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Article

Patrinia scabiosaefolia inhibits colorectal cancer growth through suppression of tumor angiogenesis

  • Authors:
    • Liwu Chen
    • Liya Liu
    • Ling Ye
    • Aling Shen
    • Youqin Chen
    • Thomas J. Sferra
    • Jun  Peng
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350003, P.R. China, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China, Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
  • Pages: 1439-1443
    |
    Published online on: July 2, 2013
       https://doi.org/10.3892/or.2013.2582
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Abstract

Angiogenesis is an essential process for tumor development and metastasis, therefore inhibition of tumor angiogenesis has become a promising strategy for anticancer treatments. Patrinia scabiosaefolia, a well-known Oriental folk medicine, has been shown to be effective in the clinical treatment of gastrointestinal cancers. However, the precise mechanism of its tumoricidal activity remains largely unknown. Using a colorectal cancer (CRC) mouse xenograft model, the human colon carcinoma cell line HT-29 and human umbilical vein endothelial cells (HUVECs), in the present study we evaluated the effects of an ethanol extract of Patrinia scabiosaefolia (EEPS) on tumor angiogenesis in vivo and in vitro, and investigated the underlying molecular mechanisms. We found that EEPS treatment significantly reduced the tumor volume in CRC mice and decreased the intratumoral microvessel density in tumor tissues. In addition, EEPS inhibited several key processes of angiogenesis, including the proliferation, migration and tube formation of HUVECs. Moreover, EEPS treatment suppressed the expression of VEGF-A in CRC tumors and HT-29 cells. Collectively, our data suggest that Patrinia scabiosaefolia inhibits CRC growth likely via suppression of tumor angiogenesis.
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Copy and paste a formatted citation
Spandidos Publications style
Chen L, Liu L, Ye L, Shen A, Chen Y, Sferra TJ and Peng J: Patrinia scabiosaefolia inhibits colorectal cancer growth through suppression of tumor angiogenesis. Oncol Rep 30: 1439-1443, 2013.
APA
Chen, L., Liu, L., Ye, L., Shen, A., Chen, Y., Sferra, T.J., & Peng, J. (2013). Patrinia scabiosaefolia inhibits colorectal cancer growth through suppression of tumor angiogenesis. Oncology Reports, 30, 1439-1443. https://doi.org/10.3892/or.2013.2582
MLA
Chen, L., Liu, L., Ye, L., Shen, A., Chen, Y., Sferra, T. J., Peng, J."Patrinia scabiosaefolia inhibits colorectal cancer growth through suppression of tumor angiogenesis". Oncology Reports 30.3 (2013): 1439-1443.
Chicago
Chen, L., Liu, L., Ye, L., Shen, A., Chen, Y., Sferra, T. J., Peng, J."Patrinia scabiosaefolia inhibits colorectal cancer growth through suppression of tumor angiogenesis". Oncology Reports 30, no. 3 (2013): 1439-1443. https://doi.org/10.3892/or.2013.2582
Copy and paste a formatted citation
x
Spandidos Publications style
Chen L, Liu L, Ye L, Shen A, Chen Y, Sferra TJ and Peng J: Patrinia scabiosaefolia inhibits colorectal cancer growth through suppression of tumor angiogenesis. Oncol Rep 30: 1439-1443, 2013.
APA
Chen, L., Liu, L., Ye, L., Shen, A., Chen, Y., Sferra, T.J., & Peng, J. (2013). Patrinia scabiosaefolia inhibits colorectal cancer growth through suppression of tumor angiogenesis. Oncology Reports, 30, 1439-1443. https://doi.org/10.3892/or.2013.2582
MLA
Chen, L., Liu, L., Ye, L., Shen, A., Chen, Y., Sferra, T. J., Peng, J."Patrinia scabiosaefolia inhibits colorectal cancer growth through suppression of tumor angiogenesis". Oncology Reports 30.3 (2013): 1439-1443.
Chicago
Chen, L., Liu, L., Ye, L., Shen, A., Chen, Y., Sferra, T. J., Peng, J."Patrinia scabiosaefolia inhibits colorectal cancer growth through suppression of tumor angiogenesis". Oncology Reports 30, no. 3 (2013): 1439-1443. https://doi.org/10.3892/or.2013.2582
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