Cyclooxygenase-2 utilizes Jun N-terminal kinases to induce invasion, but not tamoxifen resistance, in MCF-7 breast cancer cells

  • Authors:
    • Vianey Gonzalez-Villasana
    • Yolanda Gutiérrez-Puente
    • Ana M. Tari
  • View Affiliations

  • Published online on: June 19, 2013     https://doi.org/10.3892/or.2013.2549
  • Pages: 1506-1510
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Abstract

Elevated cyclooxygenase-2 (COX-2) expression in breast tumors is associated with a lower survival rate in patients with estrogen receptor α (ERα)-positive tumors. We hypothesized that COX-2 reduces the survival rate of breast cancer patients with ERα-positive tumors since COX-2 increases the invasiveness of ERα-positive breast tumors and decreases tumor sensitivity to tamoxifen. Previously, we demonstrated that COX-2 stimulates the activity of protein kinase C (PKC) to increase the invasiveness of ERα-positive MCF-7 breast cancer cells and to decrease the sensitivity of MCF-7 cells to tamoxifen. High levels of COX-2 are associated with the activation of the mitogen-activated protein kinase (MAPK) family and the Akt kinase. However, it is not known whether these kinases mediate COX-2-induced invasive activity and tamoxifen resistance. In the present study, we report that COX-2 utilizes PKC to enhance the phosphorylation of Jun N-terminal kinases (JNKs), but not that of other MAPK family members or Akt. Inhibition aimed at JNKs reduced COX-2-induced invasion but not COX-2-induced tamoxifen resistance. We conclude that JNKs are essential for induced cell invasion by COX-2, but not tamoxifen resistance, in ERα-positive breast cancer cells.
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September 2013
Volume 30 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Gonzalez-Villasana V, Gutiérrez-Puente Y and Tari AM: Cyclooxygenase-2 utilizes Jun N-terminal kinases to induce invasion, but not tamoxifen resistance, in MCF-7 breast cancer cells. Oncol Rep 30: 1506-1510, 2013
APA
Gonzalez-Villasana, V., Gutiérrez-Puente, Y., & Tari, A.M. (2013). Cyclooxygenase-2 utilizes Jun N-terminal kinases to induce invasion, but not tamoxifen resistance, in MCF-7 breast cancer cells. Oncology Reports, 30, 1506-1510. https://doi.org/10.3892/or.2013.2549
MLA
Gonzalez-Villasana, V., Gutiérrez-Puente, Y., Tari, A. M."Cyclooxygenase-2 utilizes Jun N-terminal kinases to induce invasion, but not tamoxifen resistance, in MCF-7 breast cancer cells". Oncology Reports 30.3 (2013): 1506-1510.
Chicago
Gonzalez-Villasana, V., Gutiérrez-Puente, Y., Tari, A. M."Cyclooxygenase-2 utilizes Jun N-terminal kinases to induce invasion, but not tamoxifen resistance, in MCF-7 breast cancer cells". Oncology Reports 30, no. 3 (2013): 1506-1510. https://doi.org/10.3892/or.2013.2549