Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
September 2013 Volume 30 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September 2013 Volume 30 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Artesunate exerts specific cytotoxicity in retinoblastoma cells via CD71

  • Authors:
    • Fei Zhao
    • Han Wang
    • Patricilia Kunda
    • Xuemei Chen
    • Qiu-Ling Liu
    • Tao Liu
  • View Affiliations / Copyright

    Affiliations: Graduate Division, Xuzhou Medical College, Xuzhou, Jiangsu 221004, P.R. China, Poten Biomedical Institute for Cancer Immunotherapy, Shenzhen, Guangdong 518057, P.R. China, Department of Pediatrics, The General Hospital of The Chinese People's Armed Police Forces, Beijing 100039, P.R. China
  • Pages: 1473-1482
    |
    Published online on: June 28, 2013
       https://doi.org/10.3892/or.2013.2574
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Retinoblastoma (RB) is an intraocular cancer that affects young children. There is an ongoing effort to find new agents for RB management that are effective, specific and with few side-effects. In the present study, we tested artesunate (ART), a synthetic derivative from the herbal drug artemisinin, used in the clinic for the treatment of malaria. We analyzed ART cytotoxicity in an RB cell line (RB-Y79) and in a retinal epithelial cell line (hTERT-RPE1) by flow cytometric analysis (FCM). We related the effect of ART to the expression of transferrin receptor 1 (TfR-1, also known as CD71) by knocking down CD71 with RNAi and analyzing cell cycle variables by FCM. We found that the cytotoxic action of ART is specific for RB cells in a dose-dependent manner, with low toxicity in normal retina cells. ART is more effective in RB than carboplatin with a markedly strong cytotoxic effect on carboplatin-resistant RB cells. RB had higher CD71 levels at the membrane compared to normal retinal cells. We showed that ART internalization in RB cells is dependent upon the expression of the CD71. In addition, ART blocked the cell cycle progression at the G1 phase, even at low doses, and decreased the proportion of RB cells in the S phase. In conclusion, we showed that ART is a promising drug exhibiting high selective cytotoxicity even against multidrug-resistant RB cells. Thus, we suggest that ART could be used in the treatment of RB.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Shields CL and Shields JA: Recent developments in the management of retinoblastoma. J Pediatr Ophthalmol Strabismus. 36:8–18; quiz 35–36. 1999.

2 

Shields CL and Shields JA: Diagnosis and management of retinoblastoma. Cancer Control. 11:317–327. 2004.

3 

Dimaras H, Kahaki K, O’Dimba EA, et al: Retinoblastoma. Lancet. 379:1436–1446. 2012. View Article : Google Scholar

4 

Kivela T: The epidemiological challenge of the most frequent eye cancer: retinoblastoma, an issue of birth and death. Br J Ophthalmol. 93:1129–1131. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Bai S, Ren R, Shi J, et al: Retinoblastoma in the Beijing Tongren Hospital from 1957 to 2006: clinicopathological findings. Br J Ophthalmol. 95:1072–1076. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Zhao J, Li S, Shi J and Wang N: Clinical presentation and group classification of newly diagnosed intraocular retinoblastoma in China. Br J Ophthalmol. 95:1372–1375. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Samaila MO: Malignant tumours of childhood in Zaria. Afr J Paediatr Surg. 6:19–23. 2009. View Article : Google Scholar : PubMed/NCBI

8 

MacCarthy A, Draper GJ, Steliarova-Foucher E and Kingston JE: Retinoblastoma incidence and survival in European children (1978–1997). Report from the Automated Childhood Cancer Information System project. Eur J Cancer. 42:2092–2102. 2006.

9 

Broaddus E, Topham A and Singh AD: Incidence of retinoblastoma in the USA: 1975–2004. Br J Ophthalmol. 93:21–23. 2009.

