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Article

Modulation of the response of prostate cancer cell lines to cisplatin treatment using small interfering RNA

  • Authors:
    • Eduardo Parra
    • Jorge Ferreira
  • View Affiliations / Copyright

    Affiliations: Laboratory of Experimental Biomedicine, University of Tarapaca, Campus Esmeralda, Iquique, Chile, Programme of Molecular and Clinical Pharmacology, ICBM, Medical Faculty, University of Chile, Independencia, Santiago, Chile
  • Pages: 1936-1942
    |
    Published online on: July 24, 2013
       https://doi.org/10.3892/or.2013.2637
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Abstract

Cisplatin is one of the most effective and widely used chemotherapeutic agents against several types of human cancers. However, the underlying mechanisms of action are not fully understood. We aimed to investigate the possible molecular mechanism(s) of acquired chemoresistance observed in prostate cancer cells treated with cisplatin. Human LNCaP cells (bearing wild-type p53) and PC-3 cells (lacking p53) were used. The expression levels of protein were determined by western blotting, and the mRNA levels were determined by reverse transcription-polymerase chain reaction (RT-PCR). Cell viability was measured by MTT assay, and the transcriptional effect of small interfering RNA (siRNA) was measured by luciferase reporter gene. We showed that cisplatin treatment increased JNK-1 and JNK-2 activity and expression in both LNCaP and PC-3 cells. In addition, the knockdown of JNK-1 expression by siRNA-JNK-1 or siRNA-JNK-2 significantly impaired the upregulation of AP-1 luciferase reporter gene, but failed to decrease the levels of AP-1 reporter gene expression induced by TPA treatment. Our observations indicate that JNK-1 and JNK-2 may be involved in the chemoresistance observed in prostate cancer cells treated with cisplatin and that blocking the stimulation of Jun kinase (JNK) signaling may be important for regulating the susceptibility to cisplatin of prostate cancer.
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1 

Davis RJ: Signal transduction by the JNK group of MAP kinases. Cell. 103:239–252. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Kralova J, Sheely JI, Liss AS and Bose HR Jr: ERK and JNK activation is essential for oncogenic transformation by v-Rel. Oncogene. 29:6267–6279. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Binétruy B, Smeal T and Karin M: Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. Nature. 351:122–127. 1991.PubMed/NCBI

4 

Smeal T, Binétruy B, Mercola DA, Birrer M and Karin M: Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73. Nature. 354:494–496. 1991. View Article : Google Scholar : PubMed/NCBI

5 

Mechta F, Lallemand D, Pfarr CM and Yaniv M: Transformation by ras modifies AP1 composition and activity. Oncogene. 14:837–847. 1997. View Article : Google Scholar : PubMed/NCBI

6 

Minden A and Karin M: Regulation and function of the JNK subgroup of MAP kinases. Biochim Biophys Acta. 1333:F85–F104. 1997.PubMed/NCBI

7 

Verheij M, Ruiter GA, Zerp SF, van Blitterswijk WJ, Fuks Z, Haimovitz-Friedman A and Bartelink H: The role of the stress-activated protein kinase (SAPK/JNK) signaling pathway in radiation-induced apoptosis. Radiother Oncol. 47:225–232. 1998. View Article : Google Scholar : PubMed/NCBI

8 

Paul A, Wilson S, Belham CM, Robinson CJ, Scott PH, Gould GW and Plevin R: Stress-activated protein kinases: activation, regulation and function. Cell Signal. 9:403–410. 1997. View Article : Google Scholar : PubMed/NCBI

9 

Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, Dérijard B and Davis RJ: Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J. 15:2760–2770. 1996.PubMed/NCBI

10 

Adler V, Fuchs SY, Kim J, Kraft A, King MP, Pelling J and Ronai Z: jun-NH2-terminal kinase activation mediated by UV-induced DNA lesions in melanoma and fibroblast cells. Cell Growth Differ. 6:1437–1446. 1995.

11 

Amdjadi K and Sefton BM: Ultraviolet light-induced stimulation of the JNK mitogen-activated protein kinase in the absence of src family tyrosine kinase activation. J Biol Chem. 275:22520–22525. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Potapova O, Haghighi A, Bost F, Liu C, Birrer MJ, Gjerset R and Mercola D: The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin. J Biol Chem. 272:14041–14044. 1997. View Article : Google Scholar : PubMed/NCBI

13 

Saleem A, Datta R, Yuan ZM, Kharbanda S and Kufe D: Involvement of stress-activated protein kinase in the cellular response to 1-β-D-arabinofuranosylcytosine and other DNA-damaging agents. Cell Growth Differ. 6:1651–1658. 1995.

