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Article

High levels of EphA3 expression are associated with high invasive capacity and poor overall survival in hepatocellular carcinoma

  • Authors:
    • Cheng-Yi Lu
    • Zhao-Xu Yang
    • Liang Zhou
    • Zhi-Zhong Huang
    • Hong‑Tao Zhang
    • Jun Li
    • Kai-Shan Tao
    • Bai-Zhi Xie
  • View Affiliations / Copyright

    Affiliations: Department of Information, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shannxi 710032, P.R. China, Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shannxi 710032, P.R. China, Department of General Surgery, The 155 Central Hospital of PLA, Kaifeng, He'nan 471000, P.R. China, The Fourth Military Medical University, Xi'an, Shannxi 710032, P.R. China
  • Pages: 2179-2186
    |
    Published online on: August 21, 2013
       https://doi.org/10.3892/or.2013.2679
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Abstract

Although EphA3 expression has been associated with progression or prognosis in several types of tumors, the role of EphA3 in hepatocellular carcinoma (HCC) remains unknown. This study sought to investigate the clinicopathological and prognostic relevance of EphA3 expression in HCC as well as the underlying mechanisms responsible. EphA3 protein was mainly localized within the cytoplasm and at the cell membrane. High EphA3 expression was correlated with tumor size, tumor grade, metastasis, venous invasion and AJCC TNM stage (P<0.05), and patients with high levels of EphA3 expression were at a significantly increased risk for shortened survival time (P<0.05). In vitro, the downregulation of EphA3 expression decreased the invasive capacity of HCC cells via the regulation of VEGF. EphA3 may represent a novel candidate marker for patient prognosis as well a molecular target for HCC therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Lu C, Yang Z, Zhou L, Huang Z, Zhang HT, Li J, Tao K and Xie B: High levels of EphA3 expression are associated with high invasive capacity and poor overall survival in hepatocellular carcinoma. Oncol Rep 30: 2179-2186, 2013.
APA
Lu, C., Yang, Z., Zhou, L., Huang, Z., Zhang, H., Li, J. ... Xie, B. (2013). High levels of EphA3 expression are associated with high invasive capacity and poor overall survival in hepatocellular carcinoma. Oncology Reports, 30, 2179-2186. https://doi.org/10.3892/or.2013.2679
MLA
Lu, C., Yang, Z., Zhou, L., Huang, Z., Zhang, H., Li, J., Tao, K., Xie, B."High levels of EphA3 expression are associated with high invasive capacity and poor overall survival in hepatocellular carcinoma". Oncology Reports 30.5 (2013): 2179-2186.
Chicago
Lu, C., Yang, Z., Zhou, L., Huang, Z., Zhang, H., Li, J., Tao, K., Xie, B."High levels of EphA3 expression are associated with high invasive capacity and poor overall survival in hepatocellular carcinoma". Oncology Reports 30, no. 5 (2013): 2179-2186. https://doi.org/10.3892/or.2013.2679
Copy and paste a formatted citation
x
Spandidos Publications style
Lu C, Yang Z, Zhou L, Huang Z, Zhang HT, Li J, Tao K and Xie B: High levels of EphA3 expression are associated with high invasive capacity and poor overall survival in hepatocellular carcinoma. Oncol Rep 30: 2179-2186, 2013.
APA
Lu, C., Yang, Z., Zhou, L., Huang, Z., Zhang, H., Li, J. ... Xie, B. (2013). High levels of EphA3 expression are associated with high invasive capacity and poor overall survival in hepatocellular carcinoma. Oncology Reports, 30, 2179-2186. https://doi.org/10.3892/or.2013.2679
MLA
Lu, C., Yang, Z., Zhou, L., Huang, Z., Zhang, H., Li, J., Tao, K., Xie, B."High levels of EphA3 expression are associated with high invasive capacity and poor overall survival in hepatocellular carcinoma". Oncology Reports 30.5 (2013): 2179-2186.
Chicago
Lu, C., Yang, Z., Zhou, L., Huang, Z., Zhang, H., Li, J., Tao, K., Xie, B."High levels of EphA3 expression are associated with high invasive capacity and poor overall survival in hepatocellular carcinoma". Oncology Reports 30, no. 5 (2013): 2179-2186. https://doi.org/10.3892/or.2013.2679
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