microRNA-27a functions as a tumor suppressor in esophageal squamous cell carcinoma by targeting KRAS

  • Authors:
    • Linan Zhu
    • Zhiju Wang
    • Qingxia Fan
    • Ruilin Wang
    • Yan Sun
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  • Published online on: October 23, 2013     https://doi.org/10.3892/or.2013.2807
  • Pages: 280-286
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Abstract

microRNAs (miRNAs) have been suggested to play a vital role in regulating tumor progression and invasion. However, the expression of miR-27a in esophageal squamous cell carcinoma (ESCC) and its effect on the tumorigenesis of ESCC are unclear. In the present study, we found that miR-27a was downregulated in esophageal carcinoma cell lines and ESCC specimens with lymph node metastasis. Furthermore, we demonstrated that miR-27a binds to the 3'-untranslated region (UTR) of KRAS and inhibits the expression of the KRAS protein. miR-27a levels were inversely correlated with levels of KRAS mRNA and protein in ESCC specimens. Both in vitro and in vivo assays revealed that miR-27a attenuated ESCC proliferation, invasion and tumor growth in nude mice. miR-27a exerts its tumor suppressor function through inhibition of the KRAS-related ERK pathways. Our findings suggest, for the first time, that miR-27a suppresses tumorigenesis of ESCC by targeting KRAS.
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2014-January
Volume 31 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zhu L, Wang Z, Fan Q, Wang R and Sun Y: microRNA-27a functions as a tumor suppressor in esophageal squamous cell carcinoma by targeting KRAS. Oncol Rep 31: 280-286, 2014
APA
Zhu, L., Wang, Z., Fan, Q., Wang, R., & Sun, Y. (2014). microRNA-27a functions as a tumor suppressor in esophageal squamous cell carcinoma by targeting KRAS. Oncology Reports, 31, 280-286. https://doi.org/10.3892/or.2013.2807
MLA
Zhu, L., Wang, Z., Fan, Q., Wang, R., Sun, Y."microRNA-27a functions as a tumor suppressor in esophageal squamous cell carcinoma by targeting KRAS". Oncology Reports 31.1 (2014): 280-286.
Chicago
Zhu, L., Wang, Z., Fan, Q., Wang, R., Sun, Y."microRNA-27a functions as a tumor suppressor in esophageal squamous cell carcinoma by targeting KRAS". Oncology Reports 31, no. 1 (2014): 280-286. https://doi.org/10.3892/or.2013.2807