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2014-January Volume 31 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

microRNA-27a functions as a tumor suppressor in esophageal squamous cell carcinoma by targeting KRAS

  • Authors:
    • Linan Zhu
    • Zhiju Wang
    • Qingxia Fan
    • Ruilin Wang
    • Yan Sun
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China, Department of Basic Medicine, Zhengzhou University, Zhengzhou, Henan, P.R. China
  • Pages: 280-286
    |
    Published online on: October 23, 2013
       https://doi.org/10.3892/or.2013.2807
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Abstract

microRNAs (miRNAs) have been suggested to play a vital role in regulating tumor progression and invasion. However, the expression of miR-27a in esophageal squamous cell carcinoma (ESCC) and its effect on the tumorigenesis of ESCC are unclear. In the present study, we found that miR-27a was downregulated in esophageal carcinoma cell lines and ESCC specimens with lymph node metastasis. Furthermore, we demonstrated that miR-27a binds to the 3'-untranslated region (UTR) of KRAS and inhibits the expression of the KRAS protein. miR-27a levels were inversely correlated with levels of KRAS mRNA and protein in ESCC specimens. Both in vitro and in vivo assays revealed that miR-27a attenuated ESCC proliferation, invasion and tumor growth in nude mice. miR-27a exerts its tumor suppressor function through inhibition of the KRAS-related ERK pathways. Our findings suggest, for the first time, that miR-27a suppresses tumorigenesis of ESCC by targeting KRAS.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu L, Wang Z, Fan Q, Wang R and Sun Y: microRNA-27a functions as a tumor suppressor in esophageal squamous cell carcinoma by targeting KRAS. Oncol Rep 31: 280-286, 2014.
APA
Zhu, L., Wang, Z., Fan, Q., Wang, R., & Sun, Y. (2014). microRNA-27a functions as a tumor suppressor in esophageal squamous cell carcinoma by targeting KRAS. Oncology Reports, 31, 280-286. https://doi.org/10.3892/or.2013.2807
MLA
Zhu, L., Wang, Z., Fan, Q., Wang, R., Sun, Y."microRNA-27a functions as a tumor suppressor in esophageal squamous cell carcinoma by targeting KRAS". Oncology Reports 31.1 (2014): 280-286.
Chicago
Zhu, L., Wang, Z., Fan, Q., Wang, R., Sun, Y."microRNA-27a functions as a tumor suppressor in esophageal squamous cell carcinoma by targeting KRAS". Oncology Reports 31, no. 1 (2014): 280-286. https://doi.org/10.3892/or.2013.2807
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu L, Wang Z, Fan Q, Wang R and Sun Y: microRNA-27a functions as a tumor suppressor in esophageal squamous cell carcinoma by targeting KRAS. Oncol Rep 31: 280-286, 2014.
APA
Zhu, L., Wang, Z., Fan, Q., Wang, R., & Sun, Y. (2014). microRNA-27a functions as a tumor suppressor in esophageal squamous cell carcinoma by targeting KRAS. Oncology Reports, 31, 280-286. https://doi.org/10.3892/or.2013.2807
MLA
Zhu, L., Wang, Z., Fan, Q., Wang, R., Sun, Y."microRNA-27a functions as a tumor suppressor in esophageal squamous cell carcinoma by targeting KRAS". Oncology Reports 31.1 (2014): 280-286.
Chicago
Zhu, L., Wang, Z., Fan, Q., Wang, R., Sun, Y."microRNA-27a functions as a tumor suppressor in esophageal squamous cell carcinoma by targeting KRAS". Oncology Reports 31, no. 1 (2014): 280-286. https://doi.org/10.3892/or.2013.2807
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