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Article

Expression of estrogen receptor α and β in esophageal squamous cell carcinoma

  • Authors:
    • Jing Dong
    • Shi-Wen Jiang
    • Yanru Niu
    • Ling Chen
    • Shuyan Liu
    • Tianzhong Ma
    • Xiancai Chen
    • Liyan Xu
    • Zhongjing Su
    • Haibin Chen
  • View Affiliations / Copyright

    Affiliations: Department of Histology and Embryology, Shantou University Medical College, Shantou, Guangdong, P.R. China, Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou, Guangdong, P.R. China, Institute of Oncologic Pathology, Shantou University Medical College, Shantou, Guangdong, P.R. China
  • Pages: 2771-2776
    |
    Published online on: October 1, 2013
       https://doi.org/10.3892/or.2013.2770
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Abstract

Estrogen receptors (ERs) are frequently expressed in human tumor tissues. There have been several studies concerning ER expression in esophageal cancers, yet the results are inconsistent, and the prognostic value of the receptors remains unclear. In the present study, we investigated the expression of ER protein and its correlation with clinical features of esophageal squamous cell carcinoma (ESCC) patients. Immunohistochemical staining for the ERs was carried out on paraffin-embedded primary tumor tissue sections from 89 patients with ESCC. Quantitative analyses were performed to determine the prognostic value of the expression of ERs, and Pearson's correlation was used to examine the relationship between ERα and ERβ expression levels. Our results showed that ERα immunoreactivity was significantly lower in ESCC than that in the non-neoplastic epithelium (P=0.0445), whereas the ERβ status was much stronger in ESCC than that in the non-neoplastic epithelium (P=0.0243). A significant inverse correlation was observed between ERα expression and depth of tumor invasion (P=0.0426). Correlation analysis revealed a statistically significant inverse correlation between the expression of ERα and ERβ in ESCC (r=-0.2902, P=0.0058). Kaplan-Meier survival analysis showed that the patients with ERα expression (21/89) had a better outcome than patients without ERα expression (P=0.0280), whereas patients with high ERβ immunoreactivity (44/89) were significantly associated with worse survival (P=0.0366). In conclusion, ERα and ERβ levels were inversely correlated, and the downregulation of ERα and upregulation of ERβ may indicate unfavorable prognosis of ESCC.
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1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar

2 

Sugimachi K, Matsuoka H, Matsufuji H, Maekawa S, Kai H and Okudaira Y: Survival rates of women with carcinoma of the esophagus exceed those of men. Surg Gynecol Obstet. 164:541–544. 1987.PubMed/NCBI

3 

Matsuoka H, Sugimachi K, Ueo H, Kuwano H, Nakano S and Nakayama M: Sex hormone response of a newly established squamous cell line derived from clinical esophageal carcinoma. Cancer Res. 47:4134–4140. 1987.PubMed/NCBI

4 

Ueo H, Matsuoka H, Sugimachi K, Kuwano H, Mori M and Akiyoshi T: Inhibitory effects of estrogen on the growth of a human esophageal carcinoma cell line. Cancer Res. 50:7212–7215. 1990.PubMed/NCBI

5 

Derakhshan MH, Liptrot S, Paul J, Brown IL, Morrison D and McColl KE: Oesophageal and gastric intestinal-type adenocarcinomas show the same male predominance due to a 17 year delayed development in females. Gut. 58:16–23. 2009.PubMed/NCBI

6 

Niikawa H, Suzuki T, Miki Y, et al: Intratumoral estrogens and estrogen receptors in human non-small cell lung carcinoma. Clin Cancer Res. 14:4417–4426. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Mauro LV, Dalurzo M, Carlini MJ, et al: Estrogen receptor β and epidermal growth factor receptor as early-stage prognostic biomarkers of non-small cell lung cancer. Oncol Rep. 24:1331–1338. 2010.

8 

Teng J, Wang ZY, Jarrard DF and Bjorling DE: Roles of estrogen receptor alpha and beta in modulating urothelial cell proliferation. Endocr Relat Cancer. 15:351–364. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Rath-Wolfson L, Purim O, Ram E, Morgenstern S, Koren R and Brenner B: Expression of estrogen receptor β1 in colorectal cancer: Correlation with clinicopathological variables. Oncol Rep. 27:2017–2022. 2012.

10 

Hogan AM, Collins D, Baird AW and Winter DC: Estrogen and gastrointestinal malignancy. Mol Cell Endocrinol. 307:19–24. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Woo IS, Park MJ, Choi SW, et al: Loss of estrogen receptor-α expression is associated with hypermethylation near its ATG start codon in gastric cancer cell lines. Oncol Rep. 11:617–622. 2004.

12 

Peng B, Lu B, Leygue E and Murphy LC: Putative functional characteristics of human estrogen receptor-beta isoforms. J Mol Endocrinol. 30:13–29. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Utsumi Y, Nakamura T, Nagasue N, Kubota H and Morikawa S: Role of estrogen receptors in the growth of human esophageal carcinoma. Cancer. 64:88–93. 1989. View Article : Google Scholar : PubMed/NCBI

14 

Utsumi Y, Nakamura T, Nagasue N, Kubota H, Harada T and Morikawa S: Effect of 17 beta-estradiol on the growth of an estrogen receptor-positive human esophageal carcinoma cell line. Cancer. 67:2284–2289. 1991. View Article : Google Scholar : PubMed/NCBI