14 

Osborn MT and Chambers TC: Role of the stress-activated/c-Jun NH2-terminal protein kinase pathway in the cellular response to adriamycin and other chemotherapeutic drugs. J Biol Chem. 271:30950–30955. 1996.PubMed/NCBI

15 

Hashimoto A, Kurosaki M, Gotoh N, Shibuya M and Kurosaki T: Shc regulates epidermal growth factor-induced activation of the JNK signaling pathway. J Biol Chem. 274:20139–20143. 1999. View Article : Google Scholar : PubMed/NCBI

16 

Bost F, McKay R, Dean N and Mercola D: The JUN kinase/stress-activated protein kinase pathway is required for epidermal growth factor stimulation of growth of human A549 lung carcinoma cells. J Biol Chem. 272:33422–33429. 1997. View Article : Google Scholar : PubMed/NCBI

17 

Kang SA, Lee ES, Yoon HY, Randazzo PA and Lee ST: PTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1. J Biol Chem. 285:26013–26021. 2010. View Article : Google Scholar : PubMed/NCBI

18 

van Dam H, Wilhelm D, Herr I, Steffen A, Herrlich P and Angel P: ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. EMBO J. 14:1798–1811. 1995.PubMed/NCBI

19 

Pulverer BJ, Kyriakis JM, Avruch J, Nikolakaki E and Woodgett JR: Phosphorylation of c-jun mediated by MAP kinases. Nature. 353:670–674. 1991. View Article : Google Scholar : PubMed/NCBI

20 

Tanabe M, Izumi H, Ise T, Higuchi S, Yamori T, Yasumoto K and Kohno K: Activating transcription factor 4 increases the cisplatin resistance of human cancer cell lines. Cancer Res. 63:8592–8595. 2003.PubMed/NCBI

21 

Crul M, Schellens JH, Beijnen JH and Maliepaard M: Cisplatin resistance and DNA repair. Cancer Treat Rev. 23:341–366. 1997. View Article : Google Scholar : PubMed/NCBI

22 

Parra E and Ferreira J: Knockdown of the c-Jun-N-terminal kinase expression by siRNA inhibits MCF-7 breast carcinoma cell line growth. Oncol Rep. 24:1339–1345. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Tsuiki H, Tnani M, Okamoto I, Kenyon LC, Emlet DR, Holgado-Madruga M, Lanham IS, et al: Constitutively active forms of c-Jun NH2-terminal kinase are expressed in primary glial tumors. Cancer Res. 63:250–255. 2003.PubMed/NCBI

24 

Vivas-Mejia P, Benito JM, Fernandez A, Han HD, Mangala L, Rodriguez-Aguayo C, et al: c-Jun-NH2-kinase-1 inhibition leads to antitumor activity in ovarian cancer. Clin Cancer Res. 16:184–194. 2010.

25 

Lovejoy KS, Todd RC, Zhang S, McCormick MS, D’Aquino JA, Reardon JT, Sancar A, Giacomini KM and Lippard SJ: cis-Diammine (pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: uptake, structure, function, and prospects. Proc Natl Acad Sci USA. 105:8902–8907. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Levresse V, Marek L, Blumberg D and Heasley LE: Regulation of platinum-compound cytotoxicity by the c-Jun N-terminal kinase and c-Jun signaling pathway in small-cell lung cancer cells. Mol Pharmacol. 62:689–697. 2002. View Article : Google Scholar : PubMed/NCBI

27 

Helbig L, Damrot J, Hülsenbeck J, Köberle B, Brozovic A, Osmak M, Fiket Z, Kaina B and Fritz G: Late activation of stress-activated protein kinases/c-Jun N-terminal kinases triggered by cisplatin-induced DNA damage in repair-defective cells. J Biol Chem. 286:12991–13001. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Fritz G and Kaina B: Late activation of stress kinases (SAPK/JNK) by genotoxins requires the DNA repair proteins DNA-PKcs and CSB. Mol Biol Cell. 17:851–861. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Brozovic A, Fritz G, Christmann M, Zisowsky J, Jaehde U, Osmak M and Kaina B: Long-term activation of SAPK/JNK, p38 kinase and fas-L expression by cisplatin is attenuated in human carcinoma cells that acquired drug resistance. Int J Cancer. 112:974–985. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Hayakawa J, Depatie C, Ohmichi M and Mercola D: The activation of c-Jun NH2-terminal kinase (JNK) by DNA-damaging agents serves to promote drug resistance via activating transcription factor 2 (ATF2)-dependent enhanced DNA repair. J Biol Chem. 278:20582–20592. 2003.

31 

Smeal T, Binetruy B, Mercola D, Grover-Bardwick A, Heidecker G, Rapp UR and Karin M: Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73. Mol Cell Biol. 12:3507–3513. 1992.PubMed/NCBI

32 

Boyle WJ, Smeal T, Defize LH, Angel P, Woodgett JR, Karin M and Hunter T: Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. Cell. 64:573–584. 1991. View Article : Google Scholar : PubMed/NCBI

33 

Parra E, Ortega A and Saenz L: Down-regulation of Egr-1 by siRNA inhibits growth of human prostate carcinoma cell line PC-3. Oncol Rep. 22:1513–1518. 2009.PubMed/NCBI

