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December 2013 Volume 30 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Caudatin inhibits human hepatoma cell growth and metastasis through modulation of the Wnt/β-catenin pathway

  • Authors:
    • Yi Luo
    • Zhiguang Sun
    • Youbin Li
    • Lina Liu
    • Xueting Cai
    • Zhenlin Li
  • View Affiliations / Copyright

    Affiliations: Institute of First Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210046, P.R. China, Laboratory of Traditional Chinese Medicine Chemistry, Jiangsu Province Institute of Traditional Chinese Medicine, Nanjing, Jiangsu 210028, P.R. China, Laboratory of Cellular and Molecular Biology, Jiangsu Province Institute of Traditional Chinese Medicine, Nanjing, Jiangsu 210028, P.R. China
  • Pages: 2923-2928
    |
    Published online on: September 20, 2013
       https://doi.org/10.3892/or.2013.2749
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Abstract

In the present study, we investigated the antitumor activity of caudatin in the human hepatoma cell line SMMC‑7721 by analysis of cell viability, cell cycle distribution, apoptosis and metastasis. The results showed that caudatin impaired the cell viability and inhibited the growth of SMMC-7721 cells in a time- and dose-dependent manner and resulted in cell cycle arrest in the G2 phase. In addition, SMMC-7721 cells, treated with caudatin exhibited typical characteristics of apoptosis. Furthermore, caudatin treatment resulted in a decrease in β-catenin and GSK3β in SMMC-7721 cells, with a concomitant reduction in metastatic capability and expression of Wnt signaling pathway targeted genes including cox-2, mmp-2 and mmp-9. Our findings revealed that caudatin inhibits human hepatoma cell growth and metastasis by targeting the GSK3β/β-catenin pathway and suppressing VEGF production.
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Copy and paste a formatted citation
Spandidos Publications style
Luo Y, Sun Z, Li Y, Liu L, Cai X and Li Z: Caudatin inhibits human hepatoma cell growth and metastasis through modulation of the Wnt/β-catenin pathway. Oncol Rep 30: 2923-2928, 2013.
APA
Luo, Y., Sun, Z., Li, Y., Liu, L., Cai, X., & Li, Z. (2013). Caudatin inhibits human hepatoma cell growth and metastasis through modulation of the Wnt/β-catenin pathway. Oncology Reports, 30, 2923-2928. https://doi.org/10.3892/or.2013.2749
MLA
Luo, Y., Sun, Z., Li, Y., Liu, L., Cai, X., Li, Z."Caudatin inhibits human hepatoma cell growth and metastasis through modulation of the Wnt/β-catenin pathway". Oncology Reports 30.6 (2013): 2923-2928.
Chicago
Luo, Y., Sun, Z., Li, Y., Liu, L., Cai, X., Li, Z."Caudatin inhibits human hepatoma cell growth and metastasis through modulation of the Wnt/β-catenin pathway". Oncology Reports 30, no. 6 (2013): 2923-2928. https://doi.org/10.3892/or.2013.2749
Copy and paste a formatted citation
x
Spandidos Publications style
Luo Y, Sun Z, Li Y, Liu L, Cai X and Li Z: Caudatin inhibits human hepatoma cell growth and metastasis through modulation of the Wnt/β-catenin pathway. Oncol Rep 30: 2923-2928, 2013.
APA
Luo, Y., Sun, Z., Li, Y., Liu, L., Cai, X., & Li, Z. (2013). Caudatin inhibits human hepatoma cell growth and metastasis through modulation of the Wnt/β-catenin pathway. Oncology Reports, 30, 2923-2928. https://doi.org/10.3892/or.2013.2749
MLA
Luo, Y., Sun, Z., Li, Y., Liu, L., Cai, X., Li, Z."Caudatin inhibits human hepatoma cell growth and metastasis through modulation of the Wnt/β-catenin pathway". Oncology Reports 30.6 (2013): 2923-2928.
Chicago
Luo, Y., Sun, Z., Li, Y., Liu, L., Cai, X., Li, Z."Caudatin inhibits human hepatoma cell growth and metastasis through modulation of the Wnt/β-catenin pathway". Oncology Reports 30, no. 6 (2013): 2923-2928. https://doi.org/10.3892/or.2013.2749
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