15 

Nozoe T, Oyama T, Takenoyama M, Hanagiri T, Sugio K and Yasumoto K: Significance of immunohistochemical expression of estrogen receptors alpha and beta in squamous cell carcinoma of the esophagus. Clin Cancer Res. 13:4046–4050. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Kalayarasan R, Ananthakrishnan N, Kate V and Basu D: Estrogen and progesterone receptors in esophageal carcinoma. Dis Esophagus. 21:298–303. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Wang QM, Yuan L, Qi YJ, Ma ZY and Wang LD: Estrogen analogues: promising target for prevention and treatment of esophageal squamous cell carcinoma in high risk areas. Med Sci Monit. 16:HY19–HY22. 2010.PubMed/NCBI

18 

Zuguchi M, Miki Y, Onodera Y, et al: Estrogen receptor alpha and beta in esophageal squamous cell carcinoma. Cancer Sci. 103:1348–1355. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Yang H, Sukocheva OA, Hussey DJ and Watson DI: Estrogen, male dominance and esophageal adenocarcinoma: is there a link? World J Gastroenterol. 18:393–400. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Wang QM, Qi YJ, Jiang Q, Ma YF and Wang LD: Relevance of serum estradiol and estrogen receptor beta expression from a high-incidence area for esophageal squamous cell carcinoma in China. Med Oncol. 28:188–193. 2011. View Article : Google Scholar : PubMed/NCBI

21 

McDonnell DP and Norris JD: Connections and regulation of the human estrogen receptor. Science. 296:1642–1644. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Kawai H, Ishii A, Washiya K, et al: Estrogen receptor alpha and beta are prognostic factors in non-small cell lung cancer. Clin Cancer Res. 11:5084–5089. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Liu S, Zhu N and Chen H: Expression patterns of human DAB2IP protein in fetal tissues. Biotech Histochem. 87:350–359. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Bredfeldt TG, Greathouse KL, Safe SH, Hung MC, Bedford MT and Walker CL: Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT. Mol Endocrinol. 24:993–1006. 2010. View Article : Google Scholar : PubMed/NCBI

25 

He LR, Liu MZ, Li BK, et al: Prognostic impact of H3K27me3 expression on locoregional progression after chemoradiotherapy in esophageal squamous cell carcinoma. BMC Cancer. 9:4612009. View Article : Google Scholar : PubMed/NCBI

26 

He LR, Liu MZ, Li BK, et al: High expression of EZH2 is associated with tumor aggressiveness and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapy. Int J Cancer. 127:138–147. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Zhao G, Nie Y, Lv M, et al: ERbeta-mediated estradiol enhances epithelial mesenchymal transition of lung adenocarcinoma through increasing transcription of midkine. Mol Endocrinol. 26:1304–1315. 2012. View Article : Google Scholar

28 

Zhao G, Zhao S, Wang T, Zhang S, Lu K, Yu L and Hou Y: Estrogen receptor beta signaling regulates the progression of Chinese non-small cell lung cancer. J Steroid Biochem Mol Biol. 124:47–57. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Dong J, Jiang S, Niu Y, Chen L, Liu S, Ma T, Chen X, Xu L, Su Z, Chen H, Chen H, et al: Expression of estrogen receptor α and β in esophageal squamous cell carcinoma. Oncol Rep 30: 2771-2776, 2013.
APA
Dong, J., Jiang, S., Niu, Y., Chen, L., Liu, S., Ma, T. ... Chen, H. (2013). Expression of estrogen receptor α and β in esophageal squamous cell carcinoma. Oncology Reports, 30, 2771-2776. https://doi.org/10.3892/or.2013.2770
MLA
Dong, J., Jiang, S., Niu, Y., Chen, L., Liu, S., Ma, T., Chen, X., Xu, L., Su, Z., Chen, H."Expression of estrogen receptor α and β in esophageal squamous cell carcinoma". Oncology Reports 30.6 (2013): 2771-2776.
Chicago
Dong, J., Jiang, S., Niu, Y., Chen, L., Liu, S., Ma, T., Chen, X., Xu, L., Su, Z., Chen, H."Expression of estrogen receptor α and β in esophageal squamous cell carcinoma". Oncology Reports 30, no. 6 (2013): 2771-2776. https://doi.org/10.3892/or.2013.2770
Copy and paste a formatted citation
x
Spandidos Publications style
Dong J, Jiang S, Niu Y, Chen L, Liu S, Ma T, Chen X, Xu L, Su Z, Chen H, Chen H, et al: Expression of estrogen receptor α and β in esophageal squamous cell carcinoma. Oncol Rep 30: 2771-2776, 2013.
APA
Dong, J., Jiang, S., Niu, Y., Chen, L., Liu, S., Ma, T. ... Chen, H. (2013). Expression of estrogen receptor α and β in esophageal squamous cell carcinoma. Oncology Reports, 30, 2771-2776. https://doi.org/10.3892/or.2013.2770
MLA
Dong, J., Jiang, S., Niu, Y., Chen, L., Liu, S., Ma, T., Chen, X., Xu, L., Su, Z., Chen, H."Expression of estrogen receptor α and β in esophageal squamous cell carcinoma". Oncology Reports 30.6 (2013): 2771-2776.
Chicago
Dong, J., Jiang, S., Niu, Y., Chen, L., Liu, S., Ma, T., Chen, X., Xu, L., Su, Z., Chen, H."Expression of estrogen receptor α and β in esophageal squamous cell carcinoma". Oncology Reports 30, no. 6 (2013): 2771-2776. https://doi.org/10.3892/or.2013.2770
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