|
1
|
Yang JD and Roberts LR: Hepatocellular
carcinoma: a global view. Nat Rev Gastroenterol Hepatol. 7:448–458.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Sandhu DS, Tharayil VS, Lai JP and Roberts
LR: Treatment options for hepatocellular carcinoma. Expert Rev
Gastroenterol Hepatol. 2:81–92. 2008. View Article : Google Scholar
|
|
3
|
Zheng X, Gai X, Han S, et al: The human
sulfatase 2 inhibitor 2,4-disulfonylphenyl-tert-butylnitrone
(OKN-007) has an antitumor effect in hepatocellular carcinoma
mediated via suppression of TGFB1/SMAD2 and Hedgehog/GLI1
signaling. Genes Chromosomes Cancer. 52:225–236. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Zheng X, Vittar NB, Gai X, et al: The
transcription factor GLI1 mediates TGFβ1 driven EMT in
hepatocellular carcinoma via a SNAI1-dependent mechanism. PLoS One.
7:e495812012.
|
|
5
|
Xu QR, Zheng X, Zan XF, Yao YM, Yang W and
Liu QG: Gli1 expression and its relationship with the expression of
Shh, Vimentin and E-cadherin in human hepatocellular carcinoma. Xi
Bao Yu Fen Zi Mian Yi Xue Za Zhi. 28:536–539. 2012.(In
Chinese).
|
|
6
|
Zheng X, Yao Y, Xu Q, Tu K and Liu Q:
Evaluation of glioma-associated oncogene 1 expression and its
correlation with the expression of sonic hedgehog, E-cadherin and
S100a4 in human hepatocellular carcinoma. Mol Med Rep. 3:965–970.
2010.PubMed/NCBI
|
|
7
|
Nüsslein-Volhard C and Wieschaus E:
Mutations affecting segment number and polarity in
Drosophila. Nature. 287:795–801. 1980.
|
|
8
|
Heretsch P, Tzagkaroulaki L and Giannis A:
Modulators of the hedgehog signaling pathway. Bioorg Med Chem.
18:6613–6624. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Pepinsky RB, Zeng C, Wen D, et al:
Identification of a palmitic acid-modified form of human Sonic
hedgehog. J Biol Chem. 273:14037–14045. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Porter JA, Young KE and Beachy PA:
Cholesterol modification of hedgehog signaling proteins in animal
development. Science. 274:255–259. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Kinzler KW, Bigner SH, Bigner DD, et al:
Identification of an amplified, highly expressed gene in a human
glioma. Science. 236:70–73. 1987. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Corbit KC, Aanstad P, Singla V, Norman AR,
Stainier DY and Reiter JF: Vertebrate Smoothened functions at the
primary cilium. Nature. 437:1018–1021. 2005. View Article : Google Scholar
|
|
13
|
Huangfu D and Anderson KV: Cilia and
Hedgehog responsiveness in the mouse. Proc Natl Acad Sci USA.
102:11325–11330. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Ruiz i Altaba A, Mas C and Stecca B: The
Gli code: an information nexus regulating cell fate, stemness and
cancer. Trends Cell Biol. 17:438–447. 2007.PubMed/NCBI
|
|
15
|
Kenney AM, Cole MD and Rowitch DH: Nmyc
upregulation by sonic hedgehog signaling promotes proliferation in
developing cerebellar granule neuron precursors. Development.
130:15–28. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Kasper M, Schnidar H, Neill GW, et al:
Selective modulation of Hedgehog/GLI target gene expression by
epidermal growth factor signaling in human keratinocytes. Mol Cell
Biol. 26:6283–6298. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Yoon JW, Kita Y, Frank DJ, et al: Gene
expression profiling leads to identification of GLI1-binding
elements in target genes and a role for multiple downstream
pathways in GLI1-induced cell transformation. J Biol Chem.
277:5548–5555. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Teh MT, Blaydon D, Chaplin T, et al:
Genomewide single nucleotide polymorphism microarray mapping in
basal cell carcinomas unveils uniparental disomy as a key somatic
event. Cancer Res. 65:8597–8603. 2005. View Article : Google Scholar
|
|
19
|
Eichberger T, Kaser A, Pixner C, et al:
GLI2-specific transcriptional activation of the bone morphogenetic
protein/activin antagonist follistatin in human epidermal cells. J
Biol Chem. 283:12426–12437. 2008. View Article : Google Scholar
|
|
20
|
Kump E, Ji J, Wernli M, Häusermann P and
Erb P: Gli2 upregulates cFlip and renders basal cell carcinoma
cells resistant to death ligand-mediated apoptosis. Oncogene.