10 

Chantada G, Fandiño A, Manzitti J, Urrutia L and Schvartzman E: Late diagnosis of retinoblastoma in a developing country. Arch Dis Child. 80:171–174. 1999. View Article : Google Scholar : PubMed/NCBI

11 

Schipper J, Tan KE and van Peperzeel HA: Treatment of retinoblastoma by precision megavoltage radiation therapy. Radiother Oncol. 3:117–132. 1985. View Article : Google Scholar : PubMed/NCBI

12 

Gallie BL, Budning A, DeBoer G, et al: Chemotherapy with focal therapy can cure intraocular retinoblastoma without radiotherapy. Arch Ophthalmol. 114:1321–1328. 1996. View Article : Google Scholar : PubMed/NCBI

13 

Kingston JE, Hungerford JL, Madreperla SA and Plowman PN: Results of combined chemotherapy and radiotherapy for advanced intraocular retinoblastoma. Arch Ophthalmol. 114:1339–1343. 1996. View Article : Google Scholar : PubMed/NCBI

14 

Veal GJ and Boddy AV: Carboplatin dosing in infants with retinoblastoma: a case for therapeutic drug monitoring. J Clin Oncol. 30:34242012. View Article : Google Scholar : PubMed/NCBI

15 

Rodriguez-Galindo C, Wilson MW, Haik BG, et al: Treatment of intraocular retinoblastoma with vincristine and carboplatin. J Clin Oncol. 21:2019–2025. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Varan A, Kiratli H, Aydin B, et al: The treatment of retinoblastoma with four-drug regimen including cisplatin, etoposide, vincristine, and cyclophosphamide. Pediatr Hematol Oncol. 29:529–537. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Chantada G, Fandino A, Casak S, Manzitti J, Raslawski E and Schvartzman E: Treatment of overt extraocular retinoblastoma. Med Pediatr Oncol. 40:158–161. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Gao YJ, Qian J, Yue H, Yuan YF, Xue K and Yao YQ: Clinical characteristics and treatment outcome of children with intraocular retinoblastoma: a report from a Chinese cooperative group. Pediatr Blood Cancer. 57:1113–1116. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Leahey A: A cautionary tale: dosing chemotherapy in infants with retinoblastoma. J Clin Oncol. 30:1023–1024. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Shields CL, Kaliki S, Shah SU, et al: Minimal exposure (one or two cycles) of intra-arterial chemotherapy in the management of retinoblastoma. Ophthalmology. 119:188–192. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Chan HS, Lu Y, Grogan TM, et al: Multidrug resistance protein (MRP) expression in retinoblastoma correlates with the rare failure of chemotherapy despite cyclosporine for reversal of P-glycoprotein. Cancer Res. 57:2325–2330. 1997.PubMed/NCBI

22 

Gobin YP, Dunkel IJ, Marr BP, Brodie SE and Abramson DH: Intra-arterial chemotherapy for the management of retinoblastoma: four-year experience. Arch Ophthalmol. 129:732–737. 2011.PubMed/NCBI

23 

Qaddoumi I, Bass JK, Wu J, et al: Carboplatin-associated ototoxicity in children with retinoblastoma. J Clin Oncol. 30:1034–1041. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Rizzuti AE, Dunkel IJ and Abramson DH: The adverse events of chemotherapy for retinoblastoma: What are they? Do we know? Arch Ophthalmol. 126:862–865. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Abramson DH, Lawrence SD, Beaverson KL, Lee TC, Rollins IS and Dunkel IJ: Systemic carboplatin for retinoblastoma: change in tumour size over time. Br J Ophthalmol. 89:1616–1619. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Marees T, van Leeuwen FE, de Boer MR, Imhof SM, Ringens PJ and Moll AC: Cancer mortality in long-term survivors of retinoblastoma. Eur J Cancer. 45:3245–3253. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Araki Y, Matsuyama Y, Kobayashi Y, et al: Secondary neoplasms after retinoblastoma treatment: retrospective cohort study of 754 patients in Japan. Jpn J Clin Oncol. 41:373–379. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Turaka K, Shields CL, Meadows AT and Leahey A: Second malignant neoplasms following chemoreduction with carboplatin, etoposide, and vincristine in 245 patients with intraocular retinoblastoma. Pediatr Blood Cancer. 59:121–125. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Tu Y: The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine. Nat Med. 17:1217–1220. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Balint G: Artemisinin and its derivatives: an important new class of antimalarial agents. Pharmacol Ther. 90:261–265. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Chaturvedi D, Goswami A, Saikia PP, Barua NC and Rao PG: Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents. Chem Soc Rev. 39:435–454. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Efferth T, Giaisi M, Merling A, Krammer PH and Li-Weber M: artesunate induces ROS-mediated apoptosis in doxorubicin-resistant T leukemia cells. PLoS One. 2:e6932007. View Article : Google Scholar : PubMed/NCBI

