Journal Articles

Hereditary breast and ovarian cancer susceptibility genes (Review)

Hiroshi Kobayashi, Sumire Ohno, Yoshikazu Sasaki, Miyuki Matsuura

Pages: 1019-1029 Published online on: 19 June 2013
Open Access

Perspective: Opportunities in recalcitrant, rare and neglected tumors

Beverly A. Teicher

Pages: 1030-1034 Published online on: 02 July 2013
Open Access

Induction of apoptosis in MCF-7 cells by the hemagglutinin-neuraminidase glycoprotein of Newcastle disease virus Malaysian strain AF2240

Mohamed Ghrici, Mohamed El Zowalaty, Abdul Rahman Omar, Aini Ideris

Pages: 1035-1044 Published online on: 27 June 2013
Open Access

Application of PCR methods to evaluate EGFR, KRAS and BRAF mutations in a small number of tumor cells in cytological material from lung cancer patients

Marzena Anna Lewandowska, Wojciech Jóźwicki, Cezary Jochymski, Janusz Kowalewski

Pages: 1045-1052 Published online on: 01 July 2013
Open Access

Three missense mutations of DNA topoisomerase I in highly camptothecin-resistant colon cancer cell sublines

Yasuhiro Arakawa, Koji Ozaki, Yutaka Okawa, Hisashi Yamada

Pages: 1053-1058 Published online on: 05 July 2013
Open Access

Cantharidin and norcantharidin inhibit the ability of MCF-7 cells to adhere to platelets via protein kinase C pathway-dependent downregulation of α2 integrin

Liu-Mei Shou, Qiong-Yan Zhang, Wei Li, Xin Xie, Kai Chen, Lian Lian, Zhen-Yu Li, Fei-Ran Gong, Ke-Sheng Dai, Yi-Xiang Mao, Min Tao

Pages: 1059-1066 Published online on: 08 July 2013

Advantages of the rapid double-staining method for intraoperative detection of micrometastasis in sentinel lymph nodes

Toshihiko Ojima, Shinichi Kinami, Keishi Nakamura, Katsunobu Oyama, Masashi Inokuchi, Hideto Fujita, Itasu Ninomiya, Sachio Fushida, Takashi Fujimura, Seiko Kitamura, Shinichi Harada, Tetsuo Ohta

Pages: 1067-1072 Published online on: 04 July 2013

Increased expression of α-actinin-4 is associated with unfavorable pathological features and invasiveness of bladder cancer

Hidehiko Yoshii, Keiichi Ito, Takako Asano, Akio Horiguchi, Masamichi Hayakawa, Tomohiko Asano

Pages: 1073-1080 Published online on: 01 July 2013

Cetuximab promotes anticancer drug toxicity in rhabdomyosarcomas with EGFR amplification in vitro

Yuki Yamamoto, Kazumasa Fukuda, Yasushi Fuchimoto, Yumi Matsuzaki, Yoshiro Saikawa, Yuko Kitagawa, Yasuhide Morikawa, Tatsuo Kuroda

Pages: 1081-1086 Published online on: 04 July 2013

Enhanced antitumor activity of trastuzumab emtansine (T-DM1) in combination with pertuzumab in a HER2-positive gastric cancer model

Yoriko Yamashita-Kashima, Sei Shu, Naoki Harada, Kaori Fujimoto-Ouchi

Pages: 1087-1093 Published online on: 19 June 2013

A phase II study of a personalized peptide vaccination for chemotherapy-resistant advanced pancreatic cancer patients

Shigeru Yutani, Nobukazu Komatsu, Munehiro Yoshitomi, Satoko Matsueda, Koji Yonemoto, Takashi Mine, Masanori Noguchi, Yuki Ishihara, Akira Yamada, Kyogo Itoh, Tetsuro Sasada

Pages: 1094-1100 Published online on: 20 June 2013

Adenosine potentiates the therapeutic effects of neural stem cells expressing cytosine deaminase against metastatic brain tumors

