clin Genitourin Cancer. 10:106–113. 2012. View Article : Google Scholar : PubMed/NCBI

102 

Roos PH and Jakubowski N: Methods for the discovery of low-abundance biomarkers for urinary bladder cancer in biological fluids. Bioanalysis. 2:295–309. 2010. View Article : Google Scholar : PubMed/NCBI

103 

Puerta-Gil P, Garcia-Baquero R, Jia AY, et al: miR-143, miR-222, and miR-452 are useful as tumor stratification and noninvasive diagnostic biomarkers for bladder cancer. Am J Pathol. 180:1808–1815. 2012. View Article : Google Scholar : PubMed/NCBI

104 

Hanke M, Hoefig K, Merz H, et al: A robust methodology to study urine microRNA as tumor marker: microRNA-126 and microRNA-182 are related to urinary bladder cancer. Urol Oncol. 28:655–661. 2010. View Article : Google Scholar : PubMed/NCBI

105 

Veerla S, Lindgren D, Kvist A, et al: MiRNA expression in urothelial carcinomas: important roles of miR-10a, miR-222, miR-125b, miR-7 and miR-452 for tumor stage and metastasis, and frequent homozygous losses of miR-31. Int J Cancer. 124:2236–2242. 2009. View Article : Google Scholar : PubMed/NCBI

106 

Han Y, Chen J, Zhao X, et al: MicroRNA expression signatures of bladder cancer revealed by deep sequencing. PLoS One. 6:e182862011. View Article : Google Scholar : PubMed/NCBI

107 

Noguchi S, Mori T, Hoshino Y, et al: MicroRNA-143 functions as a tumor suppressor in human bladder cancer T24 cells. Cancer Lett. 307:211–220. 2011. View Article : Google Scholar : PubMed/NCBI

108 

Kassouf W, Black PC, Tuziak T, et al: Distinctive expression pattern of ErbB family receptors signifies an aggressive variant of bladder cancer. J Urol. 179:353–358. 2008. View Article : Google Scholar : PubMed/NCBI

109 

Junttila TT, Laato M, Vahlberg T, et al: Identification of patients with transitional cell carcinoma of the bladder overexpressing ErbB2, ErbB3, or specific ErbB4 isoforms: real-time reverse transcription-PCR analysis in estimation of ErbB receptor status from cancer patients. Clin Cancer Res. 9:5346–5357. 2003.

110 

Cissell KA and Deo SK: Trends in microRNA detection. Anal Bioanal Chem. 394:1109–1116. 2009. View Article : Google Scholar : PubMed/NCBI

111 

de Planell-Saguer M and Rodicio MC: Analytical aspects of microRNA in diagnostics: a review. Anal Chim Acta. 699:134–152. 2011.PubMed/NCBI

112 

Ach RA, Wang H and Curry B: Measuring microRNAs: comparisons of microarray and quantitative PCR measurements, and of different total RNA prep methods. BMC Biotechnol. 8:692008. View Article : Google Scholar : PubMed/NCBI

113 

de Planell-Saguer M and Rodicio MC: Analytical aspects of microRNA in diagnostics: a review. Anal Chim Acta. 699:134–152. 2011.PubMed/NCBI

114 

Sarver AL: Toward understanding the informatics and statistical aspects of micro-RNA profiling. J Cardiovasc Transl Res. 3:204–211. 2010. View Article : Google Scholar : PubMed/NCBI

115 

Valoczi A, Hornyik C, Varga N, Burgyan J, Kauppinen S and Havelda Z: Sensitive and specific detection of microRNAs by northern blot analysis using LNA-modified oligonucleotide probes. Nucleic Acids Res. 32:e1752004. View Article : Google Scholar : PubMed/NCBI

116 

Pall GS, Codony-Servat C, Byrne J, Ritchie L and Hamilton A: Carbodiimide-mediated cross-linking of RNA to nylon membranes improves the detection of siRNA, miRNA and piRNA by northern blot. Nucleic Acids Res. 35:e602007. View Article : Google Scholar : PubMed/NCBI

117 

Varallyay E, Burgyan J and Havelda Z: MicroRNA detection by northern blotting using locked nucleic acid probes. Nat Protoc. 3:190–196. 2008. View Article : Google Scholar : PubMed/NCBI

118 

Chamnongpol S, Maroney PA and Nilsen TW: A rapid, quantitative assay for direct detection of microRNAs and other small RNAs using splinted ligation. Methods Mol Biol. 667:3–17. 2010. View Article : Google Scholar : PubMed/NCBI

119 

Cissell KA, Rahimi Y, Shrestha S, Hunt EA and Deo SK: Bioluminescence-based detection of microRNA, miR21 in breast cancer cells. Anal Chem. 80:2319–2325. 2008. View Article : Google Scholar : PubMed/NCBI

120 

Chen C, Ridzon DA, Broomer AJ, et al: Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res. 33:e1792005. View Article : Google Scholar : PubMed/NCBI

121 

Weaver S, Dube S, Mir A, et al: Taking qPCR to a higher level: analysis of CNV reveals the power of high throughput qPCR to enhance quantitative resolution. Methods. 50:271–276. 2010. View Article : Google Scholar : PubMed/NCBI

122 

Raymond CK, Roberts BS, Garrett-Engele P, Lim LP and Johnson JM: Simple, quantitative primer-extension PCR assay for direct monitoring of microRNAs and short-interfering RNAs. RNA. 11:1737–1744. 2005. View Article : Google Scholar : PubMed/NCBI

123 

Neely LA, Patel S, Garver J, et al: A single-molecule method for the quantitation of microRNA gene expression. Nat Methods. 3:41–46. 2006. View Article : Google Scholar : PubMed/NCBI