34 

Parra E, Ferreira F and Saenz L: Inhibition of Egr-1 by siRNA in prostate carcinoma cell lines is associated with decreased expression of AP-1 and NF-κB. Int J Mol Med. 28:847–853. 2011.PubMed/NCBI

35 

Parra E, Ferreira J and Ortega A: Overexpression of EGR-1 modulates the activity of NF-κB and AP-1 in prostate carcinoma PC-3 and LNCaP cell lines. Int J Oncol. 39:345–352. 2011.PubMed/NCBI

36 

Inostroza J, Sáenz L, Calaf G, Cabello G and Parra E: Role of the phosphatase PP4 in the activation of JNK-1 in prostate carcinoma cell lines PC-3 and LNCaP resulting in increased AP-1 and EGR-1 activity. Biol Res. 38:163–178. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Yu JJ, Li Q and Reed E: Comparison of two human ovarian carcinoma cell lines (A2780/CP70 and MCAS) that are equally resistant to platinum, but differ at codon 118 of the ERCC1 gene. Int J Oncol. 16:555–560. 2000.PubMed/NCBI

38 

Ma FY, Flanc RS, Tesch GH, Han Y, Atkins RC, Bennett BL, Friedman GC, Fan JH and Nikolic-Paterson DJ: A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis. J Am Soc Nephrol. 18:472–484. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Vivanco I, Palaskas N, Tran C, Finn SP, Getz G, Kennedy NJ, Jiao J, Rose J, Xie W, Loda M, et al: Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN. Cancer Cell. 11:555–569. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Cellurale C, Girnius N, Jiang F, Cavanagh-Kyros J, Lu S, Garlick DS, Mercurio AM and Davis RJ: Role of JNK in mammary gland development and breast cancer. Cancer Res. 72:472–481. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Burgess GS, Williamson EA, Cripe LD, Litz-Jackson S, Bhatt JA, Stanley K, Stewart MJ, Kraft AS, Nakshatri H and Boswell HS: Regulation of the c-jun gene in p210 BCR-ABL transformed cells corresponds with activity of JNK, the c-jun N-terminal kinase. Blood. 92:2450–2460. 1998.PubMed/NCBI

42 

Raitano AB, Halpern JR, Hambuch TM and Sawyers CL: The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation. Proc Natl Acad Sci USA. 92:11746–11750. 1995. View Article : Google Scholar : PubMed/NCBI

43 

Wagner EF and Nebreda AR: Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer. 9:537–549. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Liu J, Minemoto Y and Lin A: c-Jun N-terminal protein kinase 1 (JNK1), but not JNK2, is essential for tumor necrosis factor alpha-induced c-Jun kinase activation and apoptosis. Mol Cell Biol. 24:10844–10856. 2004. View Article : Google Scholar : PubMed/NCBI

45 

Hayakawa J, Mittal S, Wang Y, Korkmaz KS, Adamson E, English C, Ohmichi M, McClelland M and Mercola D: Identification of promoters bound by c-Jun/ATF2 during rapid large-scale gene activation following genotoxic stress. Mol Cell. 16:521–535. 2004. View Article : Google Scholar : PubMed/NCBI

46 

Halazonetis TD, Georgopoulos K, Greenberg ME and Leder P: c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities. Cell. 55:917–924. 1988. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Parra E and Ferreira J: Modulation of the response of prostate cancer cell lines to cisplatin treatment using small interfering RNA. Oncol Rep 30: 1936-1942, 2013.
APA
Parra, E., & Ferreira, J. (2013). Modulation of the response of prostate cancer cell lines to cisplatin treatment using small interfering RNA. Oncology Reports, 30, 1936-1942. https://doi.org/10.3892/or.2013.2637
MLA
Parra, E., Ferreira, J."Modulation of the response of prostate cancer cell lines to cisplatin treatment using small interfering RNA". Oncology Reports 30.4 (2013): 1936-1942.
Chicago
Parra, E., Ferreira, J."Modulation of the response of prostate cancer cell lines to cisplatin treatment using small interfering RNA". Oncology Reports 30, no. 4 (2013): 1936-1942. https://doi.org/10.3892/or.2013.2637
Copy and paste a formatted citation
x
Spandidos Publications style
Parra E and Ferreira J: Modulation of the response of prostate cancer cell lines to cisplatin treatment using small interfering RNA. Oncol Rep 30: 1936-1942, 2013.
APA
Parra, E., & Ferreira, J. (2013). Modulation of the response of prostate cancer cell lines to cisplatin treatment using small interfering RNA. Oncology Reports, 30, 1936-1942. https://doi.org/10.3892/or.2013.2637
MLA
Parra, E., Ferreira, J."Modulation of the response of prostate cancer cell lines to cisplatin treatment using small interfering RNA". Oncology Reports 30.4 (2013): 1936-1942.
Chicago
Parra, E., Ferreira, J."Modulation of the response of prostate cancer cell lines to cisplatin treatment using small interfering RNA". Oncology Reports 30, no. 4 (2013): 1936-1942. https://doi.org/10.3892/or.2013.2637
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