Wonyoung Kang, Ho Jun Seol, Dong-Ho Seong, Jandi Kim, Yonghyun Kim, Seung U. Kim, Do-Hyun Nam, Kyeung Min Joo

Pages: 1101-1106 Published online on: 03 July 2013

Berberine induces apoptosis via the mitochondrial pathway in liver cancer cells

Novia K.Y. Yip, W. S. Ho

Pages: 1107-1112 Published online on: 19 June 2013

Acquisition of paclitaxel resistance via PI3K‑dependent epithelial‑mesenchymal transition in A2780 human ovarian cancer cells

Fangfang Du, Xiaohong Wu, Yanjun Liu, Teng Wang, Xiaowei Qi, Yong Mao, Li Jiang, Yifei Zhu, Yun Chen, Ruiyu  Zhu, Xiaofeng Han, Jian Jin, Xin Ma, Dong Hua

Pages: 1113-1118 Published online on: 26 June 2013

Glutathione and glutathione peroxidase expression in breast cancer: An immunohistochemical and molecular study

Bruna Victorasso Jardim, Marina Gobbe Moschetta, Camila Leonel, Gabriela Bottaro Gelaleti, Vitor Rafael Regiani, Lívia Carvalho Ferreira, Juliana Ramos Lopes, Debora Ap. Pires de Campos Zuccari

Pages: 1119-1128 Published online on: 13 June 2013

Pancreatic tumor mass in a xenograft mouse model is decreased by treatment with therapeutic stem cells following introduction of therapeutic genes

Doo-Jin Kim, Bo-Rim Yi, Hye-Rim Lee, Seung U. Kim, Kyung-Chul Choi

Pages: 1129-1136 Published online on: 25 June 2013

CHD8 is an independent prognostic indicator that regulates Wnt/β-catenin signaling and the cell cycle in gastric cancer

Genta Sawada, Hiroki Ueo, Tae Matsumura, Ryutaro Uchi, Masahisa Ishibashi, Kosuke Mima, Junji Kurashige, Yusuke Takahashi, Sayori Akiyoshi, Tomoya Sudo, Keishi Sugimachi, Yuichiro Doki, Masaki Mori, Koshi Mimori

Pages: 1137-1142 Published online on: 08 July 2013

Isolation and characterization of biliary epithelial and stromal cells from resected human cholangiocarcinoma: a novel in vitro model to study tumor-stroma interactions

Marco Massani, Tommaso Stecca, Luca Fabris, Ezio Caratozzolo, Cesare Ruffolo, Alberto Furlanetto, Stuart Morton, Massimiliano Cadamuro, Mario Strazzabosco, Nicolò Bassi

Pages: 1143-1148 Published online on: 26 June 2013

The relevance of EGFR overexpression for the prediction of the malignant transformation of oral leukoplakia

Jutta Ries, Eleftherios Vairaktaris, Abbas Agaimy, Moritz Bechtold, Patricia Gorecki, Friedrich W. Neukam, Emeka Nkenke

Pages: 1149-1156 Published online on: 19 June 2013

Overexpression of human telomerase reverse transcriptase promotes the motility and invasiveness of HepG2 cells in vitro

Peng-Cheng Chen, Ji-Run Peng, Lei Huang, Wen-Xia Li, Wen-Zhen  Wang, Zhu-Qing-Qing Cui, Hui Han, Lei Gong, Da-Peng Xiang, Shi-Shi  Qiao, Xin Yu, Yu-Hua Wei, Li-Ping Ma, Na Li, Ji-Ye Zhu, Xi-Sheng  Leng

Pages: 1157-1164 Published online on: 25 June 2013

Enhanced therapeutic efficacy of adenovirus-mediated interleukin-24 gene therapy combined with ionizing radiotherapy for nasopharyngeal carcinoma

