Prognostic implications of node metastatic features in OSCC: a retrospective study on 121 neck dissections

  • Authors:
    • Maria Contaldo
    • Antonio Di Napoli
    • Giuseppe Pannone
    • Renato Franco
    • Franco Ionna
    • Antonia Feola
    • Alfredo De Rosa
    • Angela Santoro
    • Carolina Sbordone
    • Francesco Longo
    • Daniela Pasquali
    • Carla Loreto
    • Filippo Ricciardiello
    • Gennaro Esposito
    • Luigi D'Angelo
    • Angelo Itro
    • Pantaleo Bufo
    • Vincenzo Tombolini
    • Rosario Serpico
    • Marina Di Domenico
  • View Affiliations

  • Published online on: October 2, 2013     https://doi.org/10.3892/or.2013.2779
  • Pages: 2697-2704
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Abstract

Lymph node metastases are responsible for shorter survival in oral squamous cell carcinoma (OSCC). The aim of the present study was to assess the node metastasis frequency and survival according to the node metastasis features in 121 neck dissections (NDs) performed for OSCC, identifying evidence-based correlations and contrasts with previous literature. The retrospective study involved 121 patients affected by OSCC who had undergone modified radical ND (MRND) for therapeutic, elective reasons or after intraoperative positivity to metastasis of sentinel lymph nodes (SLN+). Node metastasis frequency and behaviour (typical vs. atypical) and their number and distribution according to pre-surgical cTNM cancer staging were considered and overall survival Kaplan-Meier curves were calculated for each group in order to compare mortality according to ND type (elective, therapeutic, after SLN+), lymph node metastatic pattern (typical or atypical), size (micrometastasis vs. macrometastasis) and number. Results showed statistically significant different overall survival according to pre-surgical staging, number of lymph nodes harvested and intent to surgery. Sentinel lymph node resulted in the sole positive node affected by metastasis in small cT1- cT2/cN0 OSCC and an ND subsequent to its positivity during intraoperative assessment may be considered an overtreatment.
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December 2013
Volume 30 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Contaldo M, Di Napoli A, Pannone G, Franco R, Ionna F, Feola A, De Rosa A, Santoro A, Sbordone C, Longo F, Longo F, et al: Prognostic implications of node metastatic features in OSCC: a retrospective study on 121 neck dissections. Oncol Rep 30: 2697-2704, 2013.
APA
Contaldo, M., Di Napoli, A., Pannone, G., Franco, R., Ionna, F., Feola, A. ... Di Domenico, M. (2013). Prognostic implications of node metastatic features in OSCC: a retrospective study on 121 neck dissections. Oncology Reports, 30, 2697-2704. https://doi.org/10.3892/or.2013.2779
MLA
Contaldo, M., Di Napoli, A., Pannone, G., Franco, R., Ionna, F., Feola, A., De Rosa, A., Santoro, A., Sbordone, C., Longo, F., Pasquali, D., Loreto, C., Ricciardiello, F., Esposito, G., D'Angelo, L., Itro, A., Bufo, P., Tombolini, V., Serpico, R., Di Domenico, M."Prognostic implications of node metastatic features in OSCC: a retrospective study on 121 neck dissections". Oncology Reports 30.6 (2013): 2697-2704.
Chicago
Contaldo, M., Di Napoli, A., Pannone, G., Franco, R., Ionna, F., Feola, A., De Rosa, A., Santoro, A., Sbordone, C., Longo, F., Pasquali, D., Loreto, C., Ricciardiello, F., Esposito, G., D'Angelo, L., Itro, A., Bufo, P., Tombolini, V., Serpico, R., Di Domenico, M."Prognostic implications of node metastatic features in OSCC: a retrospective study on 121 neck dissections". Oncology Reports 30, no. 6 (2013): 2697-2704. https://doi.org/10.3892/or.2013.2779