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Article Open Access

Plasma osteopontin concentrations in patients with cutaneous melanoma

  • Authors:
    • A. Filia
    • F. Elliott
    • T. Wind
    • S. Field
    • J. Davies
    • K. Kukalizch
    • J. Randerson-Moor
    • M. Harland
    • D. T. Bishop
    • R. E. Banks
    • J. A. Newton-Bishop
  • View Affiliations / Copyright

    Affiliations: Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, St. James's University Hospital, Leeds LS9 7TF, UK, Section of Oncology and Clinical Research, Leeds Institute of Cancer and Pathology, St. James's University Hospital, Leeds LS9 7TF, UK
    Copyright: © Filia et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 1575-1580
    |
    Published online on: August 8, 2013
       https://doi.org/10.3892/or.2013.2666
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Abstract

An effective circulating tumour marker is needed for melanoma especially with the advent of targeted therapies. Gene expression studies examining primary melanomas have shown that increased expression of osteopontin (SPP1) is associated with poor prognosis. Studies subsequently reported higher blood levels in melanoma patients with metastatic disease than those without. This study was designed to determine whether osteopontin plasma concentrations in disease-free patients after initial treatment predict survival. An enzyme-linked immunosorbent assay (ELISA) was used to measure osteopontin levels in stored plasma samples (N=215) from participants in the Leeds Melanoma Cohort. AJCC stage at sampling was statistically significant associated with osteopontin levels (p=0.03). Participants with untreated stage IV disease at sampling (n=10) had higher median osteopontin levels compared to those with treated stage I-III disease (n=158) (p<0.001) confirming previous findings. There was a trend for increased risk of death with increasing osteopontin levels but this was not statistically significant. If a level of 103.14 ng/ml (95th centile of healthy controls) was taken as the upper end of the normal range then 2.5% of patients with treated stage I-III (4/110), 17.6% of patients with untreated stage III (3/17) and 30% of patients with untreated stage IV disease (3/10) had higher levels. These findings suggest that plasma osteopontin levels warrant investigation as a tumour marker in a larger study in which the significance of change in levels over time should be studied in relation to detectable disease recurrence.
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Copy and paste a formatted citation
Spandidos Publications style
Filia A, Elliott F, Wind T, Field S, Davies J, Kukalizch K, Randerson-Moor J, Harland M, Bishop DT, Banks RE, Banks RE, et al: Plasma osteopontin concentrations in patients with cutaneous melanoma. Oncol Rep 30: 1575-1580, 2013.
APA
Filia, A., Elliott, F., Wind, T., Field, S., Davies, J., Kukalizch, K. ... Newton-Bishop, J.A. (2013). Plasma osteopontin concentrations in patients with cutaneous melanoma. Oncology Reports, 30, 1575-1580. https://doi.org/10.3892/or.2013.2666
MLA
Filia, A., Elliott, F., Wind, T., Field, S., Davies, J., Kukalizch, K., Randerson-Moor, J., Harland, M., Bishop, D. T., Banks, R. E., Newton-Bishop, J. A."Plasma osteopontin concentrations in patients with cutaneous melanoma". Oncology Reports 30.4 (2013): 1575-1580.
Chicago
Filia, A., Elliott, F., Wind, T., Field, S., Davies, J., Kukalizch, K., Randerson-Moor, J., Harland, M., Bishop, D. T., Banks, R. E., Newton-Bishop, J. A."Plasma osteopontin concentrations in patients with cutaneous melanoma". Oncology Reports 30, no. 4 (2013): 1575-1580. https://doi.org/10.3892/or.2013.2666
Copy and paste a formatted citation
x
Spandidos Publications style
Filia A, Elliott F, Wind T, Field S, Davies J, Kukalizch K, Randerson-Moor J, Harland M, Bishop DT, Banks RE, Banks RE, et al: Plasma osteopontin concentrations in patients with cutaneous melanoma. Oncol Rep 30: 1575-1580, 2013.
APA
Filia, A., Elliott, F., Wind, T., Field, S., Davies, J., Kukalizch, K. ... Newton-Bishop, J.A. (2013). Plasma osteopontin concentrations in patients with cutaneous melanoma. Oncology Reports, 30, 1575-1580. https://doi.org/10.3892/or.2013.2666
MLA
Filia, A., Elliott, F., Wind, T., Field, S., Davies, J., Kukalizch, K., Randerson-Moor, J., Harland, M., Bishop, D. T., Banks, R. E., Newton-Bishop, J. A."Plasma osteopontin concentrations in patients with cutaneous melanoma". Oncology Reports 30.4 (2013): 1575-1580.
Chicago
Filia, A., Elliott, F., Wind, T., Field, S., Davies, J., Kukalizch, K., Randerson-Moor, J., Harland, M., Bishop, D. T., Banks, R. E., Newton-Bishop, J. A."Plasma osteopontin concentrations in patients with cutaneous melanoma". Oncology Reports 30, no. 4 (2013): 1575-1580. https://doi.org/10.3892/or.2013.2666
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