124 

Kloosterman WP, Wienholds E, de Bruijn E, Kauppinen S and Plasterk RHA: In situ detection of miRNAs in animal embryos using LNA-modified oligonucteotide probes. Nat Methods. 3:27–29. 2006. View Article : Google Scholar : PubMed/NCBI

125 

de Planell-Saguer M, Rodicio MC and Mourelatos Z: Rapid in situ codetection of noncoding RNAs and proteins in cells and formalin-fixed paraffin-embedded tissue sections without protease treatment. Nat Protoc. 5:1061–1073. 2010.PubMed/NCBI

126 

Obernosterer G, Martinez J and Alenius M: Locked nucleic acid-based in situ detection of microRNAs in mouse tissue sections. Nat Protoc. 2:1508–1514. 2007. View Article : Google Scholar : PubMed/NCBI

127 

Nelson PT, Baldwin DA, Kloosterman WP, Kauppinen S, Plasterk RHA and Mourelatos Z: RAKE and LNA-ISH reveal microRNA expression and localization in archival human brain. RNA. 12:187–191. 2006. View Article : Google Scholar : PubMed/NCBI

128 

Liu CG, Calin GA, Volinia S and Croce CM: MicroRNA expression profiling using microarrays. Nat Protoc. 3:563–578. 2008. View Article : Google Scholar : PubMed/NCBI

129 

Li W and Ruan KC: MicroRNA detection by microarray. Anal Bioanal Chem. 394:1117–1124. 2009. View Article : Google Scholar : PubMed/NCBI

130 

Nelson PT, Baldwin DA, Scearce LM, Oberholtzer JC, Tobias JW and Mourelatos Z: Microarray-based, high-throughput gene expression profiling of microRNAs. Nat Methods. 1:155–161. 2004. View Article : Google Scholar : PubMed/NCBI

131 

Takada S and Mano H: Profiling of microRNA expression by mRAP. Nat Protoc. 2:3136–3145. 2007. View Article : Google Scholar : PubMed/NCBI

132 

Volinia S, Calin GA, Liu CG, et al: A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA. 103:2257–2261. 2006. View Article : Google Scholar : PubMed/NCBI

133 

Weber JA, Baxter DH, Zhang SL, et al: The microRNA spectrum in 12 body fluids. Clin Chem. 56:1733–1741. 2010. View Article : Google Scholar : PubMed/NCBI

134 

Kanaan Z, Rai SN, Eichenberger MR, et al: Plasma miR-21: a potential diagnostic marker of colorectal cancer. Ann Surg. 256:544–551. 2012. View Article : Google Scholar : PubMed/NCBI

135 

Li BS, Zhao YL, Guo G, et al: Plasma microRNAs, miR-223, miR-21 and miR-218, as novel potential biomarkers for gastric cancer detection. PLoS One. 7:e416292012. View Article : Google Scholar : PubMed/NCBI

136 

Zhang X, Cui L, Ye G, et al: Gastric juice microRNA-421 is a new biomarker for screening gastric cancer. Tumour Biol. 33:2349–2355. 2012. View Article : Google Scholar : PubMed/NCBI

137 

Janakiram NB and Rao CV: Molecular markers and targets for colorectal cancer prevention. Acta Pharmacol Sin. 29:1–20. 2008. View Article : Google Scholar : PubMed/NCBI

138 

Dong Y, Wu WK, Wu CW, Sung JJ, Yu J and Ng SS: MicroRNA dysregulation in colorectal cancer: a clinical perspective. Br J Cancer. 104:893–898. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xiao Y, Yong X, Fan Y, Lü M, Yang S and Hu C: microRNA detection in feces, sputum, pleural effusion and urine: Novel tools for cancer screening (Review). Oncol Rep 30: 535-544, 2013.
APA
Xiao, Y., Yong, X., Fan, Y., Lü, M., Yang, S., & Hu, C. (2013). microRNA detection in feces, sputum, pleural effusion and urine: Novel tools for cancer screening (Review). Oncology Reports, 30, 535-544. https://doi.org/10.3892/or.2013.2525
MLA
Xiao, Y., Yong, X., Fan, Y., Lü, M., Yang, S., Hu, C."microRNA detection in feces, sputum, pleural effusion and urine: Novel tools for cancer screening (Review)". Oncology Reports 30.2 (2013): 535-544.
Chicago
Xiao, Y., Yong, X., Fan, Y., Lü, M., Yang, S., Hu, C."microRNA detection in feces, sputum, pleural effusion and urine: Novel tools for cancer screening (Review)". Oncology Reports 30, no. 2 (2013): 535-544. https://doi.org/10.3892/or.2013.2525
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao Y, Yong X, Fan Y, Lü M, Yang S and Hu C: microRNA detection in feces, sputum, pleural effusion and urine: Novel tools for cancer screening (Review). Oncol Rep 30: 535-544, 2013.
APA
Xiao, Y., Yong, X., Fan, Y., Lü, M., Yang, S., & Hu, C. (2013). microRNA detection in feces, sputum, pleural effusion and urine: Novel tools for cancer screening (Review). Oncology Reports, 30, 535-544. https://doi.org/10.3892/or.2013.2525
MLA
Xiao, Y., Yong, X., Fan, Y., Lü, M., Yang, S., Hu, C."microRNA detection in feces, sputum, pleural effusion and urine: Novel tools for cancer screening (Review)". Oncology Reports 30.2 (2013): 535-544.
Chicago
Xiao, Y., Yong, X., Fan, Y., Lü, M., Yang, S., Hu, C."microRNA detection in feces, sputum, pleural effusion and urine: Novel tools for cancer screening (Review)". Oncology Reports 30, no. 2 (2013): 535-544. https://doi.org/10.3892/or.2013.2525
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team