33 

Lai HC, Singh NP and Sasaki T: Development of artemisinin compounds for cancer treatment. Invest New Drugs. 31:230–246. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Gong Y, Gallis BM, Goodlett DR, et al: Effects of transferrin conjugates of artemisinin and artemisinin dimer on breast cancer cell lines. Anticancer Res. 33:123–132. 2013.PubMed/NCBI

35 

Gong XM, Zhang Q, Torossian A, Cao JP and Fu S: Selective radiosensitization of human cervical cancer cells and normal cells by artemisinin through the abrogation of radiation-induced G2 block. Int J Gynecol Cancer. 22:718–724. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Kerb R, Fux R, Mörike K, Kremsner PG, Gil JP, Gleiter CH and Schwab M: Pharmacogenetics of antimalarial drugs: effect on metabolism and transport. Lancet Infect Dis. 9:760–774. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Efferth T, Benakis A, Romero MR, et al: Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron. Free Radic Biol Med. 37:998–1009. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Berdelle N, Nikolova T, Quiros S, Efferth T and Kaina B: artesunate induces oxidative DNA damage, sustained DNA double-strand breaks, and the ATM/ATR damage response in cancer cells. Mol Cancer Ther. 10:2224–2233. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Li YSF, Wu JM, Wu GS, Ding J, Xiao D, Yang WY, Atassi G, Léonce S, Caignard DH and Renard P: Novel antitumor artemisinin derivatives targeting G1 phase of the cell cycle. Bioorg Med Chem Lett. 11:5–8. 2001. View Article : Google Scholar : PubMed/NCBI

40 

O’Neill PM, Barton VE and Ward SA: The molecular mechanism of action of artemisinin - the debate continues. Molecules. 15:1705–1721. 2010.PubMed/NCBI

41 

Hentze MW, Muckenthaler MU, Galy B and Camaschella C: Two to tango: regulation of Mammalian iron metabolism. Cell. 142:24–38. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Shpyleva SI, Tryndyak VP, Kovalchuk O, et al: Role of ferritin alterations in human breast cancer cells. Breast Cancer Res Treat. 126:63–71. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Richardson DR, Kalinowski DS, Lau S, Jansson PJ and Lovejoy DB: Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents. Biochim Biophys Acta. 1790:702–717. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Crespo-Ortiz MP and Wei MQ: Antitumor activity of artemisinin and its derivatives: from a well-known antimalarial agent to a potential anticancer drug. J Biomed Biotechnol. 2012:2475972012.PubMed/NCBI

45 

Altschul SF, Madden TL, Schäffer AA, Zhang J, Zhang Z, Miller W and Lipman DJ: Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25:3389–3402. 1997. View Article : Google Scholar : PubMed/NCBI

46 

Green MD, Mount DL, Wirtz RA and White NJ: A colorimetric field method to assess the authenticity of drugs sold as the antimalarial artesunate. J Pharm Biomed Anal. 24:65–70. 2000. View Article : Google Scholar : PubMed/NCBI

47 

Okwelogu C, Clark B, de Matas M, et al: Design of a fixed-dose paediatric combination of artesunate and amodiaquine hydrochloride. Int J Pharm. 387:19–25. 2010. View Article : Google Scholar : PubMed/NCBI

48 

Calvert AH, Newell DR, Gumbrell LA, et al: Carboplatin dosage: prospective evaluation of a simple formula based on renal function. J Clin Oncol. 7:1748–1756. 1989.PubMed/NCBI

49 

Shimokata T, Ando Y, Yasuda Y, et al: Prospective evaluation of pharmacokinetically guided dosing of carboplatin in Japanese patients with cancer. Cancer Sci. 101:2601–2605. 2010. View Article : Google Scholar : PubMed/NCBI

50 

Krishnakumar S, Mallikarjuna K, Desai N, et al: Multidrug resistant proteins: P-glycoprotein and lung resistance protein expression in retinoblastoma. Br J Ophthalmol. 88:1521–1526. 2004. View Article : Google Scholar : PubMed/NCBI

51 

Wilson MW, Fraga CH, Fuller CE, et al: Immunohistochemical detection of multidrug-resistant protein expression in retinoblastoma treated by primary enucleation. Invest Ophthalmol Vis Sci. 47:1269–1273. 2006. View Article : Google Scholar : PubMed/NCBI

52 

Deng DA, Xu CH and Cai JC: Derivatives of arteannuin B with antileukemia activity. Yao Xue Xue Bao. 27:317–320. 1992.(In Chinese).

