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Article

Cytotoxic effects of mistletoe (Viscum album L.) in head and neck squamous cell carcinoma cell lines

  • Authors:
    • M. Fátima G. Klingbeil
    • Flávia C.A. Xavier
    • Luiz R. Sardinha
    • Patricia Severino
    • Monica B. Mathor
    • Rodrigo V. Rodrigues
    • Décio S. Pinto
  • View Affiliations / Copyright

    Affiliations: Department of Oral Pathology, School of Dentistry, University of São Paulo, 05508-000 São Paulo, Brazil, Federal University of Bahia, School of Dentistry Salvador, Canela, 40110-150 Bahia, Brazil, Centro de Pesquisa Experimental do Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE), 0565-000 São Paulo, Brazil , Centro de Pesquisa Experimental do Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE), 0565-000 São Paulo, Brazil, Radiation Technology Center (CTR), Nuclear and Energetic Research Institute (IPEN-CNEN/SP), 05508-000 São Paulo, Brazil, Department of Genetics and Evolutionary Biology, Institute of Biosciences, University of São Paulo, 05508-090 São Paulo, Brazil
  • Pages: 2316-2322
    |
    Published online on: September 10, 2013
       https://doi.org/10.3892/or.2013.2732
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Abstract

Head and neck squamous cell carcinoma is a complex disease with several etiologic factors and different molecular changes that may trigger certain events; it is also globally one of the most common malignancies in this topography. Extracts from Viscum album L. (VA) (mistletoe) have been used as adjuvant therapies with promising results in several types of cancer, mainly in European countries. In vitro studies have demonstrated that various types of VA may have cytotoxicity in carcinoma cells, activating the apoptotic cascade or leading cells to necrosis. This study aimed to verify the effects of three types of VA extracts (Iscador Qu Spezial, Iscador P and Iscador M) in squamous cell carcinoma of the tongue cell lines SCC9 and SCC25, not previously studied. A concentration of 0.3 mg/ml (IC50) of the drugs induced apoptosis, affecting gene expression and protein levels of AKT, PTEN and CYCLIN D1. It was concluded that VA extracts have a cytotoxic effect on SCC9 and SCC25 cell lines, but while SCC9 cell line was more resistant to the action of the drugs, Iscador Qu Spezial and Iscador M have higher cytotoxic potential in both cell lines compared to Iscador P.
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Copy and paste a formatted citation
Spandidos Publications style
Klingbeil MF, Xavier FC, Sardinha LR, Severino P, Mathor MB, Rodrigues RV and Pinto DS: Cytotoxic effects of mistletoe (Viscum album L.) in head and neck squamous cell carcinoma cell lines. Oncol Rep 30: 2316-2322, 2013.
APA
Klingbeil, M.F., Xavier, F.C., Sardinha, L.R., Severino, P., Mathor, M.B., Rodrigues, R.V., & Pinto , D.S. (2013). Cytotoxic effects of mistletoe (Viscum album L.) in head and neck squamous cell carcinoma cell lines. Oncology Reports, 30, 2316-2322. https://doi.org/10.3892/or.2013.2732
MLA
Klingbeil, M. F., Xavier, F. C., Sardinha, L. R., Severino, P., Mathor, M. B., Rodrigues, R. V., Pinto , D. S."Cytotoxic effects of mistletoe (Viscum album L.) in head and neck squamous cell carcinoma cell lines". Oncology Reports 30.5 (2013): 2316-2322.
Chicago
Klingbeil, M. F., Xavier, F. C., Sardinha, L. R., Severino, P., Mathor, M. B., Rodrigues, R. V., Pinto , D. S."Cytotoxic effects of mistletoe (Viscum album L.) in head and neck squamous cell carcinoma cell lines". Oncology Reports 30, no. 5 (2013): 2316-2322. https://doi.org/10.3892/or.2013.2732
Copy and paste a formatted citation
x
Spandidos Publications style
Klingbeil MF, Xavier FC, Sardinha LR, Severino P, Mathor MB, Rodrigues RV and Pinto DS: Cytotoxic effects of mistletoe (Viscum album L.) in head and neck squamous cell carcinoma cell lines. Oncol Rep 30: 2316-2322, 2013.
APA
Klingbeil, M.F., Xavier, F.C., Sardinha, L.R., Severino, P., Mathor, M.B., Rodrigues, R.V., & Pinto , D.S. (2013). Cytotoxic effects of mistletoe (Viscum album L.) in head and neck squamous cell carcinoma cell lines. Oncology Reports, 30, 2316-2322. https://doi.org/10.3892/or.2013.2732
MLA
Klingbeil, M. F., Xavier, F. C., Sardinha, L. R., Severino, P., Mathor, M. B., Rodrigues, R. V., Pinto , D. S."Cytotoxic effects of mistletoe (Viscum album L.) in head and neck squamous cell carcinoma cell lines". Oncology Reports 30.5 (2013): 2316-2322.
Chicago
Klingbeil, M. F., Xavier, F. C., Sardinha, L. R., Severino, P., Mathor, M. B., Rodrigues, R. V., Pinto , D. S."Cytotoxic effects of mistletoe (Viscum album L.) in head and neck squamous cell carcinoma cell lines". Oncology Reports 30, no. 5 (2013): 2316-2322. https://doi.org/10.3892/or.2013.2732
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