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Article

CD176 antiserum treatment leads to a therapeutic response in a murine model of leukemia

  • Authors:
    • Bin Yi
    • Zhe Zhang
    • Min Zhang
    • Reinhard Schwartz-Albiez
    • Yi Cao
  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular and Experimental Pathology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, P.R. China, Translational Immunology Unit, German Cancer Research Center, Heidelberg, Germany
  • Pages: 1841-1847
    |
    Published online on: July 25, 2013
       https://doi.org/10.3892/or.2013.2639
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Abstract

CD176 (Thomsen-Friedenreich antigen) is a tumor-associated carbohydrate structure. CD176 is expressed at the surface of human leukemic cells but is almost absent in normal and benign adult human tissues. Therefore, CD176 could be a promising target for antitumor immunotherapy. In the present study, pre-immunization with asialoglycophorin A (containing the CD176 oligosaccharide chains) was able to significantly improve the survival time of mice carrying CD176+ leukemia as compared to the control mice without the immunization. Furthermore, the passive transfer of CD176 antiserum which reacted only with the tumor-associated CD176 in cancer cells, was able to effectively prolong the survival time of CD176+ leukemia mice. In particular, the CD176 antiserum treatment could inhibit the growth and spreading of CD176+ leukemic cells in bone marrow, spleen, liver, and lung as evidenced by histopathological examination. CD176 antiserum could induce the apoptosis of CD176+ leukemic cells in vivo in a manner as previously observed in vitro. The data provided strong evidence that both CD176 antigen-based active immunotherapy and CD176 antibody-based passive immunotherapy lead to a therapeutic response in CD176+ leukemia mice. Therefore, both CD176 vaccine and CD176 antibody drug may be beneficial for the treatment of CD176+ leukemia patients.
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Copy and paste a formatted citation
Spandidos Publications style
Yi B, Zhang Z, Zhang M, Schwartz-Albiez R and Cao Y: CD176 antiserum treatment leads to a therapeutic response in a murine model of leukemia. Oncol Rep 30: 1841-1847, 2013.
APA
Yi, B., Zhang, Z., Zhang, M., Schwartz-Albiez, R., & Cao, Y. (2013). CD176 antiserum treatment leads to a therapeutic response in a murine model of leukemia. Oncology Reports, 30, 1841-1847. https://doi.org/10.3892/or.2013.2639
MLA
Yi, B., Zhang, Z., Zhang, M., Schwartz-Albiez, R., Cao, Y."CD176 antiserum treatment leads to a therapeutic response in a murine model of leukemia". Oncology Reports 30.4 (2013): 1841-1847.
Chicago
Yi, B., Zhang, Z., Zhang, M., Schwartz-Albiez, R., Cao, Y."CD176 antiserum treatment leads to a therapeutic response in a murine model of leukemia". Oncology Reports 30, no. 4 (2013): 1841-1847. https://doi.org/10.3892/or.2013.2639
Copy and paste a formatted citation
x
Spandidos Publications style
Yi B, Zhang Z, Zhang M, Schwartz-Albiez R and Cao Y: CD176 antiserum treatment leads to a therapeutic response in a murine model of leukemia. Oncol Rep 30: 1841-1847, 2013.
APA
Yi, B., Zhang, Z., Zhang, M., Schwartz-Albiez, R., & Cao, Y. (2013). CD176 antiserum treatment leads to a therapeutic response in a murine model of leukemia. Oncology Reports, 30, 1841-1847. https://doi.org/10.3892/or.2013.2639
MLA
Yi, B., Zhang, Z., Zhang, M., Schwartz-Albiez, R., Cao, Y."CD176 antiserum treatment leads to a therapeutic response in a murine model of leukemia". Oncology Reports 30.4 (2013): 1841-1847.
Chicago
Yi, B., Zhang, Z., Zhang, M., Schwartz-Albiez, R., Cao, Y."CD176 antiserum treatment leads to a therapeutic response in a murine model of leukemia". Oncology Reports 30, no. 4 (2013): 1841-1847. https://doi.org/10.3892/or.2013.2639
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