53 

Sun WC, Han JX, Yang WY, Deng DA and Yue XF: Antitumor activities of 4 derivatives of artemisic acid and artemisinin B in vitro. Zhongguo Yao Li Xue Bao. 13:541–543. 1992.(In Chinese).

54 

Woerdenbag HJ, Moskal TA, Pras N, et al: Cytotoxicity of artemisinin-related endoperoxides to Ehrlich ascites tumor cells. J Nat Prod. 56:849–856. 1993. View Article : Google Scholar : PubMed/NCBI

55 

Yang XP, Pan QC, Ling YJ, et al: Study on antitumor effect of sodium artesunate. Cancer. 16:186–187. 1997.(In Chinese).

56 

Efferth T, Dunstan H, Sauerbrey A, Miyachi H and Chitambar CR: The anti-malarial artesunate is also active against cancer. Int J Oncol. 18:767–773. 2001.PubMed/NCBI

57 

Buommino E, Baroni A, Canozo N, et al: Artemisinin reduces human melanoma cell migration by down-regulating alpha V beta 3 integrin and reducing metalloproteinase 2 production. Invest New Drugs. 27:412–418. 2009. View Article : Google Scholar : PubMed/NCBI

58 

Morrissey C, Gallis B, Solazzi JW, et al: Effect of artemisinin derivatives on apoptosis and cell cycle in prostate cancer cells. Anticancer Drugs. 21:423–432. 2010. View Article : Google Scholar : PubMed/NCBI

59 

Du JH, Zhang HD, Ma ZJ and Ji KM: Artesunate induces oncosis-like cell death in vitro and has antitumor activity against pancreatic cancer xenografts in vivo. Cancer Chemother Pharmacol. 65:895–902. 2010. View Article : Google Scholar : PubMed/NCBI

60 

Efferth TSA, Olbrich A, Gebhart E, Rauch P, Weber HO, Hengstler JG, Halatsch ME, Volm M, Tew KD, Ross DD and Funk JO: Molecular modes of action of artesunate in tumor cell lines. Mol Pharmacol. 64:382–394. 2003. View Article : Google Scholar : PubMed/NCBI

61 

Singh NP and Verma KB: Case report of a laryngeal squamous cell carcinoma treated with artesunate. Arch Oncol. 10:279–280. 2002. View Article : Google Scholar

62 

Torti SV and Torti FM: Ironing out cancer. Cancer Res. 71:1511–1514. 2011. View Article : Google Scholar : PubMed/NCBI

63 

Shterman N, Kupfer B and Moroz C: Comparison of transferrin receptors, iron content and isoferritin profile in normal and malignant human breast cell lines. Pathobiology. 59:19–25. 1991. View Article : Google Scholar : PubMed/NCBI

64 

Daniels TR, Delgado T, Rodriguez JA, Helguera G and Penichet ML: The transferrin receptor part I: biology and targeting with cytotoxic antibodies for the treatment of cancer. Clin Immunol. 121:144–158. 2006. View Article : Google Scholar : PubMed/NCBI

65 

Daniels TR, Delgado T, Helguera G and Penichet ML: The transferrin receptor part II: targeted delivery of therapeutic agents into cancer cells. Clin Immunol. 121:159–176. 2006. View Article : Google Scholar : PubMed/NCBI

66 

Ba Q, Zhou N, Duan J, et al: Dihydroartemisinin exerts its anticancer activity through depleting cellular iron via transferrin receptor-1. PLoS One. 7:e427032012. View Article : Google Scholar : PubMed/NCBI

67 

Eichhorn T, Schloissnig S, Hahn B, et al: Bioinformatic and experimental fishing for artemisinin-interacting proteins from human nasopharyngeal cancer cells. Mol Biosyst. 8:1311–1318. 2012. View Article : Google Scholar : PubMed/NCBI

68 

Zhao Y, Jiang W, Li B, et al: Artesunate enhances radiosensitivity of human non-small cell lung cancer A549 cells via increasing NO production to induce cell cycle arrest at G2/M phase. Int Immunopharmacol. 11:2039–2046. 2011. View Article : Google Scholar : PubMed/NCBI