27:3856–3864. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Hallikas O, Palin K, Sinjushina N, et al:
Genome-wide prediction of mammalian enhancers based on analysis of
transcription-factor binding affinity. Cell. 124:47–59. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Li X, Deng W, Lobo-Ruppert SM and Ruppert
JM: Gli1 acts through Snail and E-cadherin to promote nuclear
signaling by β-catenin. Oncogene. 26:4489–4498. 2007.PubMed/NCBI
|
|
23
|
Kasper M, Regl G, Frischauf AM and Aberger
F: GLI transcription factors: mediators of oncogenic Hedgehog
signalling. Eur J Cancer. 42:437–445. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Fernandez-Zapico ME: Primers on molecular
pathways GLI: more than just Hedgehog? Pancreatology. 8:227–229.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Stecca B, Mas C, Clement V, et al:
Melanomas require HEDGEHOG-GLI signaling regulated by interactions
between GLI1 and the RAS-MEK/AKT pathways. Proc Natl Acad Sci USA.
104:5895–5900. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Kudchadkar R, Lewis K and Gonzalez R:
Advances in the treatment of Basal cell carcinoma: Hedgehog
inhibitors. Semin Oncol. 39:139–144. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Wang X, Venugopal C, Manoranjan B, et al:
Sonic hedgehog regulates Bmi1 in human medulloblastoma brain
tumor-initiating cells. Oncogene. 31:187–199. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Singh S, Wang Z, Liang Fei D, et al:
Hedgehog-producing cancer cells respond to and require autocrine
Hedgehog activity. Cancer Res. 71:4454–4463. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Saqui-Salces M and Merchant JL: Hedgehog
signaling and gastrointestinal cancer. Biochim Biophys Acta.
1803:786–795. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Chung MK, Kim HJ, Lee YS, et al: Hedgehog
signaling regulates proliferation of prostate cancer cells via
stathmin1. Clin Exp Med. 10:51–57. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Tian H, Callahan CA, DuPree KJ, et al:
Hedgehog signaling is restricted to the stromal compartment during
pancreatic carcinogenesis. Proc Natl Acad Sci USA. 106:4254–4259.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Dierks C, Grbic J, Zirlik K, et al:
Essential role of stromally induced hedgehog signaling in B-cell
malignancies. Nat Med. 13:944–951. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Becher OJ, Hambardzumyan D, Fomchenko EI,
et al: Gli activity correlates with tumor grade in platelet-derived
growth factor-induced gliomas. Cancer Res. 68:2241–2249. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Romer JT, Kimura H, Magdaleno S, et al:
Suppression of the Shh pathway using a small molecule inhibitor
eliminates medulloblastoma in
Ptc1+/−p53−/− mice. Cancer
Cell. 6:229–240. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Gailani MR, Ståhle-Bäckdahl M, Leffell DJ,
et al: The role of the human homologue of Drosophila patched
in sporadic basal cell carcinomas. Nat Genet. 14:78–81.
1996.PubMed/NCBI
|
|
36
|
Watkins DN, Berman DM, Burkholder SG, Wang
B, Beachy PA and Baylin SB: Hedgehog signalling within airway
epithelial progenitors and in small-cell lung cancer. Nature.
422:313–317. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Lauth M, Bergström A, Shimokawa T, et al:
DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling
by mutant RAS. Nat Struct Mol Biol. 17:718–725. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Katano M: Hedgehog signaling pathway as a
therapeutic target in breast cancer. Cancer Lett. 227:99–104. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Hatsell S and Frost AR: Hedgehog signaling
in mammary gland development and breast cancer. J Mammary Gland
Biol Neoplasia. 12:163–173. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Kasper M, Jaks V, Fiaschi M and Toftgård
R: Hedgehog signalling in breast cancer. Carcinogenesis.
30:903–911. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Wang LH, Choi YL, Hua XY, et al: Increased
expression of sonic hedgehog and altered methylation of its
promoter region in gastric cancer and its related lesions. Mod
Pathol. 19:675–683. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Varnat F, Duquet A, Malerba M, et al:
Human colon cancer epithelial cells harbour active HEDGEHOG-GLI
signalling that is essential for tumour growth, recurrence,
metastasis and stem cell survival and expansion. EMBO Mol Med.
1:338–351. 2009. View Article : Google Scholar
|
|
43
|
Mazumdar T, DeVecchio J, Agyeman A, Shi T
and Houghton JA: The GLI genes as the molecular switch in
disrupting Hedgehog signaling in colon cancer. Oncotarget.
2:638–645. 2011.PubMed/NCBI
|
|
44
|
Wang WS, Chen PM and Su Y: Colorectal
carcinoma: from tumorigenesis to treatment. Cell Mol Life Sci.
63:663–671. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Theunissen JW and de Sauvage FJ: Paracrine
Hedgehog signaling in cancer. Cancer Res. 69:6007–6010. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Lu JT, Zhao WD, He W and Wei W: Hedgehog
signaling pathway mediates invasion and metastasis of
hepatocellular carcinoma via ERK pathway. Acta Pharmacol Sin.
