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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 2013 Volume 30 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

miR-21 and its target gene CCL20 are both highly overexpressed in the microenvironment of colorectal tumors: Significance of their regulation

  • Authors:
    • Benjamin Vicinus
    • Claudia Rubie
    • Nathalie Stegmaier
    • Vilma Oliveira Frick
    • Kathrin Kölsch
    • Anne Kauffels
    • Pirus Ghadjar
    • Mathias  Wagner
    • Matthias Glanemann

  • View Affiliations / Copyright

    Affiliations: Department of General, Visceral, Vascular and Paediatric Surgery, University of the Saarland, 66421 Homburg/Saar, Germany, Department of Radiation Oncology, Inselspital, Bern University Hospital and University of Bern, 3010 Bern, Switzerland, Institute of Pathology, University of the Saarland, 66421 Homburg/Saar, Germany
  • Pages: 1285-1292
    |
    Published online on: July 1, 2013
       https://doi.org/10.3892/or.2013.2580
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Abstract

Recently, we reported a functional interaction between miR-21 and its identified chemokine target CCL20 in colorectal cancer (CRC) cell lines. Here, we investigated whether such functional interactions are permitted at the cellular level which would require an inverse correlation of expression and also co-expression of miR-21 and CCL20 in the same cell. Expression profiling was performed using qPCR, and ELISA, in situ hybridization and immunohistochemistry were applied for the presentation of their cellular localization. We demonstrated that miR-21 as well as CCL20 were both significantly upregulated in CRC tissues; thus, showing no antidromic expression pattern. This provided an initial clue that miR-21 and CCL20 may not be expressed in the same cell. In addition, we located miR-21 expression at the cellular level predominantly in stromal cells such as tumor-associated fibroblasts and to a minor degree in immune cells such as macrophages and lymphocytes. Likewise, CCL20 expression was primarily detected in tumor-infiltrating immune cells. Thus, investigating the cellular localization of miR-21 and its target CCL20 revealed that both molecules are expressed predominantly in the microenvironment of CRC tumors.

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Copy and paste a formatted citation
Spandidos Publications style
Vicinus B, Rubie C, Stegmaier N, Frick VO, Kölsch K, Kauffels A, Ghadjar P, Wagner M and Glanemann M: miR-21 and its target gene CCL20 are both highly overexpressed in the microenvironment of colorectal tumors: Significance of their regulation. Oncol Rep 30: 1285-1292, 2013.
APA
Vicinus, B., Rubie, C., Stegmaier, N., Frick, V.O., Kölsch, K., Kauffels, A. ... Glanemann, M. (2013). miR-21 and its target gene CCL20 are both highly overexpressed in the microenvironment of colorectal tumors: Significance of their regulation. Oncology Reports, 30, 1285-1292. https://doi.org/10.3892/or.2013.2580
MLA
Vicinus, B., Rubie, C., Stegmaier, N., Frick, V. O., Kölsch, K., Kauffels, A., Ghadjar, P., Wagner, M., Glanemann, M."miR-21 and its target gene CCL20 are both highly overexpressed in the microenvironment of colorectal tumors: Significance of their regulation". Oncology Reports 30.3 (2013): 1285-1292.
Chicago
Vicinus, B., Rubie, C., Stegmaier, N., Frick, V. O., Kölsch, K., Kauffels, A., Ghadjar, P., Wagner, M., Glanemann, M."miR-21 and its target gene CCL20 are both highly overexpressed in the microenvironment of colorectal tumors: Significance of their regulation". Oncology Reports 30, no. 3 (2013): 1285-1292. https://doi.org/10.3892/or.2013.2580
Copy and paste a formatted citation
x
Spandidos Publications style
Vicinus B, Rubie C, Stegmaier N, Frick VO, Kölsch K, Kauffels A, Ghadjar P, Wagner M and Glanemann M: miR-21 and its target gene CCL20 are both highly overexpressed in the microenvironment of colorectal tumors: Significance of their regulation. Oncol Rep 30: 1285-1292, 2013.
APA
Vicinus, B., Rubie, C., Stegmaier, N., Frick, V.O., Kölsch, K., Kauffels, A. ... Glanemann, M. (2013). miR-21 and its target gene CCL20 are both highly overexpressed in the microenvironment of colorectal tumors: Significance of their regulation. Oncology Reports, 30, 1285-1292. https://doi.org/10.3892/or.2013.2580
MLA
Vicinus, B., Rubie, C., Stegmaier, N., Frick, V. O., Kölsch, K., Kauffels, A., Ghadjar, P., Wagner, M., Glanemann, M."miR-21 and its target gene CCL20 are both highly overexpressed in the microenvironment of colorectal tumors: Significance of their regulation". Oncology Reports 30.3 (2013): 1285-1292.
Chicago
Vicinus, B., Rubie, C., Stegmaier, N., Frick, V. O., Kölsch, K., Kauffels, A., Ghadjar, P., Wagner, M., Glanemann, M."miR-21 and its target gene CCL20 are both highly overexpressed in the microenvironment of colorectal tumors: Significance of their regulation". Oncology Reports 30, no. 3 (2013): 1285-1292. https://doi.org/10.3892/or.2013.2580
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