69 

Mercer AE, Maggs JL, Sun XM, et al: Evidence for the involvement of carbon-centered radicals in the induction of apoptotic cell death by artemisinin compounds. J Biol Chem. 282:9372–9382. 2007. View Article : Google Scholar : PubMed/NCBI

70 

Mercer AE, Copple IM, Maggs JL, O’Neill PM and Park BK: The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials. J Biol Chem. 286:987–996. 2011. View Article : Google Scholar : PubMed/NCBI

71 

Lai H and Singh NP: Selective cancer cell cytotoxicity from exposure to dihydroartemisinin and holotransferrin. Cancer Lett. 91:41–46. 1995. View Article : Google Scholar : PubMed/NCBI

72 

Lai H, Sasaki T and Singh NP: Targeted treatment of cancer with artemisinin and artemisinin-tagged iron-carrying compounds. Expert Opin Ther Targets. 9:995–1007. 2005. View Article : Google Scholar

73 

Nakase I, Lai H, Singh NP and Sasaki T: Anticancer properties of artemisinin derivatives and their targeted delivery by transferrin conjugation. Int J Pharm. 354:28–33. 2008. View Article : Google Scholar : PubMed/NCBI

74 

Kwok JC and Richardson DR: The iron metabolism of neoplastic cells: alterations that facilitate proliferation? Crit Rev Oncol Hematol. 42:65–78. 2002. View Article : Google Scholar : PubMed/NCBI

75 

Hamacher-Brady A, Stein HA, Turschner S, et al: Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production. J Biol Chem. 286:6587–6601. 2011. View Article : Google Scholar

76 

Krishna S, Bustamante L, Haynes RK and Staines HM: Artemisinins: their growing importance in medicine. Trends Pharmacol Sci. 29:520–527. 2008. View Article : Google Scholar

77 

Kelter G, Steinbach D, Konkimalla VB, et al: Role of transferrin receptor and the ABC transporters ABCB6 and ABCB7 for resistance and differentiation of tumor cells towards artesunate. PLoS One. 2:e7982007. View Article : Google Scholar : PubMed/NCBI

78 

Hartwig CL, Rosenthal AS, D’Angelo J, Griffin CE, Posner GH and Cooper RA: Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent. Biochem Pharmacol. 77:322–336. 2009. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhao F, Wang H, Kunda P, Chen X, Liu Q and Liu T: Artesunate exerts specific cytotoxicity in retinoblastoma cells via CD71. Oncol Rep 30: 1473-1482, 2013.
APA
Zhao, F., Wang, H., Kunda, P., Chen, X., Liu, Q., & Liu, T. (2013). Artesunate exerts specific cytotoxicity in retinoblastoma cells via CD71. Oncology Reports, 30, 1473-1482. https://doi.org/10.3892/or.2013.2574
MLA
Zhao, F., Wang, H., Kunda, P., Chen, X., Liu, Q., Liu, T."Artesunate exerts specific cytotoxicity in retinoblastoma cells via CD71". Oncology Reports 30.3 (2013): 1473-1482.
Chicago
Zhao, F., Wang, H., Kunda, P., Chen, X., Liu, Q., Liu, T."Artesunate exerts specific cytotoxicity in retinoblastoma cells via CD71". Oncology Reports 30, no. 3 (2013): 1473-1482. https://doi.org/10.3892/or.2013.2574
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao F, Wang H, Kunda P, Chen X, Liu Q and Liu T: Artesunate exerts specific cytotoxicity in retinoblastoma cells via CD71. Oncol Rep 30: 1473-1482, 2013.
APA
Zhao, F., Wang, H., Kunda, P., Chen, X., Liu, Q., & Liu, T. (2013). Artesunate exerts specific cytotoxicity in retinoblastoma cells via CD71. Oncology Reports, 30, 1473-1482. https://doi.org/10.3892/or.2013.2574
MLA
Zhao, F., Wang, H., Kunda, P., Chen, X., Liu, Q., Liu, T."Artesunate exerts specific cytotoxicity in retinoblastoma cells via CD71". Oncology Reports 30.3 (2013): 1473-1482.
Chicago
Zhao, F., Wang, H., Kunda, P., Chen, X., Liu, Q., Liu, T."Artesunate exerts specific cytotoxicity in retinoblastoma cells via CD71". Oncology Reports 30, no. 3 (2013): 1473-1482. https://doi.org/10.3892/or.2013.2574
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team