Jisheng Liu, Yujuan Zhang, Peng Sun, Yufeng Xie, Jim Xiang, Jicheng Yang

Pages: 1165-1174 Published online on: 19 June 2013

T-cell apoptosis induced by intratumoral activated hepatic stellate cells is associated with lung metastasis in hepatocellular carcinoma

Yun-Hong Xia, Zhi-Ming Wang, Rong-Xin Chen, Sheng-Long Ye, Rui-Xia Sun, Qiong Xue, Yong Huang

Pages: 1175-1184 Published online on: 27 June 2013

Identification of molecular candidates and interaction networks via integrative toxicogenomic analysis in a human cell line following low-dose exposure to the carcinogenic metals cadmium and nickel

Jee Young Kwon, Jong-Il Weon, Preeyaporn Koedrith, Kang-Sik Park, Im Soon Kim, Young Rok Seo

Pages: 1185-1194 Published online on: 04 July 2013

Ammonium chloride enhances cisplatin cytotoxicity through DNA double-strand breaks in human cervical cancer cells

Ye Xu, Ning Wang, Yan Ding, Chunyan Wang, Yang Yu, Shibing Liu, Xiaojun Wang, Zhixin Li

Pages: 1195-1200 Published online on: 20 June 2013

EtBr-induced selective degradation of mitochondria occurs via autophagy

Yan Luo, Yide Hu, Minghui Zhang, Yu Xiao, Zongchang Song, Yu Xu

Pages: 1201-1208 Published online on: 04 July 2013

Thymidine kinase/ganciclovir and cytosine deaminase/5-fluorocytosine suicide gene therapy-induced cell apoptosis in breast cancer cells

H. Kong, L. Tao, K. Qi, Y. Wang, Q. Li, J. Du, Z. Huang

Pages: 1209-1214 Published online on: 21 June 2013

Prevalence of Th17 and Treg cells in gastric cancer patients and its correlation with clinical parameters

Qiaoxia Li, Qingjing Li, Jinxia Chen, Yu Liu, Xuefeng Zhao, Bibo Tan, Jun Ai, Zhiping Zhang, Jingjing Song, Baoen Shan

Pages: 1215-1222 Published online on: 27 June 2013

Regulation of miR-155 affects pancreatic cancer cell invasiveness and migration by modulating the STAT3 signaling pathway through SOCS1

Chen Huang, Haidong Li, Weidong Wu, Tao Jiang, Zhengjun Qiu

Pages: 1223-1230 Published online on: 28 June 2013

Induction of human leukemia U937 cell apoptosis by an ethanol extract of Dendropanax morbifera Lev. through the caspase-dependent pathway

Joon Wοο Lee, Cheol Park, Min Hο Han, Su Hyun Hong, Tae Kyung Lee, Shin Hwa Lee, Gi-Young Kim, Yung Hyun Choi

Pages: 1231-1238 Published online on: 19 June 2013

MicroRNA-128 promotes cell-cell adhesion in U87 glioma cells via regulation of EphB2

Lina Lin, Xulin Chen, Xuelin Peng, Jianwen Zhou, Hsiang-Fu Kung, Marie C. Lin, Songshan Jiang

Pages: 1239-1248 Published online on: 05 July 2013

Invasion potential of H22 hepatocarcinoma cells is increased by HMGB1-induced tumor NF-κB signaling via initiation of HSP70

Wei Gong, Zhi-Yong Wang, Guo-Xi Chen, Yu-Qiao Liu, Xiao-Yan Gu, Wen-Wei Liu

Pages: 1249-1256 Published online on: 05 July 2013

Cordycepin increases sensitivity of Hep3B human hepatocellular carcinoma cells to TRAIL-mediated apoptosis by inactivating the JNK signaling pathway

Hye Hyeon Lee, Jin-Woo Jeong, Jun Hyuk Lee, Gi-Young Kim, Jaehun  Cheong, Yong Kee Jeong, Young Hyun Yoo, Yung Hyun Choi

Pages: 1257-1264 Published online on: 04 July 2013

Profiling of the calcitonin-calcitonin receptor axis in primary prostate cancer: clinical implications and molecular correlates

