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Article

Sarcoglycans and integrins in bisphosphonate treatment: Immunohistochemical and scanning electron microscopy study

  • Authors:
    • Francesco Saverio De Ponte
    • Angelo Favaloro
    • Enrico Nastro Siniscalchi
    • Antonio Centofanti
    • Michele Runci
    • Giuseppina Cutroneo
    • Luciano Catalfamo
  • View Affiliations / Copyright

    Affiliations: Department of Experimental Medical, Surgical and Odontostomatological Sciences, University of Messina, Messina, Italy, Department of Biomedical Sciences and Morpho-functional Imaging, University of Messina, Messina, Italy
  • Pages: 2639-2646
    |
    Published online on: October 1, 2013
       https://doi.org/10.3892/or.2013.2766
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Abstract

Osteonecrosis of the jaw is an adverse outcome associated with bisphosphonate treatment. Bisphosphonates are used in conjunction with antineoplastic chemotherapy for the treatment of hypercalcaemia associated with malignancy, lytic bone metastasis and multiple myeloma. However, it is not known if the osteonecrosis of the jaw lesion originates in the bone or whether it initiates in the gingival epithelium. Two bisphosphonates are commonly used in cancer treatment. One of these is pamidronate disodium, a second-generation bisphosphonate that differs from the first-generation drug because it inhibits bone resorption at a dose that does not affect bone mineralization. The other widely used BP, zoledronate, is a third-generation drug that is the most potent bisphosphonate in clinical use, showing strong anti-osteoclastic activity, similar to pamidronate. The aim of the present study was to evaluate the modifications of human oral mucosa and underlying bone in patients after treatment with these nitrogen-containing bisphosphonates for 24 and 36 months. We analyzed the structural damage of the oral mucosa and damage of the perilesional mandibular bone observing possible correlations from them. Our results allow to express two hypotheses about the mechanism responsible for these results relating to mandible matrix necrosis; first, an increased skeletal microdamage associated with turnover suppression occurred early in treatment and progress with longer treatment duration, second, opening damage in osteonecrosis of the jaw modifies structural morphology of gingival epithelium.
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Copy and paste a formatted citation
Spandidos Publications style
De Ponte FS, Favaloro A, Siniscalchi EN, Centofanti A, Runci M, Cutroneo G and Catalfamo L: Sarcoglycans and integrins in bisphosphonate treatment: Immunohistochemical and scanning electron microscopy study. Oncol Rep 30: 2639-2646, 2013.
APA
De Ponte, F.S., Favaloro, A., Siniscalchi, E.N., Centofanti, A., Runci, M., Cutroneo, G., & Catalfamo, L. (2013). Sarcoglycans and integrins in bisphosphonate treatment: Immunohistochemical and scanning electron microscopy study. Oncology Reports, 30, 2639-2646. https://doi.org/10.3892/or.2013.2766
MLA
De Ponte, F. S., Favaloro, A., Siniscalchi, E. N., Centofanti, A., Runci, M., Cutroneo, G., Catalfamo, L."Sarcoglycans and integrins in bisphosphonate treatment: Immunohistochemical and scanning electron microscopy study". Oncology Reports 30.6 (2013): 2639-2646.
Chicago
De Ponte, F. S., Favaloro, A., Siniscalchi, E. N., Centofanti, A., Runci, M., Cutroneo, G., Catalfamo, L."Sarcoglycans and integrins in bisphosphonate treatment: Immunohistochemical and scanning electron microscopy study". Oncology Reports 30, no. 6 (2013): 2639-2646. https://doi.org/10.3892/or.2013.2766
Copy and paste a formatted citation
x
Spandidos Publications style
De Ponte FS, Favaloro A, Siniscalchi EN, Centofanti A, Runci M, Cutroneo G and Catalfamo L: Sarcoglycans and integrins in bisphosphonate treatment: Immunohistochemical and scanning electron microscopy study. Oncol Rep 30: 2639-2646, 2013.
APA
De Ponte, F.S., Favaloro, A., Siniscalchi, E.N., Centofanti, A., Runci, M., Cutroneo, G., & Catalfamo, L. (2013). Sarcoglycans and integrins in bisphosphonate treatment: Immunohistochemical and scanning electron microscopy study. Oncology Reports, 30, 2639-2646. https://doi.org/10.3892/or.2013.2766
MLA
De Ponte, F. S., Favaloro, A., Siniscalchi, E. N., Centofanti, A., Runci, M., Cutroneo, G., Catalfamo, L."Sarcoglycans and integrins in bisphosphonate treatment: Immunohistochemical and scanning electron microscopy study". Oncology Reports 30.6 (2013): 2639-2646.
Chicago
De Ponte, F. S., Favaloro, A., Siniscalchi, E. N., Centofanti, A., Runci, M., Cutroneo, G., Catalfamo, L."Sarcoglycans and integrins in bisphosphonate treatment: Immunohistochemical and scanning electron microscopy study". Oncology Reports 30, no. 6 (2013): 2639-2646. https://doi.org/10.3892/or.2013.2766
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