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Article

EtBr-induced selective degradation of mitochondria occurs via autophagy

  • Authors:
    • Yan Luo
    • Yide Hu
    • Minghui Zhang
    • Yu Xiao
    • Zongchang Song
    • Yu Xu
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The Second Affiliated Hospital, Third Military Medical University, Chongqing 400037, P.R. China
  • Pages: 1201-1208
    |
    Published online on: July 4, 2013
       https://doi.org/10.3892/or.2013.2590
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Abstract

Recent studies have implicated autophagy in numerous cellular responses to stress. During the establishment of human lung cancer cell lines without mitochondrial DNA, a significant depopulation of mitochondria occurred that was accompanied by the loss of the mitochondrial membrane potential. Notably, we observed autophagy in ethidium bromide (EtBr)-induced mitochondrial degradation. In the present study, we confirmed the involvement of autophagy in mitochondrial degradation after exposure to a low concentration of EtBr. Lung cancer cells undergoing mitochondrial autophagy exhibited a slower growth rate in vitro and in vivo. Furthermore, the degradation was mediated by the class III phosphatidylinositol 3-kinase (PI3K)-Beclin-1 complex. These findings indicate that autophagy is responsible for EtBr‑induced mitochondrial degradation via the PI3K‑Beclin-1 signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Luo Y, Hu Y, Zhang M, Xiao Y, Song Z and Xu Y: EtBr-induced selective degradation of mitochondria occurs via autophagy. Oncol Rep 30: 1201-1208, 2013.
APA
Luo, Y., Hu, Y., Zhang, M., Xiao, Y., Song, Z., & Xu, Y. (2013). EtBr-induced selective degradation of mitochondria occurs via autophagy. Oncology Reports, 30, 1201-1208. https://doi.org/10.3892/or.2013.2590
MLA
Luo, Y., Hu, Y., Zhang, M., Xiao, Y., Song, Z., Xu, Y."EtBr-induced selective degradation of mitochondria occurs via autophagy". Oncology Reports 30.3 (2013): 1201-1208.
Chicago
Luo, Y., Hu, Y., Zhang, M., Xiao, Y., Song, Z., Xu, Y."EtBr-induced selective degradation of mitochondria occurs via autophagy". Oncology Reports 30, no. 3 (2013): 1201-1208. https://doi.org/10.3892/or.2013.2590
Copy and paste a formatted citation
x
Spandidos Publications style
Luo Y, Hu Y, Zhang M, Xiao Y, Song Z and Xu Y: EtBr-induced selective degradation of mitochondria occurs via autophagy. Oncol Rep 30: 1201-1208, 2013.
APA
Luo, Y., Hu, Y., Zhang, M., Xiao, Y., Song, Z., & Xu, Y. (2013). EtBr-induced selective degradation of mitochondria occurs via autophagy. Oncology Reports, 30, 1201-1208. https://doi.org/10.3892/or.2013.2590
MLA
Luo, Y., Hu, Y., Zhang, M., Xiao, Y., Song, Z., Xu, Y."EtBr-induced selective degradation of mitochondria occurs via autophagy". Oncology Reports 30.3 (2013): 1201-1208.
Chicago
Luo, Y., Hu, Y., Zhang, M., Xiao, Y., Song, Z., Xu, Y."EtBr-induced selective degradation of mitochondria occurs via autophagy". Oncology Reports 30, no. 3 (2013): 1201-1208. https://doi.org/10.3892/or.2013.2590
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