Arvind Thakkar, Irene V. Bijnsdorp, Albert A. Geldof, Girish V. Shah

Pages: 1265-1274 Published online on: 02 July 2013

FAM9C plays an anti-apoptotic role through activation of the PI3K/Akt pathway in human hepatocellular carcinoma

Jun-Dong Zhou, Fei Shen, Jian-Song Ji, Kai Zheng, Min Huang, Jin-Chang Wu

Pages: 1275-1284 Published online on: 05 July 2013

miR-21 and its target gene CCL20 are both highly overexpressed in the microenvironment of colorectal tumors: Significance of their regulation

Benjamin Vicinus, Claudia Rubie, Nathalie Stegmaier, Vilma Oliveira Frick, Kathrin Kölsch, Anne Kauffels, Pirus Ghadjar, Mathias  Wagner, Matthias Glanemann

Pages: 1285-1292 Published online on: 01 July 2013

Histone deacetylase 4 mediates SMAD family member 4 deacetylation and induces 5-fluorouracil resistance in breast cancer cells

Seong-Lan Yu, Dong Chul Lee, Ji Woong Son, Chang Gyo Park, Hoi Young Lee, Jaeku Kang

Pages: 1293-1300 Published online on: 01 July 2013

Dual role of TGFBR3 in bladder cancer

Xiao-Long Liu, Kebing Xiao, Boxin Xue, Dongrong Yang, Zhe Lei, Yuxi Shan, Hong-Tao Zhang

Pages: 1301-1308 Published online on: 08 July 2013

Total alkaloids of Rubus aleaefolius Poir. inhibit the STAT3 signaling pathway leading to suppression of proliferation and cell cycle arrest in a mouse model of hepatocellular carcinoma

Jinyan Zhao, Wei Lin, Zhiyun Cao, Liya Liu, Qunchuan Zhuang, Xiaoyong Zhong, Zhenfeng Hong, Jun Peng

Pages: 1309-1314 Published online on: 03 July 2013

The overexpression of BAMBI and its involvement in the growth and invasion of human osteosarcoma cells

Lu Zhou, Jin Park, Kyu Yun Jang, Ho Sung Park, Sajeev Wagle, Kyu Hyun Yang, Kwang-Bok Lee, Byung-Hyun Park, Jung Ryul Kim

Pages: 1315-1322 Published online on: 26 June 2013

Sirt3 is a tumor suppressor in lung adenocarcinoma cells

Kui Xiao, Jiehan Jiang, Wei Wang, Shan Cao, Liming Zhu, Huihui Zeng, Ruoyun Ouyang, Rui Zhou, Ping Chen

Pages: 1323-1328 Published online on: 08 July 2013

Porphyromonas gingivalis lipopolysaccharide increases lipid accumulation by affecting CD36 and ATP-binding cassette transporter A1 in macrophages

Xiu-Ying Li, Chun Wang, Xue-Rong Xiang, Fang-Chun Chen, Cong-Ming Yang, Jing  Wu

Pages: 1329-1336 Published online on: 08 July 2013

The insulin-like growth factor-1 and expression of its binding protein‑3 in chronic hepatitis C and hepatocellular carcinoma

Agnieszka Adamek, Aldona Kasprzak, Hanna Mikoś, Wiesława  Przybyszewska, Agnieszka  Seraszek-Jaros, Arkadiusz  Czajka, Karolina  Sterzyńska, Iwona Mozer-Lisewska

Pages: 1337-1345 Published online on: 19 June 2013

Sterol regulatory element-binding protein 1 is required for ovarian tumor growth

Long-Yun Nie, Qing-Tao Lu, Wei-Hua Li, Ning Yang, Samina Dongol, Xin Zhang, Jie Jiang

