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Article Open Access

Gender-dependent effects of gonadectomy on lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female and male A/J mice

  • Authors:
    • Fumiko Ninomiya
    • Masanao Yokohira
    • Sosuke Kishi
    • Yuko Nakano
    • Keiko Yamakawa
    • Tatsushi Inoue
    • Toshiya Kuno
    • Katsumi Imaida
  • View Affiliations / Copyright

    Affiliations: Onco-Pathology, Department of Pathology and Host-Defense, Faculty of Medicine, Kagawa University, Miki-cho, Kita-gun, Kagawa 761-0793, Japan
    Copyright: © Ninomiya et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 2632-2638
    |
    Published online on: October 1, 2013
       https://doi.org/10.3892/or.2013.2759
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Abstract

The present study was conducted to investigate the effects of gonadectomy on lung carcinogenesis in female and male mice, and to determine an association between sex hormone and lung carcinogenesis. Female and male A/J mice were divided into gonadectomized and unoperated control groups and all animals were treated intraperitoneally with 1 or 2 injections of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) at the dose of 2 mg/mouse. The mice were sacrificed 18 or 56 weeks after surgery. Serum levels of estradiol in females and testosterone in males were confirmed to be decreased by gonadectomy. Lung white nodules were detected in all mice of all groups. In the control groups of 18- and 56-week studies, the multiplicities of lung nodules in females were significantly greater than in males. In males in the 56-week study, the multiplicity of macroscopical lung nodules, bronchiolo-alveolar hyperplasias, adenomas and tumors (adenomas and adenocarcinomas) showed significant increase with castration. In females in the 18-week study, the multiplicity of adenomas decreased significantly by ovariectomy. Based on the results of the present study, female A/J mice were confirmed to be more susceptible to NNK-induced lung carcinogenesis than males. Furthermore, it was suggested that the process is inhibited by testosterone and accelerated by estradiol. These findings indicate the possibility that sex hormones play important roles in determining sex differences in lung carcinogenesis in the A/J mice initiated by NNK.
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1 

Balbo S, Upadhyaya P, Villalta PW, Qian X and Kassie F: DNA adducts in aldehyde dehydrogenase-positive lung stem cells of A/J mice treated with the tobacco specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Chem Res Toxicol. Mar 12–2013.(Epub ahead of print).

2 

Akopyan G and Bonavida B: Understanding tobacco smoke carcinogen NNK and lung tumorigenesis (Review). Int J Oncol. 29:745–752. 2006.PubMed/NCBI

3 

Chen RJ, Chang LW, Lin P and Wang YJ: Epigenetic effects and molecular mechanisms of tumorigenesis induced by cigarette smoke: an overview. J Oncol. 2011:6549312011.PubMed/NCBI

4 

Belinsky SA, Devereux TR, Foley JF, Maronpot RR and Anderson MW: Role of the alveolar type II cell in the development and progression of pulmonary tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the A/J mouse. Cancer Res. 52:3164–3173. 1992.PubMed/NCBI

5 

Imaida K, Yokohira M and Kuno T: Detection of carcinogenic and modifying potentials by test compounds using a mouse lung carcinogenesis bioassay (Review). J Toxicol Pathol. 20:117–123. 2007. View Article : Google Scholar

6 

Takeuchi H, Saoo K, Matsuda Y, et al: 8-Methoxypsoralen, a potent human CYP2A6 inhibitor, inhibits lung adenocarcinoma development induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice. Mol Med Rep. 2:585–588. 2009.

7 

Takeuchi H, Saoo K, Matsuda Y, et al: Dose dependent inhibitory effects of dietary 8-methoxypsoralen on NNK-induced lung tumorigenesis in female A/J mice. Cancer Lett. 234:232–238. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Takeuchi H, Saoo K, Yokohira M, et al: Pretreatment with 8-methoxypsoralen, a potent human CYP2A6 inhibitor, strongly inhibits lung tumorigenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice. Cancer Res. 63:7581–7583. 2003.

9 

Yokohira M, Takeuchi H, Saoo K, et al: Establishment of a bioassay model for lung cancer chemoprevention initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female A/J mice. Exp Toxicol Pathol. 60:469–473. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Kuno T, Yokohira M, Matsuda Y, et al: Lack of modifying potential of 8-methoxypsoralen in the promotion or progression stages of lung carcinogenesis in A/J female mice. Oncol Rep. 20:767–772. 2008.PubMed/NCBI

11 

Matsuda Y, Saoo K, Hosokawa K, et al: Post-initiation chemopreventive effects of dietary bovine lactoferrin on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in female A/J mice. Cancer Lett. 246:41–46. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Yamakawa K, Kuno T, Hashimoto N, et al: Molecular analysis of carcinogen-induced rodent lung tumors: Involvement of microRNA expression and Kras or Egfr mutations. Mol Med Rep. 3:141–147. 2010.PubMed/NCBI

