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September 2013 Volume 30 Issue 3

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

A phase II study of a personalized peptide vaccination for chemotherapy-resistant advanced pancreatic cancer patients

  • Authors:
    • Shigeru Yutani
    • Nobukazu Komatsu
    • Munehiro Yoshitomi
    • Satoko Matsueda
    • Koji Yonemoto
    • Takashi Mine
    • Masanori Noguchi
    • Yuki Ishihara
    • Akira Yamada
    • Kyogo Itoh
    • Tetsuro Sasada
  • View Affiliations / Copyright

    Affiliations: Department of Immunology and Immunotherapy, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan, Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan, Biostatistics Center, Kurume University, Kurume, Fukuoka 830-0011, Japan, Research Center for Innovative Cancer Therapy, Kurume University, Kurume, Fukuoka 830-0011, Japan
  • Pages: 1094-1100
    |
    Published online on: June 20, 2013
       https://doi.org/10.3892/or.2013.2556
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Abstract

Pancreatic cancer is one of the most aggressive cancers with a median survival time (MST) of <6 months in chemotherapy-resistant patients. Therefore, the development of novel treatment modalities is needed. In the present study, a phase II study of personalized peptide vaccination (PPV) was conducted, in which vaccine antigens were selected and administered based on the pre-existing IgG responses to 31 different pooled peptides, for 41 chemotherapy-resistant advanced pancreatic cancer patients. No vaccine-related severe adverse events were observed. IgG responses specific to at least one of the vaccine peptides were augmented in 14 of 36 patients (39%) and in 18 of 19 patients (95%) tested after the 5th and 11th vaccination, respectively. MST from the first vaccination was 7.9 months with a 1-year survival rate of 26.8%. Higher serum amyloid A (SAA) and C-reactive protein (CRP) levels in pre-vaccination plasma were unfavorable factors for overall survival (OS). Due to the safety profile and the potential clinical efficacy, the conduction of additional clinical trials of PPV for chemotherapy-resistant advanced pancreatic cancer patients is warranted.
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Copy and paste a formatted citation
Spandidos Publications style
Yutani S, Komatsu N, Yoshitomi M, Matsueda S, Yonemoto K, Mine T, Noguchi M, Ishihara Y, Yamada A, Itoh K, Itoh K, et al: A phase II study of a personalized peptide vaccination for chemotherapy-resistant advanced pancreatic cancer patients. Oncol Rep 30: 1094-1100, 2013.
APA
Yutani, S., Komatsu, N., Yoshitomi, M., Matsueda, S., Yonemoto, K., Mine, T. ... Sasada, T. (2013). A phase II study of a personalized peptide vaccination for chemotherapy-resistant advanced pancreatic cancer patients. Oncology Reports, 30, 1094-1100. https://doi.org/10.3892/or.2013.2556
MLA
Yutani, S., Komatsu, N., Yoshitomi, M., Matsueda, S., Yonemoto, K., Mine, T., Noguchi, M., Ishihara, Y., Yamada, A., Itoh, K., Sasada, T."A phase II study of a personalized peptide vaccination for chemotherapy-resistant advanced pancreatic cancer patients". Oncology Reports 30.3 (2013): 1094-1100.
Chicago
Yutani, S., Komatsu, N., Yoshitomi, M., Matsueda, S., Yonemoto, K., Mine, T., Noguchi, M., Ishihara, Y., Yamada, A., Itoh, K., Sasada, T."A phase II study of a personalized peptide vaccination for chemotherapy-resistant advanced pancreatic cancer patients". Oncology Reports 30, no. 3 (2013): 1094-1100. https://doi.org/10.3892/or.2013.2556
Copy and paste a formatted citation
x
Spandidos Publications style
Yutani S, Komatsu N, Yoshitomi M, Matsueda S, Yonemoto K, Mine T, Noguchi M, Ishihara Y, Yamada A, Itoh K, Itoh K, et al: A phase II study of a personalized peptide vaccination for chemotherapy-resistant advanced pancreatic cancer patients. Oncol Rep 30: 1094-1100, 2013.
APA
Yutani, S., Komatsu, N., Yoshitomi, M., Matsueda, S., Yonemoto, K., Mine, T. ... Sasada, T. (2013). A phase II study of a personalized peptide vaccination for chemotherapy-resistant advanced pancreatic cancer patients. Oncology Reports, 30, 1094-1100. https://doi.org/10.3892/or.2013.2556
MLA
Yutani, S., Komatsu, N., Yoshitomi, M., Matsueda, S., Yonemoto, K., Mine, T., Noguchi, M., Ishihara, Y., Yamada, A., Itoh, K., Sasada, T."A phase II study of a personalized peptide vaccination for chemotherapy-resistant advanced pancreatic cancer patients". Oncology Reports 30.3 (2013): 1094-1100.
Chicago
Yutani, S., Komatsu, N., Yoshitomi, M., Matsueda, S., Yonemoto, K., Mine, T., Noguchi, M., Ishihara, Y., Yamada, A., Itoh, K., Sasada, T."A phase II study of a personalized peptide vaccination for chemotherapy-resistant advanced pancreatic cancer patients". Oncology Reports 30, no. 3 (2013): 1094-1100. https://doi.org/10.3892/or.2013.2556
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