Pages: 1346-1354 Published online on: 28 June 2013

GATA6 predicts prognosis and hepatic metastasis of colorectal cancer

Fei Shen, Jianglin Li, Wensong Cai, Guanghui Zhu, Weili Gu, Lin Jia, Bo Xu

Pages: 1355-1361 Published online on: 19 June 2013

Ginsenoside Rg3 induces apoptosis in the U87MG human glioblastoma cell line through the MEK signaling pathway and reactive oxygen species

Yoon Ji Choi, Hyun Joo Lee, Dong Wan Kang, In Ho Han, Byung Kwan Choi, Won Ho Cho

Pages: 1362-1370 Published online on: 20 June 2013

Reduced expression of mutS homolog 2 and mutL homolog 1 affects overall survival in laryngeal squamous cell carcinoma patients: Investigation into a potential cause

Hong-Li Gong, Yong Shi, Yi Shi, Chun-Ping Wu, Peng-Yu Cao, Liang Zhou, Chen Xu

Pages: 1371-1379 Published online on: 20 June 2013

High CCR6/CCR7 expression and Foxp3+ Treg cell number are positively related to the progression of laryngeal squamous cell carcinoma

Bin Chen, Duo Zhang, Jian Zhou, Qing Li, Lin Zhou, Shi-Min Li, Li Zhu, Kuang-Yen Chou, Liang Zhou, Lei Tao, Li-Ming Lu

Pages: 1380-1390 Published online on: 08 July 2013

Key genes and pathways in thyroid cancer based on gene set enrichment analysis

Wenwu He, Bin Qi, Qiuxi Zhou, Chuansen Lu, Qi Huang, Lei Xian, Mingwu Chen

Pages: 1391-1397 Published online on: 20 June 2013

miR‑133a suppresses cell proliferation, migration and invasion in human lung cancer by targeting MMP‑14

Meng Xu, Yu‑Zhou Wang

Pages: 1398-1404 Published online on: 19 June 2013

Antitumour effects of Yangzheng Xiaoji in human osteosarcoma: The pivotal role of focal adhesion kinase signalling

Wen G. Jiang, Lin Ye, Ke Ji, Fiona Ruge, Yiling Wu, Yong Gao, Jiafu Ji, Malcolm D. Mason

Pages: 1405-1413 Published online on: 03 July 2013

Overexpression of astrocyte-elevated gene-1 is associated with cervical carcinoma progression and angiogenesis

Min Long, Ke Dong, Ping Gao, Xi Wang, Li Liu, Shuhui Yang, Fang Lin, Junxia Wei, Huizhong Zhang

Pages: 1414-1422 Published online on: 08 July 2013

Notch1 destabilizes the adherens junction complex through upregulation of the Snail family of E-cadherin repressors in non-small cell lung cancer

Arum Kim, Eun Young Kim, Eun Na Cho, Hyung Jung Kim, Se Kyu Kim, Joon Chang, Chul Min Ahn, Yoon Soo Chang

Pages: 1423-1429 Published online on: 26 June 2013

Inhibition of Wnt signaling induces cell apoptosis and suppresses cell proliferation in cholangiocarcinoma cells

Kun-Song Zhang, Qi Zhou, Ya-Feng Wang, Li-Jian Liang

Pages: 1430-1438 Published online on: 21 June 2013

Patrinia scabiosaefolia inhibits colorectal cancer growth through suppression of tumor angiogenesis

Liwu Chen, Liya Liu, Ling Ye, Aling Shen, Youqin Chen, Thomas J. Sferra, Jun  Peng

Pages: 1439-1443 Published online on: 02 July 2013

Molecular basis for the regulation of hypoxia-inducible factor-1α levels by 2-deoxy-D-ribose

Ryuji Ikeda, Sho Tabata, Yusuke Tajitsu, Yukihiko Nishizawa, Kentaro Minami, Tatsuhiko Furukawa, Masatatsu Yamamoto, Yoshinari Shinsato, Shin-Ichi Akiyama, Katsushi Yamada, Yasuo Takeda

Pages: 1444-1448 Published online on: 27 June 2013

Loss of the metastasis suppressor gene KiSS1 is associated with lymph node metastasis and poor prognosis in human colorectal cancer

