Open Access

Evaluation of eligibility criteria in living donor liver transplantation for hepatocellular carcinoma by α-SMA-positive cancer-associated fibroblasts

  • Authors:
    • Hiroyuki Takamura
    • Shinichi Nakanuma
    • Hironori Hayashi
    • Hidehiro Tajima
    • Kaheita Kakinoki
    • Seisyo Sakai
    • Isamu Makino
    • Hisatoshi Nakagawara
    • Tomoharu Miyashita
    • Koichi Okamoto
    • Keishi Nakamura
    • Katunobu Oyama
    • Masashi Inokuchi
    • Itasu Ninomiya
    • Hirohisa Kitagawa
    • Sachio Fushida
    • Takashi Fujimura
    • Ichiro Ohnishi
    • Masato Kayahara
    • Takashi Tani
    • Kuniaki Arai
    • Taro Yamashita
    • Tatsuya Yamashita
    • Hoshiko Kitamura
    • Hiroko Ikeda
    • Shuichi Kaneko
    • Yasuni Nakanuma
    • Osamu Matsui
    • Tetsuo Ohta
  • View Affiliations

  • Published online on: July 16, 2013     https://doi.org/10.3892/or.2013.2616
  • Pages: 1561-1574
  • Copyright: © Takamura et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

The eligibility criteria of liver transplantation (LT) for hepatocellular carcinoma (HCC) must clearly confirm the prognosis not only from pathological diagnosis but also from pre-operative imaging diagnosis. In the present study, we evaluated published eligibility criteria for LT based on both pre-operative imaging diagnosis and pathological diagnosis using living donor liver transplantation (LDLT) recipients at our hospital by α-smooth muscle actin (SMA)-positive cancer‑associated fibroblasts (CAFs) in HCC. The Up-to-seven (Up‑to‑7), Asan and Tokyo criteria were evaluated, in both overall survival and HCC disease‑free survival, to be statistically significantly beneficial criteria to define post-LDLT prognosis. Recipients only within Up‑to‑7 criteria based on both pre-operative imaging diagnosis and pathological diagnosis survived without HCC recurrence. Recipients with proliferation of α-SMA‑positive CAFs in HCC had significantly poorer prognosis. All survival recipients without HCC recurrence, who were above the Up‑to‑7 criteria in pathological diagnosis, had no proliferation of α-SMA-positive CAFs. As a result of multivariate analysis, the significant independent factors defining prognosis of recipients after LDLT for HCC were Up‑to‑7 criteria and proliferation of α-SMA-positive CAFs. The ideal eligibility criteria for LDLT with HCC is Up‑to‑7 criteria and α-SMA-positive CAFs was considered to be an important factor in HCC recurrence. LDLT should be limited to recipients within Up‑to‑7 criteria or without proliferation of α-SMA-positive CAFs.
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October 2013
Volume 30 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Takamura H, Nakanuma S, Hayashi H, Tajima H, Kakinoki K, Sakai S, Makino I, Nakagawara H, Miyashita T, Okamoto K, Okamoto K, et al: Evaluation of eligibility criteria in living donor liver transplantation for hepatocellular carcinoma by α-SMA-positive cancer-associated fibroblasts. Oncol Rep 30: 1561-1574, 2013
APA
Takamura, H., Nakanuma, S., Hayashi, H., Tajima, H., Kakinoki, K., Sakai, S. ... Ohta, T. (2013). Evaluation of eligibility criteria in living donor liver transplantation for hepatocellular carcinoma by α-SMA-positive cancer-associated fibroblasts. Oncology Reports, 30, 1561-1574. https://doi.org/10.3892/or.2013.2616
MLA
Takamura, H., Nakanuma, S., Hayashi, H., Tajima, H., Kakinoki, K., Sakai, S., Makino, I., Nakagawara, H., Miyashita, T., Okamoto, K., Nakamura, K., Oyama, K., Inokuchi, M., Ninomiya, I., Kitagawa, H., Fushida, S., Fujimura, T., Ohnishi, I., Kayahara, M., Tani, T., Arai, K., Yamashita, T., Yamashita, T., Kitamura, H., Ikeda, H., Kaneko, S., Nakanuma, Y., Matsui, O., Ohta, T."Evaluation of eligibility criteria in living donor liver transplantation for hepatocellular carcinoma by α-SMA-positive cancer-associated fibroblasts". Oncology Reports 30.4 (2013): 1561-1574.
Chicago
Takamura, H., Nakanuma, S., Hayashi, H., Tajima, H., Kakinoki, K., Sakai, S., Makino, I., Nakagawara, H., Miyashita, T., Okamoto, K., Nakamura, K., Oyama, K., Inokuchi, M., Ninomiya, I., Kitagawa, H., Fushida, S., Fujimura, T., Ohnishi, I., Kayahara, M., Tani, T., Arai, K., Yamashita, T., Yamashita, T., Kitamura, H., Ikeda, H., Kaneko, S., Nakanuma, Y., Matsui, O., Ohta, T."Evaluation of eligibility criteria in living donor liver transplantation for hepatocellular carcinoma by α-SMA-positive cancer-associated fibroblasts". Oncology Reports 30, no. 4 (2013): 1561-1574. https://doi.org/10.3892/or.2013.2616