33:691–700. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Wang Y, Han C, Lu L, Magliato S and Wu T:
Hedgehog signaling pathway regulates autophagy in human
hepatocellular carcinoma cells. Hepatology. Mar 16–2013.(Epub ahead
of print).
|
|
48
|
Sicklick JK, Li YX, Jayaraman A, et al:
Dysregulation of the Hedgehog pathway in human
hepatocarcinogenesis. Carcinogenesis. 27:748–757. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Tada M, Kanai F, Tanaka Y, et al:
Down-regulation of hedgehog-interacting protein through genetic and
epigenetic alterations in human hepatocellular carcinoma. Clin
Cancer Res. 14:3768–3776. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Chan IS, Guy CD, Chen Y, et al: Paracrine
Hedgehog signaling drives metabolic changes in hepatocellular
carcinoma. Cancer Res. 72:6344–6350. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Arzumanyan A, Sambandam V, Clayton MM, et
al: Hedgehog signaling blockade delays hepatocarcinogenesis induced
by hepatitis B virus X protein. Cancer Res. 72:5912–5920. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
52
|
de Pereira TA, Witek RP, Syn WK, et al:
Viral factors induce Hedgehog pathway activation in humans with
viral hepatitis, cirrhosis, and hepatocellular carcinoma. Lab
Invest. 90:1690–1703. 2010.PubMed/NCBI
|
|
53
|
Philips GM, Chan IS, Swiderska M, et al:
Hedgehog signaling antagonist promotes regression of both liver
fibrosis and hepatocellular carcinoma in a murine model of primary
liver cancer. PLoS One. 6:e239432011. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Chen X, Lingala S, Khoobyari S, Nolta J,
Zern MA and Wu J: Epithelial mesenchymal transition and hedgehog
signaling activation are associated with chemoresistance and
invasion of hepatoma subpopulations. J Hepatol. 55:838–845. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Cooper MK, Porter JA, Young KE and Beachy
PA: Teratogen-mediated inhibition of target tissue response to Shh
signaling. Science. 280:1603–1607. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Rubin LL and de Sauvage FJ: Targeting the
Hedgehog pathway in cancer. Nat Rev Drug Discov. 5:1026–1033. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Robarge KD, Brunton SA, Castanedo GM, et
al: GDC-0449-a potent inhibitor of the hedgehog pathway. Bioorg Med
Chem Lett. 19:5576–5581. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Yauch RL, Gould SE, Scales SJ, et al: A
paracrine requirement for hedgehog signalling in cancer. Nature.
455:406–410. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Tian F, Mysliwietz J, Ellwart J, Gamarra
F, Huber RM and Bergner A: Effects of the Hedgehog pathway
inhibitor GDC-0449 on lung cancer cell lines are mediated by side
populations. Clin Exp Med. 12:25–30. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Ailles L and Siu LL: Targeting the
Hedgehog pathway in cancer: can the spines be smoothened? Clin
Cancer Res. 17:2071–2073. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Singh BN, Fu J, Srivastava RK and Shankar
S: Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits
pancreatic cancer stem cell characteristics: molecular mechanisms.
PLoS One. 6:e273062011. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Von Hoff DD, LoRusso PM, Rudin CM, et al:
Inhibition of the hedgehog pathway in advanced basal-cell
carcinoma. N Engl J Med. 361:1164–1172. 2009.PubMed/NCBI
|
|
63
|
De Smaele E, Ferretti E and Gulino A:
Vismodegib, a small-molecule inhibitor of the hedgehog pathway for
the treatment of advanced cancers. Curr Opin Investig Drugs.
11:707–718. 2010.PubMed/NCBI
|
|
64
|
Rudin CM: Vismodegib. Clin Cancer Res.
18:3218–3222. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Axelson M, Liu K, Jiang X, et al: U.S.
Food and Drug Administration approval: vismodegib for recurrent,
locally advanced, or metastatic basal cell carcinoma. Clin Cancer
Res. 19:2289–2293. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Skvara H, Kalthoff F, Meingassner JG, et
al: Topical treatment of Basal cell carcinomas in nevoid Basal cell
carcinoma syndrome with a smoothened inhibitor. J Invest Dermatol.
131:1735–1744. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Li Y, Maitah MY, Ahmad A, Kong D, Bao B
and Sarkar FH: Targeting the Hedgehog signaling pathway for cancer
therapy. Expert Opin Ther Targets. 16:49–66. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Lauth M, Bergström A, Shimokawa T and
Toftgård R: Inhibition of GLI-mediated transcription and tumor cell
growth by small-molecule antagonists. Proc Natl Acad Sci USA.
104:8455–8460. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Fu J, Rodova M, Roy SK, et al: GANT-61
inhibits pancreatic cancer stem cell growth in vitro and in
NOD/SCID/IL2R gamma null mice xenograft. Cancer Lett. 330:22–32.
2013. View Article : Google Scholar : PubMed/NCBI
|
