Caudatin inhibits human hepatoma cell growth and metastasis through modulation of the Wnt/β-catenin pathway

  • Authors:
    • Yi Luo
    • Zhiguang Sun
    • Youbin Li
    • Lina Liu
    • Xueting Cai
    • Zhenlin Li
  • View Affiliations

  • Published online on: September 20, 2013     https://doi.org/10.3892/or.2013.2749
  • Pages: 2923-2928
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Abstract

In the present study, we investigated the antitumor activity of caudatin in the human hepatoma cell line SMMC‑7721 by analysis of cell viability, cell cycle distribution, apoptosis and metastasis. The results showed that caudatin impaired the cell viability and inhibited the growth of SMMC-7721 cells in a time- and dose-dependent manner and resulted in cell cycle arrest in the G2 phase. In addition, SMMC-7721 cells, treated with caudatin exhibited typical characteristics of apoptosis. Furthermore, caudatin treatment resulted in a decrease in β-catenin and GSK3β in SMMC-7721 cells, with a concomitant reduction in metastatic capability and expression of Wnt signaling pathway targeted genes including cox-2, mmp-2 and mmp-9. Our findings revealed that caudatin inhibits human hepatoma cell growth and metastasis by targeting the GSK3β/β-catenin pathway and suppressing VEGF production.
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December 2013
Volume 30 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Luo Y, Sun Z, Li Y, Liu L, Cai X and Li Z: Caudatin inhibits human hepatoma cell growth and metastasis through modulation of the Wnt/β-catenin pathway. Oncol Rep 30: 2923-2928, 2013.
APA
Luo, Y., Sun, Z., Li, Y., Liu, L., Cai, X., & Li, Z. (2013). Caudatin inhibits human hepatoma cell growth and metastasis through modulation of the Wnt/β-catenin pathway. Oncology Reports, 30, 2923-2928. https://doi.org/10.3892/or.2013.2749
MLA
Luo, Y., Sun, Z., Li, Y., Liu, L., Cai, X., Li, Z."Caudatin inhibits human hepatoma cell growth and metastasis through modulation of the Wnt/β-catenin pathway". Oncology Reports 30.6 (2013): 2923-2928.
Chicago
Luo, Y., Sun, Z., Li, Y., Liu, L., Cai, X., Li, Z."Caudatin inhibits human hepatoma cell growth and metastasis through modulation of the Wnt/β-catenin pathway". Oncology Reports 30, no. 6 (2013): 2923-2928. https://doi.org/10.3892/or.2013.2749