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Article

Antitumor effect of 1, 8-cineole against colon cancer

  • Authors:
    • Soichiro Murata
    • Risa Shiragami
    • Chihiro Kosugi
    • Tohru Tezuka
    • Masato Yamazaki
    • Atsushi Hirano
    • Yukino Yoshimura
    • Masato Suzuki
    • Kiyohiko Shuto
    • Nobuhiro Ohkohchi
    • Keiji Koda
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Teikyo University Chiba Medical Center, Ichihara, Japan, Department of Surgery, Division of Gastroenterological and Hepatobiliary Surgery, and Organ Transplantation, University of Tsukuba, Tsukuba, Ibaraki, Japan
  • Pages: 2647-2652
    |
    Published online on: October 1, 2013
       https://doi.org/10.3892/or.2013.2763
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Abstract

Several essential oils possess pharmacological effects. Among the various constituents of essential oils, 1, 8-cineole has been shown to possess pharmacological effects such as anti-bacterial and anti-inflammatory effects. The effect of 1, 8-cineole on human colorectal cancer cells, however, has not reported previously. In this study, we have investigated the anti-proliferative effect of 1, 8-cineole on human colon cancer cell lines HCT116 and RKO by WST-8 and BrdU assays. The cytotoxicity of 1, 8-cineole was investigated by LDH activity and TUNEL staining. The mechanism of apoptosis by 1, 8-cineole was determined by western blot analyses. In in vivo study, RKO cells were injected into the SCID mice and the effect of 1, 8-cineole was investigated. Specific induction of apoptosis, not necrosis, was observed in human colon cancer cell lines HCT116 and RKO by 1, 8-cineole. The treatment with 1, 8-cineole was associated with inactivation of survivin and Akt and activation of p38. These molecules induced cleaved PARP and caspase-3, finally causing apoptosis. In xenotransplanted SCID mice, the 1, 8-cineole group showed significantly inhibited tumor progression compared to the control group. These results indicated 1, 8-cineole suppressed human colorectal cancer proliferation by inducing apoptosis. Based on these studies 1, 8-cineole would be an effective strategy to treat colorectal cancer.
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1 

Pezzuto JM: Plant-derived anticancer agents. Biochem Pharmacol. 53:121–133. 1997. View Article : Google Scholar

2 

Kinghorn AD, Farnsworth NR, Doel Soejarto D, et al: Novel strategies for the discovery of plant-derived anticancer agents. Pure Appl Chem. 71:1611–1618. 1999. View Article : Google Scholar

3 

Lee KH: Anticancer drug design based on plant-derived natural products. J Biomed Sci. 6:236–250. 1999.PubMed/NCBI

4 

Moalic S, Liagre B, Corbiére C, et al: A plant steroid, diosgenin, induces apoptosis, cell cycle arrest and COX activity in osteosarcoma cells. FEBS Lett. 506:225–230. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Fan S, Cherney B, Reinhold W, et al: Disruption of p53 function in immortalized human cells does not affect survival or apoptosis after taxol or vincristine treatment. Clin Can Res. 4:1047–1054. 1998.PubMed/NCBI

6 

Giamakis A, Kretsi O, Chinou IB, et al: Eucalyptus camaldulensis: volatiles from immature flowers and high production of 1,8-cineole and b-pinene by in vitro cultures. Phytochemistry. 58:351–355. 2001. View Article : Google Scholar

7 

Tsiri DO, Kretsi O, Chinou IB, et al: Composition of fruit volatiles and annual changes in the volatiles of leaves of Eucalyptus camandulensis Dehn. Growing in Greece. Flav Fragr J. 18:244–247. 2003. View Article : Google Scholar

8 

Levinson KK, Takayama K, Okabe K, et al: Formulation optimization of indomethacine gels containing a combination of three kinds of cyclic monoterpenes as percutaneous penetration enhancers. J Pharm Sci. 83:1367–1372. 1994. View Article : Google Scholar : PubMed/NCBI

9 

Juergens UR, Stober M, Schmidt-Schilling L, et al: Anti-inflammatory effects of encalyptol (1,8-cineole) in bronchial asthma:inhibition of arachidonic acid metabolism in human blood monocytes ex vivo. Eur J Med Res. 17:407–412. 1998.PubMed/NCBI

10 

Juergens UR, Stober M and Vetter H: Inhibition of cytokine production and arachidonic acid metabolism by eucalyptol (1,8-cineole) in human blood monocytes in vitro. Eur J Med Res. 17:508–510. 1998.PubMed/NCBI

11 

Lahlou S, Figueierdo AF, Magalhaes PJ, et al: Cardiovascular effects of 1,8-cineole, a terpenoid oxide present in many plant essential oils, in normotensive rats. Can J Physiol Pharmacol. 80:1125–1131. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Moteki H, Hibasami H, Yamada Y, et al: Specific induction of apoptosis by 1,8-cineole in two human leukemia cell lines, but not a in human stomach cancer cell line. Oncol Rep. 9:757–760. 2002.PubMed/NCBI

13 

Korzeniewski C and Callewaert DM: An enzyme-release assay for natural cytotoxicity. J Immunol Methods. 64:313–320. 1983. View Article : Google Scholar : PubMed/NCBI

14 

De Sousa AC, Alviano DS, Blank AF, et al: Melissa officinalis L. Essential oil: antitumoral and antioxidant activities. J Pharm Pharmacol. 56:677–681. 2004.