13 

Yokohira M, Hashimoto N, Yamakawa K, Saoo K, Kuno T and Imaida K: Lack of promoting effects from physical pulmonary collapse in a female A/J mouse lung tumor initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) with remarkable mesothelial cell reactions in the thoracic cavity by the polymer. Exp Toxicol Pathol. 63:181–185. 2011. View Article : Google Scholar

14 

Yokohira M, Hashimoto N, Yamakawa K, et al: Lack of modifying effects of intratracheal instillation of quartz or dextran sulfate sodium (DSS) in drinking water on lung tumor development initiated with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female A/J mice. J Toxicol Pathol. 22:179–185. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Miyazaki M, Yamazaki H, Takeuchi H, et al: Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas. Carcinogenesis. 26:1947–1955. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Igarashi M, Watanabe M, Yoshida M, et al: Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone by Ogg1 gene deficiency in female, but not male, mice. J Toxicol Sci. 34:163–174. 2009.

17 

Morita T: A statistical study of lung cancer in the annual of pathological autopsy cases in Japan, from 1958 to 1997, with reference to time trends of lung cancer in the world. Jpn J Cancer Res. 93:15–23. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Sobue T, Ajiki W, Tsukuma H, Oshima A, Hanai A and Fujimoto I: Trends of lung cancer incidence by histologic type: a population-based study in Osaka, Japan. Jpn J Cancer Res. 90:6–15. 1999. View Article : Google Scholar : PubMed/NCBI

19 

Zang EA and Wynder EL: Differences in lung cancer risk between men and women: examination of the evidence. J Natl Cancer Inst. 88:183–192. 1996. View Article : Google Scholar : PubMed/NCBI

20 

Belani CP, Marts S, Schiller J and Socinski MA: Women and lung cancer: epidemiology, tumor biology, and emerging trends in clinical research. Lung Cancer. 55:15–23. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Nishio M, Ohyanagi F, Horiike A, et al: Gefitinib treatment affects androgen levels in non-small-cell lung cancer patients. Br J Cancer. 92:1877–1880. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Mohr U: International Classification of Rodent Tumors: The Mouse. 1st edition. Springer-Verlag; Berlin: 2001, View Article : Google Scholar

23 

de Kretser DM: The Testis. Reproduction in Mammals: Hormonal Control of Reproduction. Austin CR and Short RV: 3. 2nd edition. Cambridge University Press; Cambridge: pp. 76–90. 1984

24 

Baird DT: The Ovary. Reproduction in Mammals: Hormonal Control of Reproduction. Austin CR and Short RV: 3. 2nd edition. Cambridge University Press; Cambridge: pp. 91–114. 1984, View Article : Google Scholar

25 

Pelletier G, Luu-The V, Li S and Labrie F: Localization of type 5 17β-hydroxysteroid dehydrogenase mRNA in mouse tissues as studied by in situ hybridization. Cell Tissue Res. 320:393–398. 2005.

26 

Matsuura S and Suzuki K: Morphological changes in the submandibular glands and in the X zone of the adrenal gland following ovariectomy in mice. Cell Tissue Res. 246:549–556. 1986. View Article : Google Scholar : PubMed/NCBI

27 

Kamei Y, Suzuki M, Miyazaki H, et al: Ovariectomy in mice decreases lipid metabolism-related gene expression in adipose tissue and skeletal muscle with increased body fat. J Nutr Sci Vitaminol. 51:110–117. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Wu J, Wang X, Chiba H, et al: Combined intervention of soy isoflavone and moderate exercise prevents body fat elevation and bone loss in ovariectomized mice. Metabolism. 53:942–948. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Yamaguchi M, Katoh S, Morimoto C, et al: The hormonal responses of lipoprotein lipase activity and lipolysis in adipose tissue differ depending on the stage of the estrous cycle in female rats. Int J Obes Relat Metab Disord. 26:610–617. 2002. View Article : Google Scholar : PubMed/NCBI

30 

Duffel MW, Graham JM and Ziegler DM: Changes in dimethylaniline N-oxidase activity of mouse liver and kidney induced by steroid sex hormones. Mol Pharmacol. 19:134–139. 1981.PubMed/NCBI

31 

Kamataki T, Fujita KI, Nakayama K, Yamazaki Y, Miyamoto M and Ariyoshi N: Role of human cytochrome P450 (CYP) in the metabolic activation of nitrosamine derivatives: application of genetically engineered Salmonella expressing human CYP. Drug Metab Rev. 34:667–676. 2002. View Article : Google Scholar : PubMed/NCBI

32 

Wiener D, Doerge DR, Fang JL, Upadhyaya P and Lazarus P: Characterization of N-glucuronidation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human liver: importance of UDP-glucuronosyltransferase 1A4. Drug Metab Dispos. 32:72–79. 2004.