Yoshinaga Okugawa, Yasuhiro Inoue, Koji Tanaka, Yuji Toiyama, Tadanobu Shimura, Masato Okigami, Aya Kawamoto, Junichiro Hiro, Susumu Saigusa, Yasuhiko Mohri, Keiichi Uchida, Masato Kusunoki

Pages: 1449-1454 Published online on: 20 June 2013

Human erythropoietin increases the pro-angiogenic potential of A2780 ovarian adenocarcinoma cells under hypoxic conditions

Ján Kriška, Peter Solár, Lenka Varinská, Zuzana Solárová, Patrícia Kimáková, Ján Mojžiš, Peter Fedoročko, Arthur J. Sytkowski

Pages: 1455-1462 Published online on: 26 June 2013

Predictive and prognostic factors in second- and third-line erlotinib treatment in NSCLC patients with known status of the EGFR gene

Paweł Krawczyk, Dariusz M. Kowalski, Kamila Wojas Krawczyk, Michał  Szczyrek, Radosław Mlak, Andrzej Rolski, Aneta Szudy, Robert  Kieszko, Kinga  Winiarczyk, Janusz Milanowski, Maciej Krzakowski

Pages: 1463-1472 Published online on: 19 June 2013

Artesunate exerts specific cytotoxicity in retinoblastoma cells via CD71

Fei Zhao, Han Wang, Patricilia Kunda, Xuemei Chen, Qiu-Ling Liu, Tao Liu

Pages: 1473-1482 Published online on: 28 June 2013

Lentivirus-delivered short hairpin RNA targeting SNAIL inhibits HepG2 cell growth

Jing Liu, Gang Jiang, Shihai Liu, Zimin Liu, Huazheng Pan, Ruyong Yao, Jun Liang

Pages: 1483-1487 Published online on: 19 June 2013

Microarray analysis reveals that high mobility group A1 is involved in colorectal cancer metastasis

Yusuke Takahashi, Genta Sawada, Tetsuya Sato, Junji Kurashige, Kosuke Mima, Tae Matsumura, Ryutaro Uchi, Hiroki Ueo, Masahisa Ishibashi, Yuki Takano, Sayuri Akiyoshi, Hidetoshi Eguchi, Tomoya Sudo, Keishi Sugimachi, Jun‑Ichi Tanaka, Shin-Ei Kudo, Yuichiro Doki, Masaki Mori, Koshi Mimori

Pages: 1488-1496 Published online on: 08 July 2013

Aspirin antagonizes the cytotoxic effect of methotrexate in lung cancer cells

Kun-Huang Yan, Liang-Ming Lee, Mao-Chih Hsieh, Ming-De Yan, Chih-Jung Yao, Pey-Yi Chang, Tsung-Li Chen, Hwan-You Chang, Ann-Lii Cheng, Gi-Ming Lai, Shuang-En Chuang

Pages: 1497-1505 Published online on: 21 June 2013

Cyclooxygenase-2 utilizes Jun N-terminal kinases to induce invasion, but not tamoxifen resistance, in MCF-7 breast cancer cells

Vianey Gonzalez-Villasana, Yolanda Gutiérrez-Puente, Ana M. Tari

Pages: 1506-1510 Published online on: 19 June 2013

Promoter methylation of the DLC‑1 gene and its inhibitory effect on human colon cancer

Zhensheng Dai, Yueling Jin

Pages: 1511-1517 Published online on: 19 June 2013

The trefoil factor 1 (TFF1) protein involved in doxorubicin‑induced apoptosis resistance is upregulated by estrogen in breast cancer cells

Sonam Pelden, Tonkla Insawang, Chanitra Thuwajit, Peti Thuwajit

Pages: 1518-1526 Published online on: 05 July 2013
Journal Cover

September 2013
Volume 30 Issue 3

Print ISSN: 1021-335X
Online ISSN: 1791-2431

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