15 

Silva J, Abebe W, Sousa SM, et al: Analgestic and anti-inflammatory effects of essential oils of Eucalyptus. J Ethnopharmacol. 89:277–283. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Williams LR, Stockley JK, Yan W, et al: Essential oils with high antimicrobial activity for therapeutic use. Int J Aromatherapy. 8:30–40. 1998. View Article : Google Scholar

17 

Low D, Rawal BD and Griffin WJ: Antibacterial action of the essential oils of some Australian Myrtaceae with special references to the activity of chromatographic fractions of oil of Eucalyptus citriodora. Planta Med. 26:184–185. 1974. View Article : Google Scholar : PubMed/NCBI

18 

Ramezani H, Singh HP, Batish DR, et al: Antifungal activity of the volatile oil of Eucalyptus citriodora. Fitoterapia. 73:261–262. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Ashour HM: Antibacterial, antifungal and anticancer activities of volatile oils and extracts from stems, leaves and flowers of Eucalyptus sideroxylon and Eucalyptus torquata. Cancer Biol Ther. 7:399–403. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Altieri DC: Validating survivin as a cancer therapeutic target. Nat Rev Cancer. 3:46–54. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Carrasco RA, Stamm NB, Marcusson E, et al: Antisense inhibition of survivin expression as a cancer therapeutic. Mol Cancer Ther. 10:221–232. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Rouse J, Cohen P, Trigon S, et al: A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell. 78:1027–1037. 1994. View Article : Google Scholar : PubMed/NCBI

23 

Han J, Lee JD, Bibbs L, et al: A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science. 265:808–811. 1994. View Article : Google Scholar : PubMed/NCBI

24 

Lee JC, Laydon JT, McDonnell PC, et al: A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature. 372:739–746. 1994. View Article : Google Scholar : PubMed/NCBI

25 

Freshney NW, Rawlinson L, Guesdon F, et al: Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell. 78:1039–1049. 1994. View Article : Google Scholar : PubMed/NCBI

26 

Raingeaud J, Gupta S, Rogers JS, et al: Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem. 270:7420–7426. 1995. View Article : Google Scholar

27 

Hsiao PW, Chang CC, Liu HF, et al: Activation of p38 mitogen-activated protein kinase by celecoxib oppositely regulates survivin and gamma-H2AX in human colorectal cancer cells. Toxicol Appl Pharmacol. 222:97–104. 2007. View Article : Google Scholar

28 

Hsu YF, Sheu JR, Lin CH, et al: Trichostatin A and sirtinol suppressed survivin expression through AMPK and p38 MAPK in HT29 colon cancer cells. Biochem Biophys Acta. 1820:104–115. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Toker A and Yoeli-Lerner M: Akt signaling and cancer: surviving but not moving on. Cancer Res. 66:3963–3966. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Altomare DA and Testa JR: Perturbations of the AKT signaling pathway in human cancer. Oncogene. 24:7455–7464. 2005. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Murata S, Shiragami R, Kosugi C, Tezuka T, Yamazaki M, Hirano A, Yoshimura Y, Suzuki M, Shuto K, Ohkohchi N, Ohkohchi N, et al: Antitumor effect of 1, 8-cineole against colon cancer. Oncol Rep 30: 2647-2652, 2013.
APA
Murata, S., Shiragami, R., Kosugi, C., Tezuka, T., Yamazaki, M., Hirano, A. ... Koda, K. (2013). Antitumor effect of 1, 8-cineole against colon cancer. Oncology Reports, 30, 2647-2652. https://doi.org/10.3892/or.2013.2763
MLA
Murata, S., Shiragami, R., Kosugi, C., Tezuka, T., Yamazaki, M., Hirano, A., Yoshimura, Y., Suzuki, M., Shuto, K., Ohkohchi, N., Koda, K."Antitumor effect of 1, 8-cineole against colon cancer". Oncology Reports 30.6 (2013): 2647-2652.
Chicago
Murata, S., Shiragami, R., Kosugi, C., Tezuka, T., Yamazaki, M., Hirano, A., Yoshimura, Y., Suzuki, M., Shuto, K., Ohkohchi, N., Koda, K."Antitumor effect of 1, 8-cineole against colon cancer". Oncology Reports 30, no. 6 (2013): 2647-2652. https://doi.org/10.3892/or.2013.2763
Copy and paste a formatted citation
x
Spandidos Publications style
Murata S, Shiragami R, Kosugi C, Tezuka T, Yamazaki M, Hirano A, Yoshimura Y, Suzuki M, Shuto K, Ohkohchi N, Ohkohchi N, et al: Antitumor effect of 1, 8-cineole against colon cancer. Oncol Rep 30: 2647-2652, 2013.
APA
Murata, S., Shiragami, R., Kosugi, C., Tezuka, T., Yamazaki, M., Hirano, A. ... Koda, K. (2013). Antitumor effect of 1, 8-cineole against colon cancer. Oncology Reports, 30, 2647-2652. https://doi.org/10.3892/or.2013.2763
MLA
Murata, S., Shiragami, R., Kosugi, C., Tezuka, T., Yamazaki, M., Hirano, A., Yoshimura, Y., Suzuki, M., Shuto, K., Ohkohchi, N., Koda, K."Antitumor effect of 1, 8-cineole against colon cancer". Oncology Reports 30.6 (2013): 2647-2652.
Chicago
Murata, S., Shiragami, R., Kosugi, C., Tezuka, T., Yamazaki, M., Hirano, A., Yoshimura, Y., Suzuki, M., Shuto, K., Ohkohchi, N., Koda, K."Antitumor effect of 1, 8-cineole against colon cancer". Oncology Reports 30, no. 6 (2013): 2647-2652. https://doi.org/10.3892/or.2013.2763
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