33 

Benowitz NL, Lessov-Schlaggar CN, Swan GE and Jacob P III: Female sex and oral contraceptive use accelerate nicotine metabolism. Clinl Pharmacol Ther. 79:480–488. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Miners JO, Grgurinovich N, Whitehead AG, Robson RA and Birkett DJ: Influence of gender and oral contraceptive steroids on the metabolism of salicytic acid and acetylsalicylic acid. Br J Clin Pharmacol. 22:135–142. 1986. View Article : Google Scholar : PubMed/NCBI

35 

Mitchell MC, Hanew T, Meredith CG and Schenker S: Effects of oral contraceptive steroids on acetaminophen metabolism and elimination. Clin Pharmacol Ther. 34:48–53. 1983. View Article : Google Scholar : PubMed/NCBI

36 

Stoehr GP, Kroboth PD, Juhl RP, Wender DB, Phillips JP and Smith RB: Effect of oral contraceptives on triazolam, temazepam, alprazolam, and lorazepam kinetics. Clin Pharmacol Ther. 36:683–690. 1984. View Article : Google Scholar : PubMed/NCBI

37 

Balogh A, Klinger G, Henschel L, Börner A, Vollanth R and Kuhnz W: Influence of ethinylestradiol-containing combination oral contraceptives with gestodene or levonorgestrel on caffeine elimination. Eur J Clin Pharmacol. 48:161–166. 1995. View Article : Google Scholar : PubMed/NCBI

38 

Laine K, Tybring G and Bertilsson L: No sex-related differences but significant inhibition by oral contraceptives of CYP2C19 activity as measured by the probe drugs mephenytoin and omeprazole in healthy Swedish white subjects. Clin Pharmacol Ther. 68:151–159. 2000. View Article : Google Scholar

39 

Slayter KL, Ludwig EA, Lew KH, Middleton E Jr, Ferry JJ and Jusko WJ: Oral contraceptive effects on methylprednisolone pharmacokinetics and pharmacodynamics. Clin Pharmacol Ther. 59:312–321. 1996. View Article : Google Scholar : PubMed/NCBI

40 

Mikkonen L, Pihlajamaa P, Sahu B, Zhang FP and Jänne OA: Androgen receptor and androgen-dependent gene expression in lung. Mol Cell Endocrinol. 317:14–24. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ninomiya F, Yokohira M, Kishi S, Nakano Y, Yamakawa K, Inoue T, Kuno T and Imaida K: Gender-dependent effects of gonadectomy on lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female and male A/J mice. Oncol Rep 30: 2632-2638, 2013.
APA
Ninomiya, F., Yokohira, M., Kishi, S., Nakano, Y., Yamakawa, K., Inoue, T. ... Imaida, K. (2013). Gender-dependent effects of gonadectomy on lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female and male A/J mice. Oncology Reports, 30, 2632-2638. https://doi.org/10.3892/or.2013.2759
MLA
Ninomiya, F., Yokohira, M., Kishi, S., Nakano, Y., Yamakawa, K., Inoue, T., Kuno, T., Imaida, K."Gender-dependent effects of gonadectomy on lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female and male A/J mice". Oncology Reports 30.6 (2013): 2632-2638.
Chicago
Ninomiya, F., Yokohira, M., Kishi, S., Nakano, Y., Yamakawa, K., Inoue, T., Kuno, T., Imaida, K."Gender-dependent effects of gonadectomy on lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female and male A/J mice". Oncology Reports 30, no. 6 (2013): 2632-2638. https://doi.org/10.3892/or.2013.2759
Copy and paste a formatted citation
x
Spandidos Publications style
Ninomiya F, Yokohira M, Kishi S, Nakano Y, Yamakawa K, Inoue T, Kuno T and Imaida K: Gender-dependent effects of gonadectomy on lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female and male A/J mice. Oncol Rep 30: 2632-2638, 2013.
APA
Ninomiya, F., Yokohira, M., Kishi, S., Nakano, Y., Yamakawa, K., Inoue, T. ... Imaida, K. (2013). Gender-dependent effects of gonadectomy on lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female and male A/J mice. Oncology Reports, 30, 2632-2638. https://doi.org/10.3892/or.2013.2759
MLA
Ninomiya, F., Yokohira, M., Kishi, S., Nakano, Y., Yamakawa, K., Inoue, T., Kuno, T., Imaida, K."Gender-dependent effects of gonadectomy on lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female and male A/J mice". Oncology Reports 30.6 (2013): 2632-2638.
Chicago
Ninomiya, F., Yokohira, M., Kishi, S., Nakano, Y., Yamakawa, K., Inoue, T., Kuno, T., Imaida, K."Gender-dependent effects of gonadectomy on lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female and male A/J mice". Oncology Reports 30, no. 6 (2013): 2632-2638. https://doi.org/10.3892/or.2013.2759
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